Antimicrobial functionalization of silicone surfaces with engineered short peptides having broad spectrum antimicrobial and salt-resistant properties

Preventing microbial colonisation of catheters: Antimicrobial and antibiofilm activities of cellobiose dehydrogenase

“…Therefore, prevention of biofilm formation and microbial colonisation is key to a successful strategy against medical device-related infections. Over the past decades, the development of antimicrobial coatings containing substances such as antibiotics, silver, gendine, nitric oxide [9,10] and, more recently, antimicrobial peptides is being intensively explored [11]. However, most of these coatings have raised issues regarding cytotoxicity and an increase of antibiotic resistance [8].…”

Antibacterial Properties of hLf1–11 Peptide onto Titanium Surfaces: A Comparison Study Between Silanization and Surface Initiated Polymerization

“…Silanization has been successfully used to functionalize metallic biomaterials with bioactive 8,[23][24][25][26] . This method of surface modification allows the covalent attachment of peptides and proteins through the use of organofunctional alkoxysilane molecules that react with hydroxyl groups present at the surface of the material.…”

Antifungal activity of cathelicidin peptides against planktonic and biofilm cultures of Candida species isolated from vaginal infections

“…C. albicans adhesion to and biofilm formation on the obtained biomaterials was reduced to various extents depending on the peptide and the type of the linker used. Importantly, the latter study suggested that the membrane-active killing mechanism also applies to covalently immobilized peptides [44].…”

“…Reduced biofilm formation in an in vitro biofilm model system was reported when C. albicans was grown on cyclodextrin-functionalized polyethylene and polypropylene loaded with miconazole [51] or on polydimethyl siloxane disks impregnated with miconazole [17]. Polydimethyl siloxane disks were also used to covalently immobilize synthetic histatin-like [18] and newly engineered cationic tryptophan-rich peptides derived from the C-terminus of a human beta-defensin 28 variant [44]. C. albicans adhesion to and biofilm formation on the obtained biomaterials was reduced to various extents depending on the peptide and the type of the linker used.…”