Antimicrobial residues in animal waste and water resources proximal to large-scale swine and poultry feeding operations

Campagnolo, Enzo R.; Johnson, Kammy R.; Karpati, Adam; Rubin, Carol; Kolpin, Dana W.; Meyer, Michael T.; Esteban, J.Emilio; Currier, Russell W.; Smith, Kathleen A.; Thu, Kendall; McGeehin, Michael A.

doi:10.1016/s0048-9697(02)00233-4

Cited by 454 publications

(267 citation statements)

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“…Additionally, Chen et al (2007) identified genes conferring erythromycin (erm) and tetracycline (tet) resistance persisting in swine manure post biofilter treatment. Prior studies have identified elevated levels of antibiotics, antibioticresistant bacteria and antibiotic resistance genes in ground and surface water surrounding confined animal feeding operations (Campagnolo et al, 2002;Chee-Sanford et al, 2009;Heuer et al, 2011). The potential for antibiotics, antibiotic-resistant bacteria and antibiotic-resistance genes leaching into the environment is becoming of greater concern, with approximately 9.2 million hectares of farmland receiving manure annually (Dolliver and Gupta, 2007).…”

Section: Introductionmentioning

confidence: 99%

Fate and transport of tylosin-resistant bacteria and macrolide resistance genes in artificially drained agricultural fields receiving swine manure

Luby

Moorman

Soupir

2016

Science of The Total Environment

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Application of manure from swine treated with antibiotics introduces antibiotics and antibiotic resistance genes to soil with the potential for further movement in drainage water, which may contribute to the increase in antibiotic resistance in non-agricultural settings. We compared losses of antibiotic-resistant Enterococcus and macrolide-resistance (erm and msrA) genes in water draining from plots with or without swine manure application under chisel plow and no till conditions. Concentrations of ermB,ermC and ermF were all > 10 9 copies g − 1 in manure from tylosin-treated swine, and application of this manure resulted in short-term increases in the abundance of these genes in soil. Abundances of ermB, ermC and ermF in manured soil returned to levels identified in non-manured control plots by the spring following manure application. Tillage practices yielded no significant differences (p > 0.10) in enterococci or erm gene concentrations in drainage water and were therefore combined for further analysis. While enterococci and tylosin-resistant enterococci concentrations in drainage water showed no effects of manure application, ermB and ermF concentrations in drainage water from manured plots were significantly higher (p < 0.01) than concentrations coming from non-manured plots. ErmB and ermF were detected in 78% and 44%, respectively, of water samples draining from plots receiving manure. Although ermC had the highest concentrations of the three genes in drainage water, there was no effect of manure application on ermC abundance. MsrA was not detected in manure, soil or water. This study is the first to report significant increases in abundance of resistance genes in waters draining from agricultural land due to manure application. H I G H L I G H T S• Higher levels of ermB and ermF in drainage are attributable to manure.• Fall manure application resulted in transient increases in soil enterococci.• Manure application did not affect enterococci levels in drainage water. Application of manure from swine treated with antibiotics introduces antibiotics and antibiotic resistance genes to soil with the potential for further movement in drainage water, which may contribute to the increase in antibiotic resistance in non-agricultural settings. We compared losses of antibiotic-resistant Enterococcus and macrolide-resistance (erm and msrA) genes in water draining from plots with or without swine manure application under chisel plow and no till conditions. Concentrations of ermB, ermC and ermF were all N10 9 copies g −1 in manure from tylosin-treated swine, and application of this manure resulted in short-term increases in the abundance of these genes in soil. Abundances of ermB, ermC and ermF in manured soil returned to levels identified in non-manured control plots by the spring following manure application. Tillage practices yielded no significant differences (p N 0.10) in enterococci or erm gene concentrations in drainage water and were therefore combined for further analysis. While enterococci and tylosin...

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Section: Introductionmentioning

confidence: 99%

Fate and transport of tylosin-resistant bacteria and macrolide resistance genes in artificially drained agricultural fields receiving swine manure

Luby

Moorman

Soupir

2016

Science of The Total Environment

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“…High concentrations of antibiotics have been frequently found in animal manure, such as in pig manure (Chen et al, 2012a;Jacobsen and Halling-Sorensen, 2006;Martínez-Carballo et al, 2007;Zhao et al, 2010), cattle manure (Zhao et al, 2010) and chicken manures (Karci and Balcioglu, 2009;Martínez-Carballo et al, 2007;Zhao et al, 2010) at concentrations up to hundreds of mg/kg, and in animal wastewater at concentrations up to μg/L (Ben et al, 2008;Campagnolo et al, 2002;Chen et al, 2012b;Tagiri-Endo et al, 2009;Watanabe et al, 2010). In Chinese livestock farms, most of wastewater and manure are directly or indirectly discharged into surface water or applied onto agricultural land, resulting in the contamination of antibiotics in aquatic and terrestrial environments.…”

