Antimicrobial effects of Piper hispidum extract, fractions and chalcones against Candida albicans and Staphylococcus aureus

G, Costa; Endo, Eliana Harue; Cortez, Diógenes Aparı́cio Garcia; Ueda-Nakamura, Tânia; Nakamura, Celso Vataru

doi:10.1016/j.mycmed.2016.03.002

Cited by 23 publications

(11 citation statements)

References 46 publications

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“…Antibacterial activity of naturally occurring chalcones is well-documented in the literature [69,70] (Table 2). For example, 2 ,4 -dihydroxychalcone (51) isolated from Zuccagnia punctata; 3,2 -dihydroxy-2,4,4 ,6 -tetramethoxychalcone ( 55 The antibacterial activity of natural chalcones inspired synthetic chemists to attempt bioinspired synthesis of antibacterial chalcone derivatives.…”

Section: Antibacterial Activitymentioning

confidence: 97%

Chalcones: Synthetic Chemistry Follows Where Nature Leads

et al. 2021

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Chalcones belong to the flavonoid class of phenolic compounds. They form one of the largest groups of bioactive natural products. The potential anticancer, anti-inflammatory, antimicrobial, antioxidant, and antiparasitic properties of naturally occurring chalcones, and their unique chemical structural features inspired the synthesis of numerous chalcone derivatives. In fact, structural features of chalcones are easy to construct from simple aromatic compounds, and it is convenient to perform structural modifications to generate functionalized chalcone derivatives. Many of these synthetic analogs were shown to possess similar bioactivities as their natural counterparts, but often with an enhanced potency and reduced toxicity. This review article aims to demonstrate how bioinspired synthesis of chalcone derivatives can potentially introduce a new chemical space for exploitation for new drug discovery, justifying the title of this article. However, the focus remains on critical appraisal of synthesized chalcones and their derivatives for their bioactivities, linking to their interactions at the biomolecular level where appropriate, and revealing their possible mechanisms of action.

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Section: Antibacterial Activitymentioning

confidence: 97%

Chalcones: Synthetic Chemistry Follows Where Nature Leads

et al. 2021

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“…As the precursors of flavonoids that are widely found in plants, chalcones possess a relatively simple structure and diverse pharmacological effects, including antibacterial and antifungal activities (Alcaraz et al, 2004;Boeck et al, 2005;Chiaradia et al, 2008;Mascarello et al, 2010). As a derivative of chalcone, 2 -hydroxy-4, 4 , 6 -trimethoxychalcone can inhibit the growth of fungal pathogens (Costa et al, 2016). As a critical intermediate in the synthesis of lignin and alkaloids, p-coumaric acid plays an important role in plant defense responses.…”

Section: Phenolic Compoundsmentioning

confidence: 99%

Metabolomics analysis identifies metabolites associated with systemic acquired resistance in Arabidopsis

Gao

Zhou²,

Liu

et al. 2020

PeerJ

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Background Systemic acquired resistance (SAR) is a type of plant defense response that provides a long-lasting resistance to broad-spectrum pathogens in uninfected distal tissues following an initial localized infection. However, little information is available at present on the biological basis of SAR at the molecular level, especially in uninfected distal leaves. Methods In the present work, we used two SAR-inducing pathogens, avirulent Pseudomonas syringae pv. maculicola ES4326 harboring avrRpm1 (Psm avrRpm1) and virulent P. syringae pv. maculicola ES4326 (Psm ES4326), to induce SAR in Arabidopsis ecotype Col-0. A metabolomics approach based on ultra-high-performance liquid chromatography (UPLC) coupled with mass spectrometry (MS) was used to identify SAR-related metabolites in infected local leaves, and in uninfected distal leaves. Results Differentially accumulated metabolites were distinguished by statistical analyses. The results showed that both the primary metabolism and the secondary metabolism were significantly altered in infected local leaves and in uninfected distal leaves, including phenolic compounds, amino acids, nucleotides, organic acids, and many other metabolites. Conclusions The content of amino acids and phenolic compounds increased in uninfected distal leaves, suggesting their contribution to the establishment of SAR. In addition, 2′-hydroxy-4, 4′, 6′-trimethoxychalcone, phenylalanine, and p-coumaric acid were identified as potential components which may play important roles both in basic resistance and in SAR. This work provides a reference for understanding of the metabolic mechanism associated with SAR in plants, which will be useful for further investigation of the molecular basis of the systemic immunity.

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“…The A and B rings of chalcones are linked by a three-carbon chain instead of a C ring, which is absent (Veitch and Grayer, 2006 ). Chalcones have nutritional and biological benefits owing to their anti-bacterial and anti-parasitic activities (Nowakowska, 2007 ; Costa et al, 2016 ).…”

Section: Flavonoid Structure and Classificationmentioning

confidence: 99%

Flavonoids as a Natural Treatment Against Entamoeba histolytica

Martínez-Castillo

Pacheco‐Yépez

Flores-Huerta

et al. 2018

Front. Cell. Infect. Microbiol.

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Over the past 20 years, gastrointestinal infections in developing countries have been a serious health problem and are the second leading cause of morbidity among all age groups. Among pathogenic protozoans that cause diarrheal disease, the parasite Entamoeba histolytica produces amebic colitis as well as the most frequent extra-intestinal lesion, an amebic liver abscess (ALA). Usually, intestinal amebiasis and ALA are treated with synthetic chemical compounds (iodoquinol, paromomycin, diloxanide furoate, and nitroimidazoles). Metronidazole is the most common treatment for amebiasis. Although the efficacy of nitroimidazoles in killing amebas is known, the potential resistance of E. histolytica to this treatment is a concern. In addition, controversial studies have reported that metronidazole could induce mutagenic effects and cerebral toxicity. Therefore, natural and safe alternative drugs against this parasite are needed. Flavonoids are natural polyphenolic compounds. Flavonoids depend on malonyl-CoA and phenylalanine to be synthesized. Several flavonoids have anti-oxidant and anti-microbial properties. Since the 1990s, several works have focused on the identification and purification of different flavonoids with amebicidal effects, such as, -(-)epicatechin, kaempferol, and quercetin. In this review, we investigated the effects of flavonoids that have potential amebicidal activity and that can be used as complementary and/or specific therapeutic strategies against E. histolytica trophozoites. Interestingly, it was found that these natural compounds can induce morphological changes in the amebas, such as chromatin condensation and cytoskeletal protein re-organization, as well as the upregulation and downregulation of fructose-1,6-bisphosphate aldolase, glyceraldehyde-phosphate dehydrogenase, and pyruvate:ferredoxin oxidoreductase (enzymes of the glycolytic pathway). Although the specific molecular targets, bioavailability, route of administration, and doses of some of these natural compounds need to be determined, flavonoids represent a very promising and innocuous strategy that should be considered for use against E. histolytica in the era of microbial drug resistance.

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Antimicrobial effects of Piper hispidum extract, fractions and chalcones against Candida albicans and Staphylococcus aureus

Cited by 23 publications

References 46 publications

Chalcones: Synthetic Chemistry Follows Where Nature Leads

Chalcones: Synthetic Chemistry Follows Where Nature Leads

Metabolomics analysis identifies metabolites associated with systemic acquired resistance in Arabidopsis

Flavonoids as a Natural Treatment Against Entamoeba histolytica

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