Antimicrobial drugs bearing guanidine moieties: A review

Kim, Seong-Heun; Semenya, Dorothy; Castagnolo, Daniele

doi:10.1016/j.ejmech.2021.113293

Cited by 82 publications

(75 citation statements)

References 82 publications

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“…Guanidine analogs were widely reported as their significant antiviral and anticancer activities 91 , 92 . Methylglyoxal-bisguanylhydrazone (MAGA) has been used as a single drug in clinical therapy for malignant lymphoma, carcinoma of the head, oesophageal cancer, and non-small cell lung cancer 93 .…”

Section: Modification Of the α β-Unsaturated Carbonyl Bridges Of Chalconementioning

confidence: 99%

A review on synthetic chalcone derivatives as tubulin polymerisation inhibitors

Liu

et al. 2021

Journal of Enzyme Inhibition and Medicinal Chemistry

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Microtubules play an important role in the process of cell mitosis and can form a spindle in the mitotic prophase of the cell, which can pull chromosomes to the ends of the cell and then divide into two daughter cells to complete the process of mitosis. Tubulin inhibitors suppress cell proliferation by inhibiting microtubule dynamics and disrupting microtubule homeostasis. Thereby inducing a cell cycle arrest at the G2/M phase and interfering with the mitotic process. It has been found that a variety of chalcone derivatives can bind to microtubule proteins and disrupt the dynamic balance of microtubules, inhibit the proliferation of tumour cells, and exert anti-tumour effects. Consequently, a great number of studies have been conducted on chalcone derivatives targeting microtubule proteins. In this review, synthetic or natural chalcone microtubule inhibitors in recent years are described, along with their structure-activity relationship (SAR) for anticancer activity.

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Section: Modification Of the α β-Unsaturated Carbonyl Bridges Of Chalconementioning

confidence: 99%

A review on synthetic chalcone derivatives as tubulin polymerisation inhibitors

Liu

et al. 2021

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…Figure 9 shows some chemical structures for cationic APs with sulfonium, phosphonium, or guanidinium as the cationic moiety. From left to right, some cationic polymers with different cationic moieties such as sulfonium [139,140], phosphonium [142], and guanidinium [141,144].…”

Section: Asas With Apsmentioning

confidence: 99%

“…Guanidinium polymers were successfully used to target intracellular, multidrug−resistant Staphylococcus aureus [149]. Non−leaching polyacrylate and guanidine−based copolymer NPs with 80-130 nm mean diameter were synthesized by emulsion polymerization with From left to right, some cationic polymers with different cationic moieties such as sulfonium [139,140], phosphonium [142], and guanidinium [141,144].…”

Section: Biomedical Applications For Asa With Apsmentioning

confidence: 99%

Antimicrobial Polymer−Based Assemblies: A Review

Carmona-Ribeiro

Araújo

2021

IJMS

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An antimicrobial supramolecular assembly (ASA) is conspicuous in biomedical applications. Among the alternatives to overcome microbial resistance to antibiotics and drugs, ASAs, including antimicrobial peptides (AMPs) and polymers (APs), provide formulations with optimal antimicrobial activity and acceptable toxicity. AMPs and APs have been delivered by a variety of carriers such as nanoparticles, coatings, multilayers, hydrogels, liposomes, nanodisks, lyotropic lipid phases, nanostructured lipid carriers, etc. They have similar mechanisms of action involving adsorption to the cell wall, penetration across the cell membrane, and microbe lysis. APs, however, offer the advantage of cheap synthetic procedures, chemical stability, and improved adsorption (due to multipoint attachment to microbes), as compared to the expensive synthetic routes, poor yield, and subpar in vivo stability seen in AMPs. We review recent advances in polymer−based antimicrobial assemblies involving AMPs and APs.

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“…Many synthetic drug molecules, including benexate (anti‐ulcer), tiotidine (histamine H 2 ‐receptor antagonist), proguanil (anti‐malaria), pinacidil (high blood pressure), sulfaguanidine (bacillary dysentery), and many more contain guanidine unit (Figure 1). [5,6] Additionally, guanidine moieties also have been used in catalysis, [7] supramolecular and material chemistry [8]…”

Section: Introductionmentioning

confidence: 99%

Direct Synthesis of Sulfonimidoyl Guanidines from Sulfonimidoyl Azides under Dual (Cobalt and Photoredox) Catalysis

et al. 2022

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A visible‐light (456 nm) promoted dual catalytic (cobalt‐/photoredox) method for the direct synthesis of sulfonimidoyl guanidine via three‐component reaction of aryl amine, isonitrile and sulfonimidoyl azide (as nitrene source) is developed. The protocol is fast, mild and provides products with a wide range of substrates in 56–86% yields. Additionally, the replacement of aryl amine with alcohol and thiol as nucleophile leads to the formation of sulfonimidoyl isourea and sulfonimidoyl isothiourea respectively, which are not yet reported in the literature.

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Antimicrobial drugs bearing guanidine moieties: A review

Cited by 82 publications

References 82 publications

A review on synthetic chalcone derivatives as tubulin polymerisation inhibitors

A review on synthetic chalcone derivatives as tubulin polymerisation inhibitors

Antimicrobial Polymer−Based Assemblies: A Review

Direct Synthesis of Sulfonimidoyl Guanidines from Sulfonimidoyl Azides under Dual (Cobalt and Photoredox) Catalysis

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