Antimicrobial activity of Mitracarpus scaber extract and isolated constituents

Abstract

activity of a methanol extract and isolated constituents of Mitracarpus scaber, a species used in folk medicine by West African native people, was evaluated against Staphylococcus aureus and Candida albicans strains. The mitracarpus methanol extract possesses both antibacterial and antimycotic activities (minimum inhibitory concentration-MIC 31·25 and 62·50 mg ml −1 , respectively). This extract was subsequently fractioned and monitored by bioassays leading to the isolation of seven compounds screened for antibacterial and antimycotic activities. Among these compounds, gallic acid and 3,4,5-trimethoxybenzoic acid inhibited the growth of Staph. aureus (MIC 3·90 and 0·97 mg ml −1 ). 4-Methoxyacetophenone and 3,4,5-trimethoxyacetophenone effectively inhibited C. albicans (MIC 1·95 mg ml −1 ). The other compounds (kaempferol-3-O-rutinoside, rutin and psoralen) which were also isolated showed low antibacterial and antimycotic activities (125-500 mg ml −1 ).

Substâncias químicas com atividades alelopáticas presentes nas folhas de Parkia pendula (Leguminosae)

“…O conjunto dessas informações espectrais permite indicar a substância S1 como o ácido 3,4,5-trimetoxibenzóico -ver estrutura na Figura 3. Em recentes pesquisas, essa substância apresentou atividade antimicrobiana, inibindo o crescimento de Staphylococus aureus (Besigmano et al, 2000).…”

Pharmacognostic evaluation of the leaves of <i>Mitracarpus scaber</i> Zucc (Rubiaceae)

“…Phytochemical evaluation revealed the presence of tannins which have been claimed to be responsible for its antimicrobial activity 10 .…”

Antibacterial activity of <i>Terminalia glaucescens</i>, <i>Mangifera indica</i> and <i>Mitracarpus villosus</i> on carbapenem-resistant enterobacteriaceae

“…Mitracarpus villosus is a member of the family Rubiaceae. In various parts of tropical Africa, it is traditionally used for treatment of sore throat, ringworm and eczema, fresh cuts, wounds and ulcer (9,10,11). Previous studies also revealed that the plant contains biologically active substances such as fatty acids, flavonoids and other phenolic compounds with potential antifungal, antimicrobial and anti-inflammatory activities (12,13,14,15,16,17).…”