ANTIMICROBIAL PEPTIDES IN SEMEN EXTENDERS: A VALUABLE REPLACEMENT OPTION FOR ANTIBIOTICS IN CRYOPRESERVATION- A Prospective Review

As, Vickram; Dhama, Kuldeep; Archana, K; Parameswari, R; M, Ramesh Pathy; Iqbal, Hafiz M.N.; Sridharan, T. B.

doi:10.18006/2017.5(4).578.588

Cited by 2 publications

(3 citation statements)

References 76 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A biomimetic substance, Ceragyn, is reported to be active against most of the important organisms implicated in equine endometritis, namely both free-floating and biofilms of S. equi ssp zooepidemicus, E coli, and K. pneumoniae, although apparently the activity against Pseudomonas was less convincing (57). There is a suggestion that bacteria do not become resistant to these substances although this speculation remains to be substantiated (58).…”

Section: Antimicrobial Peptidesmentioning

confidence: 99%

“…Peptides are released by neutrophils and exert an antibacterial effect (58). A biomimetic substance, Ceragyn, is reported to be active against most of the important organisms implicated in equine endometritis, namely both free-floating and biofilms of S. equi ssp zooepidemicus, E coli, and K. pneumoniae, although apparently the activity against Pseudomonas was less convincing (57).…”

Section: Antimicrobial Peptidesmentioning

confidence: 99%

See 1 more Smart Citation

A Novel Approach to Minimising Acute Equine Endometritis That May Help to Prevent the Development of the Chronic State

Morrell

Rocha

2022

Front. Vet. Sci.

View full text Add to dashboard Cite

One of the most commonly encountered challenges in equine breeding is endometritis, which can be difficult to resolve and causes considerable economic losses to the industry. It is a multifactorial condition, developing as an exaggerated form of the normal physiological response to breeding. Seminal plasma proteins, spermatozoa, bacteria and debris initiate an inflammatory response; the resulting fluid and neutrophils are then cleared from the uterus along with the debris. However, in some mares, the response is prolonged or exaggerated, with much fluid formation and neutrophil infiltration leading to acute endometritis. A bacterial cause has been implicated, although in some cases no pathogenic organisms can be isolated on culture. It has been postulated that any one of a variety of bacteria could be involved, or dysbiosis of the uterine microbiome could be responsible. Repeated episodes of acute endometritis may lead to the pathology associated with chronic endometritis, with mucociliary dysfunction, vascular degeneration and plasma cell infiltration. This review examines the information that is currently available about equine endometritis, particularly about the role of the inseminate in the uterus, and its current treatment. There are some promising lines of research into treatment or prevention that may help to resolve the issue.

show abstract

Section: Antimicrobial Peptidesmentioning

confidence: 99%

Section: Antimicrobial Peptidesmentioning

confidence: 99%

A Novel Approach to Minimising Acute Equine Endometritis That May Help to Prevent the Development of the Chronic State

Morrell

Rocha

2022

Front. Vet. Sci.

View full text Add to dashboard Cite

show abstract

“…The authors considered that the antimicrobial activity of the treated samples was similar to the controls with the usual levels of antibiotics. However, since bacteria are still present and viable, there is no guarantee that the low concentration of antibiotics would not be conducive to the development of antimicrobial resistance [62].…”

Section: Plant Extractsmentioning

confidence: 99%

Alternatives to Antibiotics in Semen Extenders Used in Artificial Insemination

Morrell¹,

Malaluang²,

Cojkic³

et al. 2022

The Global Antimicrobial Resistance Epidemic - Innovative Approaches and Cutting-Edge Solutions

View full text Add to dashboard Cite

Antimicrobial resistance is a serious global threat requiring a widespread response. Both veterinarians and medical doctors should restrict antibiotic usage to therapeutic use only, after determining the sensitivity of the causal organism. However, the addition of antibiotics to semen extenders for animal artificial insemination represents a hidden, non-therapeutic use of antimicrobial substances. Artificial insemination for livestock breeding is a huge global enterprise with hundreds of million sperm doses prepared annually. However, reporting of antimicrobial resistance in semen is increasing. This review discusses the consequences of bacteria in semen samples, as well as the effect of antimicrobial substances in semen extenders on bacteria in the environment and even on personnel. Alternatives to antibiotics have been reported in the scientific literature and are reviewed here. The most promising of these, removal of the majority of bacteria by colloid centrifugation, is considered in detail, especially results from an artificial insemination study in pigs. In conclusion, colloid centrifugation is a practical method of physically removing bacteria from semen, which does not induce antibiotic resistance. Sperm quality in stored semen samples may be improved at the same time.

show abstract

ANTIMICROBIAL PEPTIDES IN SEMEN EXTENDERS: A VALUABLE REPLACEMENT OPTION FOR ANTIBIOTICS IN CRYOPRESERVATION- A Prospective Review

Cited by 2 publications

References 76 publications

A Novel Approach to Minimising Acute Equine Endometritis That May Help to Prevent the Development of the Chronic State

A Novel Approach to Minimising Acute Equine Endometritis That May Help to Prevent the Development of the Chronic State

Alternatives to Antibiotics in Semen Extenders Used in Artificial Insemination

Contact Info

Product

Resources

About