Antimicrobial Activity of Seaweeds Against Multi Drug Resistant Strains

Manikandan, S.; Ganesapand, S.; Singh, Manoj; Sangeetha, N.; Kumaraguru, A. K.

doi:10.3923/ijp.2011.522.526

Cited by 23 publications

(12 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Plant, 9 (6): 275-283, 2015(Azoro, 2002. Various studies have been published, investigating the antifungal and antibacterial activities of plant derived compounds against a range of pathogens (Tassou et al, 2000;Friedman et al, 2002;Momtaz and Abdollahi, 2010;Ara et al, 2009;Manikandan et al, 2011). Antimicrobial compounds derived from plants might inhibit bacteria through different mechanisms and provide clinical values for the treatment of infection caused by resistant microbes (Stein et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Screening, Antifungal and Antibacterial Activity of Aqueous and Ethanolic Leaf and Stem Extracts of Gnetum africanum Welw

Ilodibia¹,

Ugwu²,

Nwokolo³

et al. 2015

Research J. of Medicinal Plant

View full text Add to dashboard Cite

Aqueous and ethanolic leaf and stem extracts of Gnetum africanum were investigated for the presence and composition of these phytochemicals (alkaloid, flavonoid, tannin, phenol, saponin, sterol, terpenoid and cyanogenic glycoside) and their antifungal and antibacterial activities at various concentrations against some selected clinical microbes (fungal strains: Candida albicans and Aspergillus niger and bacterial strains: Staphylococcus aureus, Escherichia coli and Salmonella typhi) using standard methods. Analysis of variance (ANOVA) was employed in data analysis. Qualitative and percent quantitative phytochemical results showed that both the aqueous and ethanolic leaf and stem extracts contained these phytochemicals assayed but at varied quantities except cyanogenic glycoside. Antifungal and antibacterial studies indicated that both the aqueous and ethanolic leaf and stem extracts of Gnetum africanum inhibited the growth of the microbes but at varied levels and the inhibition was extracts concentration dependent. However, both the aqueous and ethanolic leaf and stem extracts showed no inhibition against the bacterial strains at 50 mg mLG 1 of the extracts. The extracts showed higher inhibition against the fungal strains than the bacterial strains. Inhibitory effect of the leaf extract was significantly higher than those of the stem extract. The ethanol extract showed significantly higher inhibition than the aqueous extract. Antibiotics had a better activity when compared to the extracts at the same concentration. Gnetum africanum extracts were biostatic in their action, when purified will give a product with higher activity. The data obtained from the study indicated that the plant possessed antifungal and antibacterial potentials especially antifungal and could be used as natural fungicides.

show abstract

Section: Introductionmentioning

confidence: 99%

Phytochemical Screening, Antifungal and Antibacterial Activity of Aqueous and Ethanolic Leaf and Stem Extracts of Gnetum africanum Welw

Ilodibia¹,

Ugwu²,

Nwokolo³

et al. 2015

Research J. of Medicinal Plant

View full text Add to dashboard Cite

show abstract

“…Fungal infections have outstandingly increased in both developing and developed countries with the increase in the numbers of immunocompromised individuals in epidemic human immunodeficiency viral (HIV) infections (MEENA et al, 2009). While previously uncommon fungi which are difficult to manage and insidious opportunistic fungal infections caused by Aspergillus and Candida species are customarily accountable for the greater part of morbidity and mortality recorded in individuals undergoing haematopoetic stem cell transplantation (VISCOLI et al, 1999;GROLL and WALSH, 2001), the rising occurrence of fungal pathogens resistant to antifungal drugs has also become a great concern (MANIKANDAN et al, 2011). Consequently, while the administration of systemic drugs has become therapeutically inadequate due to increased level of toxicity and associated problems of residues in products intended for human consumption (ARAÚJO et al, 2009), many aboriginal plants species widely described is now being required for treatment of infections (LEE et al, 2007;VIGNESH et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Antimycotic and cytotoxicological potentials of Acacia mearnsii de wild. stem bark extract: In vitro assessment

