Antimescaline properties of some lysergic acid derivatives

Borsy, J.; Huszti, Zs.; Fekete, M. A. R. de

doi:10.1016/0028-3908(63)90002-9

Cited by 8 publications

(2 citation statements)

References 6 publications

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“…It should be noted that the ESR is not induced by indoleamine hallucinogens (Yim et al, 1979). In fact, LSD and 5-MeO-DMT actually block the ESR induced by mescaline, DOM, and DOI (Chen and Bohner, 1960; Borsey et al, 1964; Darmani et al, 1990b). Based on the finding that the DOI-induced ESR is also inhibited by the 5-HT 1A/1B agonist RU 24969 but not by the 5-HT 1A agonist 8-OH-DPAT (Darmani et al, 1990b), it appears that blockade of the ESR by the indoleamine hallucinogens involves interactions between 5-HT 2A and 5-HT 1B receptors.…”

Section: Behavioral Effects Of Hallucinogensmentioning

confidence: 99%

Multiple receptors contribute to the behavioral effects of indoleamine hallucinogens

2011

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Serotonergic hallucinogens produce profound changes in perception, mood, and cognition. These drugs include phenylalkylamines such as mescaline and 2,5-dimethoxy-4-methylamphetamine (DOM), and indoleamines such as (+)-lysergic acid diethylamide (LSD) and psilocybin. Despite their differences in chemical structure, the two classes of hallucinogens produce remarkably similar subjective effects in humans, and induce cross-tolerance. The phenylalkylamine hallucinogens are selective 5-HT2 receptor agonists, whereas the indoleamines are relatively non-selective for serotonin (5-HT) receptors. There is extensive evidence, from both animal and human studies, that the characteristic effects of hallucinogens are mediated by interactions with the 5-HT2A receptor. Nevertheless, there is also evidence that interactions with other receptor sites contribute to the psychopharmacological and behavioral effects of the indoleamine hallucinogens. This article reviews the evidence demonstrating that the effects of indoleamine hallucinogens in a variety of animal behavioral paradigms are mediated by both 5-HT2 and non-5-HT2 receptors.

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Section: Behavioral Effects Of Hallucinogensmentioning

confidence: 99%

Multiple receptors contribute to the behavioral effects of indoleamine hallucinogens

2011

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“…It was observed, however, that mescaline inhibited the isolation-induced attack behavior of mice (3 18). It produced a scratching response in mice, which was antagonized by tetrahydroberberine (3 19), various tranquilizers, serotonin, d-amphetamine, etc., but not by barbiturates, meprobamate, azacyclonol, and mephenesin (320)(321)(322). Mescaline, given by intracerebral injection, produced aggressive tendencies and paroxysms of ear scratching in mice by doses that were ineffective by other routes (323).…”

Section: Biological Effects Of Peyote Alkaloidsmentioning

confidence: 99%