2010
DOI: 10.1590/s1678-91992010000400012
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Abstract: Some snake venom proteins present enzymatic activities, such as L-amino acid oxidase (LAAO). The aim of this paper was to investigate the effect of Bothrops leucurus total venom (BleuTV) and its fraction LAAO (BleuLAAO) on bacteria, yeast, and promastigote forms of Leishmania amazonensis and Leishmania chagasi, and epimastigote forms of Trypanosoma cruzi. BleuTV was isolated with a Protein Pack 5PW® (Waters Corporation, USA), and several fractions were obtained. BleuLAAO was purified to high molecular homogene… Show more

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Cited by 15 publications
(10 citation statements)
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“…Similar results were previously described in bioassays with venoms (Bustillo et al, 2008;Afc et al, 2010). One explanation for this situation is the existence of an optimal concentration for inhibition or that interactions between the venom compounds at different concentrations cause interference with growth inhibition (Haeberli et al, 2000;KuhnNentwig et al, 2012;Ciscotto et al, 2009).…”
Section: Discussionsupporting
confidence: 73%
“…Similar results were previously described in bioassays with venoms (Bustillo et al, 2008;Afc et al, 2010). One explanation for this situation is the existence of an optimal concentration for inhibition or that interactions between the venom compounds at different concentrations cause interference with growth inhibition (Haeberli et al, 2000;KuhnNentwig et al, 2012;Ciscotto et al, 2009).…”
Section: Discussionsupporting
confidence: 73%
“…Therefore, B. subtilis was susceptible to BlL. Recently, Torres et al (2010) showed that Bothrops leucurus total venom (BleuTV) inhibited the growth of S. aureus. Therefore, according to our results we can suggest that BlL is involved in the antibacterial activity of the venom.…”
Section: Resultsmentioning
confidence: 99%
“…B. leucurus was responsible for all cases of envenomation from snakebite recorded in the metropolitan region of Salvador (State of Bahia, northeastern Brazil) from January to June 1990 (Lira-da- Silva and Nunes, 1993) and an epidemiological study in Bahia in 2001 revealed that this species was responsible for all confirmed cases of envenomation by Bothrops species in this state (Mise et al, 2007). Recently, active components from B. leucurus venom were isolated, including a fibrinolytic proteinase (Bello et al, 2006), a thrombin-like enzyme (Magalhães et al, 2007), phospholipase A 2 (Higuchi et al, 2007), a P-III metalloproteinase (Sanchez et al, 2007), L-amino acid oxidases (Silva et al, 2007;Torres et al, 2010) as well as the metalloproteinases leucurolysin-a (Gremski et al, 2007;Ferreira et al, 2009) and BleucMP (Gomes et al, 2011).…”
Section: Introductionmentioning
confidence: 99%
“…LAAO from B. marajoensis venom was isolated and purified as described by Torres et al (2010) and was kindly donated by Dr. Marcos H. Toyama (Paulista State University, UNESP, São Paulo, Brazil).…”
Section: Laaobmmentioning
confidence: 99%