Antimicrobial activity and mechanism of Magnolia officinalis root extract against methicillin-resistant Staphylococcus aureus based on mannose transporter

Sun, Jutang; Xie, Yunfei; Chen, Zhiyuan; Fan, Yanping; Liu, Yunfeng; Gao, Qi; Li, Jianqiang; Bai, Jingwen; Yang, Yu

doi:10.1016/j.indcrop.2023.116953

Cited by 2 publications

(1 citation statement)

References 40 publications

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“…However, the same study found that magnolol and honokiol were less effective against other bacteria, such as Shigella flexneii, Staphylococcus epidermidis, Enterobacter aerogenes, Proteus vulgaris, Escherichia coli, and Pseudomonas aeruginosa, with MIC values of 100 µg/mL or higher, indicating relatively lower efficacy against these strains. Subsequent studies recognized and confirmed the antimicrobial qualities of phytochemical compounds of Magnolias extracts [50,51].…”

Section: Discussionmentioning

confidence: 84%

Phytochemical Analysis and Specific Activities of Bark and Flower Extracts from Four Magnolia Plant Species

Cristea,

Sava,

Căpățână

et al. 2024

Horticulturae

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This study rigorously investigates the bioactive properties and characteristics of extracts derived from the flowers and bark of four distinct Magnolia species: Magnolia champaca, Magnolia denudata, Magnolia grandiflora and Magnolia officinalis. The primary objective is to evaluate the potential application of these extracts in cosmetics and other relevant industries. We used ethanol to extract compounds from these plants and conducted various tests, including spectrophotometry, HPLC, GC-MS, and microbiological analyses. The extracts, particularly rich in polyphenols (55.18 mg GAE/g), displayed significant antioxidant capabilities, with IC 50 values ranging between 9.99 mg/mL and 23.23 mg/mL. We quantified different compounds: phenolic acids (6.259 to 27.883 mg/g dry weight), aglycone flavonoids (61.224 to 135.788 mg/g dw), glycosidic flavonoids (17.265 to 57.961 mg/g dw), and lignans (150.071 to 374.902 mg/g dw). We identified 76 volatile compounds, predominantly oxygenated monoterpenes and sesquiterpene hydrocarbons, which contribute to the antibacterial effectiveness of the extracts. These extracts showed greater inhibitory potential against Gram-negative bacteria than Gram-positive bacteria. The diverse chemical compounds and their demonstrated activities suggest these extracts could be valuable in the cosmetics industry, pharmaceutical industry, or other industries.

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Section: Discussionmentioning

confidence: 84%

Phytochemical Analysis and Specific Activities of Bark and Flower Extracts from Four Magnolia Plant Species

Cristea,

Sava,

Căpățână

et al. 2024

Horticulturae

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Enhancement of lemongrass essential oil physicochemical properties and antibacterial activity by encapsulation in zein-caseinate nanocomposite

Alsakhawy,

Baghdadi,

El-Shenawy

et al. 2024

Sci Rep

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Essential oils (EOs) represent a pivotal source for developing potent antimicrobial drugs. However, EOs have seldom found their way to the pharmaceutical market due to their instability and low bioavailability. Nanoencapsulation is an auspicious strategy that may circumvent these limitations. In the current study, lemongrass essential oil (LGO) was encapsulated in zein-sodium caseinate nanoparticles (Z-NaCAS NPs). The fabricated nanocomposite was characterized using dynamic light scattering, Fourier-transform infrared spectroscopy, differential scanning calorimetry, and transmission electron microscopy. The antimicrobial activity of LGO loaded NPs was assessed in comparison to free LGO against Staphylococcus epidermidis, Enterococcus faecalis, Escherichia coli, and Klebsiella pneumoniae. Furthermore, their antibacterial mechanism was examined by alkaline phosphatase, lactate dehydrogenase, bacterial DNA and protein assays, and scanning electron microscopy. Results confirmed the successful encapsulation of LGO with particle size of 243 nm, zeta potential of – 32 mV, and encapsulation efficiency of 84.7%. Additionally, the encapsulated LGO showed an enhanced thermal stability and a sustained release pattern. Furthermore, LGO loaded NPs exhibited substantial antibacterial activity, with a significant 2 to 4 fold increase in cell wall permeability and intracellular enzymes leakage versus free LGO. Accordingly, nanoencapsulation in Z-NaCAS NPs improved LGO physicochemical and antimicrobial properties, expanding their scope of pharmaceutical applications.

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Antimicrobial activity and mechanism of Magnolia officinalis root extract against methicillin-resistant Staphylococcus aureus based on mannose transporter

Cited by 2 publications

References 40 publications

Phytochemical Analysis and Specific Activities of Bark and Flower Extracts from Four Magnolia Plant Species

Phytochemical Analysis and Specific Activities of Bark and Flower Extracts from Four Magnolia Plant Species

Enhancement of lemongrass essential oil physicochemical properties and antibacterial activity by encapsulation in zein-caseinate nanocomposite

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