Section: Introductionmentioning

confidence: 99%

“…Antibiotics associated with livestock manure and wastewater application onto land can also enter surface water via run off, or leach into groundwater (Davis et al, 2006;Dolliver and Gupta, 2008). So far, antibiotic residues have been reported in the surrounding environments of animal farms, with the concentrations from not detected to 2683 μg/kg in soil (Hu et al, 2010;Li et al, 2011), from 2 ng/L to 6800 ng/L in surface water (Christian et al, 2003;Matsui et al, 2008), and from 1.4 to 1400 ng/L in groundwater (Batt et al, 2006;Campagnolo et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

“…However, most reported investigations focused more on tetracyclines, sulfonamides and fluoroquinolones in animal wastes in livestock farms due to available analytical methods, less on other classes of antibiotics such as bacitracin, leucomycin, lincomycin, florfenicol, ceftiofur and ionophores (Ben et al, 2008;Campagnolo et al, 2002;Chen et al, 2012aChen et al, , 2012bJacobsen and Halling-Sorensen, 2006;Karci and Balcioglu, 2009;Martínez-Carballo et al, 2007;Tagiri-Endo et al, 2009;Watanabe et al, 2010;Zhao et al, 2010). Therefore, it is necessary to screen various classes of antibiotics in the animal wastes of livestock farms and their receiving environments to comprehensively evaluate the risks posed by the antibiotics used in livestock farms.…”

Section: Introductionmentioning

confidence: 99%

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Excretion masses and environmental occurrence of antibiotics in typical swine and dairy cattle farms in China

Zhou

Ying

Liu

et al. 2013

Science of The Total Environment

362

131

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“…In an US investigation, 31% of the water samples proximal to swine farms and 67% of the samples proximal to poultry farms were found to contain antimicrobial compounds used in these farms: chlor-, oxy-and tetracycline, sarafloxacin, lincomycin and sulfadimethoxine, generally at levels < 4 g l −1 (Campagnolo et al, 2002). In the UK field study, mass losses from soil into drainage water accounted for not more than 0.5% of the dose applied to the soil.…”

Section: Functional Validation For Surface Watermentioning

confidence: 99%

Validation of the exposure assessment for veterinary medicinal products

Montforts

2006

Science of The Total Environment

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Under the EU Directive 2004/28/EC, an environmental risk assessment of new veterinary medicinal products is required. Given the nature of risk assessment for new applications, there is a need to model exposure concentrations. Critical evaluations are essential to ensure that the use of models by regulators does not result in the propagation of misleading information. The empirical validations of soil exposure models, previously discussed in this journal, indicate that it is impossible to analyse the contribution of every model parameter to the variability in the predictions. In particular, the prediction of the slurry concentration is challenged by uncertainties concerning dilution, mixing and dissipation of residues. Surface water and groundwater models generated highly deviating results compared to the field results, questioning the usefulness of the available screening models. Animal husbandry, slurry handling and environmental conditions throughout Europe are considered in order to define realistic worst case scenarios, to be used in conjunction with distribution models for the environmental risk assessment of veterinary medicinal products at registration. Given the variability in manure management practice throughout Europe, a deterministic approach for the manure-to-soil model was selected. Both worst case and best case scenario were developed. Several modelling assumptions applied in the surface water exposure model for fish nursery effluent were validated against newly available data. Since the available data give no proof that a settling tank contributes to the removal of pesticides from waste water, it is recommended for risk assessment purposes to consider the contribution of the settling tank to removal of pesticides and medicines to be negligible. Surface water dilution factors may be considered to be rather small, a factor of 2, for low flow situations.

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Antimicrobial residues in animal waste and water resources proximal to large-scale swine and poultry feeding operations

Cited by 454 publications

References 16 publications

Fate and transport of tylosin-resistant bacteria and macrolide resistance genes in artificially drained agricultural fields receiving swine manure

Fate and transport of tylosin-resistant bacteria and macrolide resistance genes in artificially drained agricultural fields receiving swine manure

Excretion masses and environmental occurrence of antibiotics in typical swine and dairy cattle farms in China

Validation of the exposure assessment for veterinary medicinal products

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