Antimicrobial peptides-An alternative candidates to antibiotics against Staphylococcus aureus and its antibiotic-resistant strains

Mazumdar, Aninda; Adam, Vojtěch

doi:10.31083/j.jmcm.2021.01.208

Cited by 6 publications

(8 citation statements)

References 147 publications

(168 reference statements)

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“…To minimize the harmful side effects and increase antibacterial efficacy, great efforts are being made to develop artificial AMPs. 70 The development of artificial AMPs with new structures and unique properties will depend on advances in organic synthesis techniques.…”

Section: Outlooksmentioning

confidence: 99%

“…In addition to these advantageous properties, AMPs also have disadvantages, which often include cytotoxic and hemolytic effects. To minimize the harmful side effects and increase antibacterial efficacy, great efforts are being made to develop artificial AMPs 70 . The development of artificial AMPs with new structures and unique properties will depend on advances in organic synthesis techniques.…”

Section: Outlooksmentioning

confidence: 99%

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Role of membrane proteins in bacterial resistance to antimicrobial peptides

Vimberg

Buriánková

Mazumdar

et al. 2021

Medicinal Research Reviews

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Several natural antimicrobial peptides (AMPs), including the novel semisynthetic lipoglycopeptide antibiotics telavancin, dalbavancin, and oritavancin, have been approved for clinical use to address the growing problem of multiple antibioticresistant Gram-positive bacterial infections. Nevertheless, the efficacy of these antibiotics has already been compromised. The SARS-CoV-2 pandemic led to the increased clinical use of all antibiotics, further promoting the development of bacterial resistance. Therefore, it is critical to gain a deeper understanding of the role of resistance mechanisms to minimize the consequential risks of long-term antibiotic use and misuse.Here, we summarize for the first time the current knowledge of resistance mechanisms that have been shown to cause resistance to clinically used AMPs, with particular focus on membrane proteins that have been reported to interfere with the activity of AMPs by affecting the binding of AMPs to bacteria.

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Section: Outlooksmentioning

confidence: 99%

Section: Outlooksmentioning

confidence: 99%

Role of membrane proteins in bacterial resistance to antimicrobial peptides

Vimberg

Buriánková

Mazumdar

et al. 2021

Medicinal Research Reviews

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“…Mutually controlled by host immune condition, microflora organization, and antimicrobial interventions, AMR evolu-tion occurs with the multidrug resistance [7,8]. While AMR could not be pragmatically eradicated, antimicrobials will endure to miss their potency, and, in the close future, more people may die from infections [9][10][11]. Therefore, it is crucial to explore original effective and broad-spectrum antibacterial agents to control bacteria, which can be antibiotic resistant, highly virulent, and high costs for the medication.…”

Section: Introductionmentioning

confidence: 99%

In-Depth Study of Thymus vulgaris Essential Oil: Towards Understanding the Antibacterial Target Mechanism and Toxicological and Pharmacological Aspects

