Antimicrobial hydrogels: A new weapon in the arsenal against multidrug-resistant infections

Ng, Victor Wee Lin; Chan, Julian M. W.; Sardón, Haritz; Ono, Robert J.; Garcı́a, Jeannette M.; Yang, Yi Yan; Hedrick, James L.

doi:10.1016/j.addr.2014.10.028

Cited by 243 publications

(189 citation statements)

References 137 publications

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“…Data from the World Health Organization (WHO) indicate that the diseases caused by these pathogens are one of the leading causes of global hospitalization and mortality [173]. Moreover, the appearance of multidrug-resistant bacteria is driven not only by the over-prescription of antibiotics and their inadequate use by patients [174,175], and but also from the intensive use of antibiotics in animal husbandry, agriculture and aquaculture [176,177]. Additionally, issues like systemic toxicity and the short half-life of antibiotics should not be neglected [174,175,178].…”

Section: Biocide-releasing Polymersmentioning

confidence: 99%

Recent Developments in Antimicrobial Polymers: A Review

et al. 2016

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Antimicrobial polymers represent a very promising class of therapeutics with unique characteristics for fighting microbial infections. As the classic antibiotics exhibit an increasingly low capacity to effectively act on microorganisms, new solutions must be developed. The importance of this class of materials emerged from the uncontrolled use of antibiotics, which led to the advent of multidrug-resistant microbes, being nowadays one of the most serious public health problems. This review presents a critical discussion of the latest developments involving the use of different classes of antimicrobial polymers. The synthesis pathways used to afford macromolecules with antimicrobial properties, as well as the relationship between the structure and performance of these materials are discussed.

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Section: Biocide-releasing Polymersmentioning

confidence: 99%

Recent Developments in Antimicrobial Polymers: A Review

et al. 2016

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“…The excellent hydrophilicity of hydrogels, high swelling ratio and biocompatibility, promote their usage widely in biomedical areas such as tissue engineering, drug delivery, biosensor, and so on [1,2]. Due to the superior biomedical relevance, there is an increasing interest to develop the antibacterial hydrogels [3,4].…”

Section: Introductionmentioning

confidence: 98%

Synthesis and characterization of antibacterial carboxymethyl Chitosan/ZnO nanocomposite hydrogels

Wahid

Yin

Xue

et al. 2016

International Journal of Biological Macromolecules

153

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“…Developing hydrogels that possess inherent antimicrobial activity represents a promising approach that will significantly alleviate any safety concerns associated with microbial contamination of the matrix during and post implantation. 6,18–20 …”

Section: Introductionmentioning

confidence: 99%

“…6,20–32 Amphiphilic peptides consisting of cationic and hydrophobic residues can be rationally designed to mimic the structure of natural antimicrobial peptides (AMPs) and can readily be used as the molecular building blocks for functional supramolecular hydrogels with inherent antimicrobial activity. Several groups have demonstrated the concept of de novo designed amphiphilic peptide hydrogels with broad-spectrum antimicrobial activity while having minimum cytotoxicity to eukaryotic cells.…”

Section: Introductionmentioning

confidence: 99%

Self-assembly of cationic multidomain peptide hydrogels: supramolecular nanostructure and rheological properties dictate antimicrobial activity

Jiang

Sellati

et al. 2015

Nanoscale

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Hydrogels are an important class of biomaterials that have been widely utilized for a variety of biomedical/medical applications. The biological performance of hydrogels, particularly those used as wound dressing could be greatly advanced if imbued with inherent antimicrobial activity capable of staving off colonization of the wound site by opportunistic bacterial pathogens. Possessing such antimicrobial properties would also protect the hydrogel itself from being adversely affected by microbial attachment to its surface. We have previously demonstrated the broad-spectrum antimicrobial activity of supramolecular assemblies of cationic multi-domain peptides (MDPs) in solution. Here, we extend the 1-D soluble supramolecular assembly to 3-D hydrogels to investigate the effect of the supramolecular nanostructure and its rheological properties on the antimicrobial activity of self-assembled hydrogels. Among designed MDPs, the bactericidal activity of peptide hydrogels was found to follow an opposite trend to that in solution. Improved antimicrobial activity of self-assembled peptide hydrogels is dictated by the combined effect of supramolecular surface chemistry and storage modulus of the bulk materials, rather than the ability of individual peptides/peptide assemblies to penetrate bacterial cell membrane as observed in solution. The structure–property–activity relationship developed through this study will provide important guidelines for designing biocompatible peptide hydrogels with built-in antimicrobial activity for various biomedical applications.

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Antimicrobial hydrogels: A new weapon in the arsenal against multidrug-resistant infections

Cited by 243 publications

References 137 publications

Recent Developments in Antimicrobial Polymers: A Review

Recent Developments in Antimicrobial Polymers: A Review

Synthesis and characterization of antibacterial carboxymethyl Chitosan/ZnO nanocomposite hydrogels

Self-assembly of cationic multidomain peptide hydrogels: supramolecular nanostructure and rheological properties dictate antimicrobial activity

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