Antimicrobial coating of spider silk to prevent bacterial attachment on silk surgical sutures

Franco, Albina R.; Fernandes, Emanuel M.; Rodrigues, Márcia T.; Rodrigues, Fernando; Gomes, Manuela E.; Leonor, Isabel B.; Kaplan, David L.; Reis, Rui L.

doi:10.1016/j.actbio.2019.09.004

Cited by 83 publications

(72 citation statements)

References 65 publications

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“…In 1998, Bickel et al reported a subcutaneous "spider silk" suture to address the thread easily break and discomfort of long incisions in patients, and there were no related complications within 10 years [56]. There is literature regarding the use of spider silk as an antibacterial coating on silk surgical sutures demonstrates to prevent bacterial attachment in the recent [57]. The overall reported of the above suggested the great benefits of natural spider silk as suture materials.…”

Section: Application Of Natural Spider Silkmentioning

confidence: 99%

The Outlook of the Development of Innovative Products from Biocompatible Natural Spider Silk in the Beauty Thread-Lifting Industry

Chen

Xue

et al. 2021

Nat. Prod. Bioprospect.

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Embedding thread lift rhytidectomy, also known as “thread lifting” in China, with the natures of simple operation, less trauma and quick recovery, is progressively used in clinical practice as a new technology of face lifting. Herewith, a brief introduction of the previous advances of thread lifting techniques and materials in the facial beauty industry, combined with the discussion on various types of sutures, common complications, and the site of actions were provided. The main limitations of present thread lifting material include: (1) the use of non-absorbable sutures is liable to cause allergies and a series of complications; (2) the absorbable sutures are easily degradation, and people need to reshape in a relatively short period. Therefore, the high biocompatible spider silk was proposed as a novel material of thread lifting suture and related devices, the advantages and preliminary achievements on spider silk were also addressed. Graphic Abstract

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Section: Application Of Natural Spider Silkmentioning

confidence: 99%

The Outlook of the Development of Innovative Products from Biocompatible Natural Spider Silk in the Beauty Thread-Lifting Industry

Chen

Xue

et al. 2021

Nat. Prod. Bioprospect.

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“…Finally, Franco et al. [ 25 ] published an innovative work using the dip‐coating technique to coat commercial silk suture threads. Bioengineered spider silk proteins with antimicrobial peptides (AMP 6mer‐HNP1) was used as an antibacterial drug‐free coating to decrease bacterial infections.…”

Section: Coating Of the Commercially Available Suture Threadsmentioning

confidence: 99%

New Strategies for the Development of Multifunctional Suture Threads

Tranquillo

Bollino

2021

Macromolecular Symposia

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Surgical site infection (SSI) is one of the most frequently reported types of hospital-acquired infections, associated with severe morbidity and sometimes mortality. It leads to an increase in the clinical and economic burden of surgery, due to the direct costs incurred by prolonged hospitalization, diagnostic tests, outpatient visits, systemic antibiotic treatments, and often reoperations. The SSI is frequently caused by the suture threads material which can become an infection vector. The present mini-review shows how the research is bringing new skills and knowledge in the design of new suture threads for SSI prevention and the wound healing process improvement.

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“…Surgical site infection hast been assessed to arise in 5% of all medical procedures in hospitals [ 7 ], resulting in pain and discomfort for the patients and prolonged hospitalization and additional costs to the health system [ 8 ]. Not only implanted foreign bodies, yet also suture material have to be taken into consideration as a host for biofilm and therefore a potential source of infection [ 7 , 9 , 10 ]. In order to surmount this issue, the coating of suture material not only with chemicals such as triclosan [ 11 – 16 ], yet also with metal legions is not uncommon in medicine.…”

Section: Introductionmentioning

confidence: 99%

Scar quality examination comparing titanium-coated suture material and non-coated suture material on flap donor sites in reconstructive surgery

et al. 2020

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Background Wound healing and scar quality after trauma are subject to impairment through excessive wound healing, chronic wound or even surgical site infections. Optimizing the process of scar formation and skin healing is crucial in virtually all fields of medicine. In this regard, we tested the possible usage and advantages of titanium coated suture material. Methods We performed a prospective observational cohort study including 30 patients who underwent soft tissue reconstruction. One half of the donor flap site was sutured with titanium coated suture material, while the other half was closed with non-coated sutures. Scar quality of the donor flap site was assessed by photographs and POSAS scores on days 2–5, 14, 42, 72 and 180 postoperatively. Results No difference between the titanium coated sutures and non-coated sutures was seen in the POSAS assessment, neither for the patient scale at 14, 42, 72 and 180 days, nor for the observer scale on the same dates. Comorbidities like diabetes, chronic renal failure and smoking as well as the BMI of each patient affected the wound healing process to an equal degree on both sides of the suture. Conclusions No difference between the titanium coated and non-titanium-coated suture material was seen in the POSAS assessment in regard to scar quality and wound healing. The titanium-coated suture material can be considered to be equally as effective and safe in all qualities as the non-titanium-coated suture material, even in patients with comorbidities. Clinical trial register This study is registered at the German Clinical Trials Register (DRKS) under the registration number DRKS00021767. (https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00021767)

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Antimicrobial coating of spider silk to prevent bacterial attachment on silk surgical sutures

Cited by 83 publications

References 65 publications

The Outlook of the Development of Innovative Products from Biocompatible Natural Spider Silk in the Beauty Thread-Lifting Industry

The Outlook of the Development of Innovative Products from Biocompatible Natural Spider Silk in the Beauty Thread-Lifting Industry

New Strategies for the Development of Multifunctional Suture Threads

Scar quality examination comparing titanium-coated suture material and non-coated suture material on flap donor sites in reconstructive surgery

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