Akermi

Smaoui

Fourati

et al. 2022

BioMed Research International

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Questions have been raised apropos the emerging problem of microbial resistance, which may pose a great hazard to the human health. Among biosafe compounds are essential oils which captured consumer draw due to their multifunctional properties compared to chemical medication drugs. Here, we examined the chemical profile and the mechanism(s) of action of the Thymus vulgaris essential oil (TVEO) against a Gram-negative bacterium Salmonella enterica Typhimurium ATTCC 10028 (S. enterica Typhimurium ATTCC 10028) and two Gram-positive bacteria Staphyloccocus aureus ATCC 6538 (S. aureus ATCC 6538) and Listeria monocytogenes ATCC 19117 (L. monocytogenes ATCC 19117). Findings showed that TVEO was principally composed of thymol, o-cymene, and γ-terpinene with 47.44, 16.55, and 7.80%, respectively. Molecular docking simulations stipulated that thymol and β-sesquiphellandrene (a minor compound at 1.37%) could target multiple bacterial pathways including topoisomerase II and DNA and RNA polymerases of the three tested bacteria. This result pointed plausible impairments of the pathogenic bacteria cell replication and transcription processes. Through computational approach, the VEGA quantitative structure–activity relationship (QSAR) model, we revealed that among twenty-six TVEO compounds, sixteen had no toxic effects and could be safe for human consumption as compared to the Food and Drug Administration (FDA) approved drugs (ciprofloxacin and rifamycin SV). Assessed by the SwissADME server, the pharmacokinetic profile of all identified TVEO compounds define their absorption, distribution, metabolism, and excretion (ADME) properties and were assessed. In order to predict their biological activity spectrum based on their chemical structure, all TVEO compounds were subjected to PASS (Prediction of Activity Spectra for Substances) online tool. Results indicated that the tested compounds could have multiple biological activities and various enzymatic targets. Findings of our study support that identified compounds of TVEO can be a safe and effective alternative to synthetic drugs and can easily combats hazardous multidrug-resistant bacteria.

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“…At the same time, it is crucial to preserve the ability to use clinically accepted antibiotics, especially so-called “last resort” antibiotics, which are used for treating multiple drug-resistant infectious agents. The development of new therapeutics that modulate existing resistance mechanisms may increase the lifetime of already accepted antibiotics and overcome the spread of resistance [ 1 , 2 , 3 , 4 , 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…VanY, a D,D-carboxypeptidase, eliminates D-Ala-D-Ala from peptidoglycan precursors, minimizing the number of primary binding sites for glycopeptide antibiotics. VanZ is independent of the peptidoglycan modification mechanism, and decreases the sensitivity of bacteria to lipoglycopeptide antibiotics, including TEI, but not VAN [ 2 , 14 , 15 , 16 ]. The vanZ orthologs are also present in the genomes of pathogenic bacteria like Streptococcus spp.…”

Section: Introductionmentioning

confidence: 99%

Specific Inhibition of VanZ-Mediated Resistance to Lipoglycopeptide Antibiotics

Sur

Mazumdar

Vimberg

et al. 2021

IJMS

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Teicoplanin is a natural lipoglycopeptide antibiotic with a similar activity spectrum as vancomycin; however, it has with the added benefit to the patient of low cytotoxicity. Both teicoplanin and vancomycin antibiotics are actively used in medical practice in the prophylaxis and treatment of severe life-threatening infections caused by gram-positive bacteria, including methicillin-resistant Staphylococcus aureus, Enterococcus faecium and Clostridium difficile. The expression of vancomycin Z (vanZ), encoded either in the vancomycin A (vanA) glycopeptide antibiotic resistance gene cluster or in the genomes of E. faecium, as well as Streptococcus pneumoniae and C. difficile, was shown to specifically compromise the antibiotic efficiency through the inhibition of teicoplanin binding to the bacterial surface. However, the exact mechanisms of this action and protein structure remain unknown. In this study, the three-dimensional structure of VanZ from E. faecium EnGen0191 was predicted by using the I-TASSER web server. Based on the VanZ structure, a benzimidazole based ligand was predicted to bind to the VanZ by molecular docking. Importantly, this new ligand, named G3K, was further confirmed to specifically inhibit VanZ-mediated resistance to teicoplanin in vivo.

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Antimicrobial peptides-An alternative candidates to antibiotics against Staphylococcus aureus and its antibiotic-resistant strains

Cited by 6 publications

References 147 publications

Role of membrane proteins in bacterial resistance to antimicrobial peptides

Role of membrane proteins in bacterial resistance to antimicrobial peptides

In-Depth Study of Thymus vulgaris Essential Oil: Towards Understanding the Antibacterial Target Mechanism and Toxicological and Pharmacological Aspects

Specific Inhibition of VanZ-Mediated Resistance to Lipoglycopeptide Antibiotics

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