Olajuyigbe¹,

Adeoye-Isijola²,

Coopoosamy³

2019

Kragujevac J Science

View full text Add to dashboard Cite

Despite using antimycotic drugs in the treatment of dermatomycoses as an age long practice, the fungicidal activities of indigenous plants on spores of dermatophytes from germinating in vitro need to be investigated further. In this study, methanol extract of Acacia mearnsii was assessed for its antifungal activity against dermatophytic pathogenic fungi by agar diffusion and broth dilution methods. The cytotoxicity activity of the extract was determined by the brine shrimp lethality assay. The study showed that the mean ± standard deviation of the inhibition zones ranged between 13 and 24 ± 0.58 mg/ml and the activity of the extract was concentration dependent. While the minimum inhibitory concentration (MIC) was 0.3125-2.5 mg/ml, the minimum fungicidal concentration (MFC) values ranged between 0.3125 mg/ml and 5 mg/ml. The susceptibility of the yeast to the extract was more than those of the molds. The MIC of the yeasts ranged between 0.3125 and 1.25 mg/ml while those of the molds ranged between 0.625 and 2.5 mg/ml. The mechanism of antibiosis showed that the extract was 7.69% fungistatic and 92.31% fungicidal wielding more killing effects on the fungi than potentiating their growth. The cytotoxicity assay showed that the crude methanolic extract with the LC 50 being 101.59 µg/ml was pharmacologically active and nontoxic (LC 50 > 100 μg/ml). The antifungal activity of this plant can be exploited as an alternative or complementary means of treating fungal infections to eliminate fungal spread. The study further justified the folkloric use of A. mearnsii in the treatment of a variety of microbial infections.

show abstract

“…Several plants species have been tested for antimicrobial properties, but vast majorities have not yet been adequately evaluated [3]. Various studies have been published, investigating the antifungal and antibacterial activities of plant-derived compounds against a range of pathogens [4][5][6][7][8]. Different substances have been identified in medicinal plants which are believed to be the antimicrobial agent, and these include different forms of alkaloids, diterpenes, saponins, flavonoids, sterols, quinines, different forms of other proteins as well as lipids [9].…”

Section: Introductionmentioning

confidence: 99%

In-Vitro Antioxidant Activity of Canna Indica Extracts Using Different Solvent System

Singh

Singh²,

Bachheti

et al. 2016

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: To investigate the antimicrobial and antidiabetic potential of canna indica plant extracts.Methods: In the present research work the selected plant i.e. Canna indica L. Cannaceae was collected, dried and extracted with different solvents. Different test were performed for the presence of different phytochemicals. The antimicrobial activity was determined by agar well-diffusion method. The extracts were evaluated for antidiabetic activity by using alpha-amylase and alpha-glucosidase enzyme inhibition method.Results and conclusion: The findings of the present study indicate that C. indica extracts contain secondary metabolites which have potent antimicrobial and antidiabetic activities comparable to standard drugs. This information may help to develop potent bioactive compound(s) in the pharmaceutical industry for the development of drugs.

show abstract

Antimicrobial Activity of Seaweeds Against Multi Drug Resistant Strains

Cited by 23 publications

References 18 publications

Phytochemical Screening, Antifungal and Antibacterial Activity of Aqueous and Ethanolic Leaf and Stem Extracts of Gnetum africanum Welw

Phytochemical Screening, Antifungal and Antibacterial Activity of Aqueous and Ethanolic Leaf and Stem Extracts of Gnetum africanum Welw

Antimycotic and cytotoxicological potentials of Acacia mearnsii de wild. stem bark extract: In vitro assessment

In-Vitro Antioxidant Activity of Canna Indica Extracts Using Different Solvent System

Contact Info

Product

Resources

About