Antimicrobial and Biocatalytic Potential of Haloalkaliphilic Actinobacteria

Gohel, Sangeeta D.; Sharma, Amit; Dangar, Kruti G.; Thakrar, Foram J.; Singh, Satya P.

doi:10.1007/978-3-319-14595-2_2

Cited by 13 publications

(2 citation statements)

References 178 publications

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“…Protease plays a significant role in the metabolic cycles of all living forms. There are several types of proteases including serine, carboxy serine, cystine, metallo, carboxy metallo, and aspartic proteases [71]. The application of protease includes animal fodder preparation, silk degumming, detergent formulation (stain remover), dehairing and dewooling (leather industry), and silver recovery from X-ray film [72][73][74].…”

Section: Enzymesmentioning

confidence: 99%

Actinobacteria Associated with Marine Invertebrates: Diversity and Biological Significance

Majithiya¹,

Gohel²

2022

Actinobacteria - Diversity, Applications and Medical Aspects

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The ocean harbors a wide diversity of beneficial fauna offering an enormous resource for novel compounds, and it is classified as the largest remaining reservoir of natural molecules to be evaluated for biological activity. The metabolites obtained from marine invertebrate-associated actinobacteria have different characteristics compared to terrestrial actinobacteria as marine environments are exigent and competitive. Actinobacteria produce a wide range of secondary metabolites, such as enzymes, antibiotics, antioxidative, and cytotoxic compounds. These allelochemicals not only protect the host from other surrounding pelagic microorganisms but also ensure their association with the host. The harnessing of such metabolites from marine actinobacteria assures biotechnological, agricultural, and pharmaceutical applications.

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Section: Enzymesmentioning

confidence: 99%

Actinobacteria Associated with Marine Invertebrates: Diversity and Biological Significance

Majithiya¹,

Gohel²

2022

Actinobacteria - Diversity, Applications and Medical Aspects

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“…C. albicans was also inhibited by halophilic actinobacterial strain H262 from Algerian arid habitats of the Sahara desert with a 17 mm inhibition zone, 19 mm for Penicillium expansum fungi PE1, 31 mm for the bacterium B. subtilis, and 37 mm for MRSA [71]. Moreover, Gohel et al ( 2015) [72] provided a thorough description of the antibacterial activity of haloalkaliphilic actinobacteria. Extensively, halophilic Proteobacteria have already been shown to synthesise a variety of natural compounds [73].…”

Section: Biopotency Of Halophiles As Antibacterials For Clinical Drug...mentioning

confidence: 99%

Recent Antimicrobial Responses of Halophilic Microbes in Clinical Pathogens

et al. 2022

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Microbial pathogens that cause severe infections and are resistant to drugs are simultaneously becoming more active. This urgently calls for novel effective antibiotics. Organisms from extreme environments are known to synthesize novel bioprospecting molecules for biomedical applications due to their peculiar characteristics of growth and physiological conditions. Antimicrobial developments from hypersaline environments, such as lagoons, estuaries, and salterns, accommodate several halophilic microbes. Salinity is a distinctive environmental factor that continuously promotes the metabolic adaptation and flexibility of halophilic microbes for their survival at minimum nutritional requirements. A genetic adaptation to extreme solar radiation, ionic strength, and desiccation makes them promising candidates for drug discovery. More microbiota identified via sequencing and ‘omics’ approaches signify the hypersaline environments where compounds are produced. Microbial genera such as Bacillus, Actinobacteria, Halorubrum and Aspergillus are producing a substantial number of antimicrobial compounds. Several strategies were applied for producing novel antimicrobials from halophiles including a consortia approach. Promising results indicate that halophilic microbes can be utilised as prolific sources of bioactive metabolites with pharmaceutical potentialto expand natural product research towards diverse phylogenetic microbial groups which inhabit salterns. The present study reviews interesting antimicrobial compounds retrieved from microbial sources of various saltern environments, with a discussion of their potency in providing novel drugs against clinically drug-resistant microbes.

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