Antimalarial Anthrone and Chromone from the Leaf Latex of &lt;i&gt;Aloe debrana&lt;/i&gt; Chrstian

Gemechu, Worku; Bisrat, Daniel; Asres, Kaleab

doi:10.4314/epj.v30i1.1

Cited by 12 publications

(14 citation statements)

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“…This show that Aloe weloensis is endowed with a very good antimalarial activity and concordant to promising antimalarial activity of Aloe vera, Aloe pulcherrima and Aloe megalacantha in the genus Aloe (19)(20)(21). In another studies, signi cant dose-dependent parasite suppression was demonstrated after administration of Aloe macrocarpa, Aloe debrana and Aloe sinana which indicate a promising antimalarial activity and providing the scienti c evidence for the folkloric use of the plant (41,42).…”

Section: Discussionsupporting

confidence: 56%

Evaluation of in vitro and in vivo Antiplasmodial Activity of the Leaf Latex of Aloe Weloensis (Aloaceae)

Amare

Awgichew

Ahmed

et al. 2020

Preprint

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Background: Nature has gifted a variety of plants having potential effect against plasmodium parasites. The present study was aimed to determine in vitro and in vivo antimalarial activity of the leaf latex of Aloe weloensis.Methods: In vitro antimalarial activity of the leaf latex of A. weloensis was determined against 3D7 strain of P. falciparum. Antimalarial activity of the three doses the latex was evaluated in 4 day-suppressive and curative models against P. berghei infected mice. Antioxidant activity of the leaf latex of A. weloensis was assessed in 2,2- diphenyl 1- picrylhydrazine assay model. Results: Antioxidant activity of the latex was concentration dependent; the strongest inhibition was measured at 400 μg/mL (73.54%). The leaf latex of A. weloensis was demonstrated inhibitory activity against 3D7 malarial strain (IC50 = 9.14 μg/ml). Suppressive and curative effect of the latex was found to be dose dependent. Parasitemia reduction was significant (200 mg/kg, p<0.01, 400 and ,600 mg/kg, p<0.001) in 4-day suppressive test compared to vehicle control. Parasitemia level of the mice treated with 200, 400 and 600 mg/kg doses of the latex significantly (p<0.001) reduced with suppression of 36%, 58% and 64% respectively in curative test. Administration of the leaf latex of A. weloensis significantly (p<0.01) improved mean survival time, pack cell volume, rectal temperature and body weight of P. berghei infected mice. Conclusion: The finding showed that the leaf latex of Aloe weloensis endowed prominent antimalarial and antioxidant activities. The result can serve as a step towards the development of safe and effective herbal therapy against plasmodium parasites.

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Section: Discussionsupporting

confidence: 56%

Evaluation of in vitro and in vivo Antiplasmodial Activity of the Leaf Latex of Aloe Weloensis (Aloaceae)

Amare

Awgichew

Ahmed

et al. 2020

Preprint

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“…In Ethiopia and Eritrea, about 46 species of Aloe have been described so far with a high proportion of endemics adapted to harsh climates [10]. It has been reported that the leaf latex of several Aloe species and their constituents possess wide spectrum of biological activities, such as antimicrobial [11, 12], antimalarial [13], and antiglycation [14]. …”

Section: Introductionmentioning

confidence: 99%

Structural elucidation of some antimicrobial constituents from the leaf latex of Aloe trigonantha L.C. Leach

Megeressa

Bisrat

Mazumder³

et al. 2015

BMC Complement Altern Med

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BackgroundThe incidents of drug resistant microorganisms and the need of treatments for newly emerging pathogens are of great concern to the global community. Our ability to treat infectious diseases is dependent on the development of new pharmaceuticals, and one potential source being medicinal plants with traditional claims. The leaves of Aloe trigonantha L.C. Leach, an endemic Ethiopian plant, are locally used for the treatment of infectious and inflammatory diseases. This study explores the potential of the latex of this plant and compounds isolated thereof for their in vitro antibacterial and antifungal properties.MethodsAnalytical RP-HPLC and silica gel preparative TLC were used for identification and isolation of active constituents, respectively. Characterization of the compounds was based on UV, IR, HR-ESIMS, 1H and 13C NMR, and 2D-NMR spectral assignments. Antimicrobial activity studies were carried out against 21 pathogenic bacterial and 4 fungal strains using the disk diffusion method. Minimum inhibitory concentrations (MICs) were determined by the broth dilution method.ResultsA C-glycosylated chromone identified as aloesin, and three C-glycosylated anthrones characterized as 8-O-methy-7-hydroxyaloin A/B, aloin A/B and aloin-6’-O-acetate A/B were isolated. The latex and isolated compounds exhibited in vitro antibacterial activity against the tested pathogens. In some cases the activity of the isolated compounds (MIC = 10 μg/mL) was comparable with that of the standard drug ciprofloxacin, particularly against some of the Gram-negative bacterial strains tested. However, their activity towards the fungal pathogens tested was relatively weaker showing maximum activity against Candida albicans with MIC value of 400 μg/mL.ConclusionThe present findings can be used for further research aimed at the development of new antibacterial agents, and may also justify the ethnomedicinal claim of the plant for the treatment of infectious diseases.

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“…This suggests that this compound could be employed as an anti-malarial drug. Other phytochemicals, Aloin (16) reported in the latex of Aloe debrana leaves latex, inhibited infection by 78.3% at 100 mg/kg body weight and increased the survival time of mice infected with P. berghei [ 52 ].…”

Section: Resultsmentioning

confidence: 99%

“…The crude extract of the plants was employed in the majority of the studies (76%). Acanthus polystachyus [50,51], Aloe debrana [52,53], Combretum molle [54,55], Croton macrostachyus [56,57], Clerodendrum Myricoides [53,58] and Dodonaea angustifolia [53,59,60] are examples of plant species that have been studied by more than one author. Echinops kebericho, Artemisia abyssinica, Aloe megalacantha, Carica papaya, Combretum molle, Croton macrostachyus, Ajuga remota, and Dodonaea angustifolia are some of the plant species listed in Table 2 that have anti-malarial activity, which supports the traditional uses indicated in Table 1.…”

Section: Scientific Studies Into the Anti-malarial Activity Of Ethiop...mentioning

confidence: 99%

Medicinal plants used in traditional treatment of malaria in Ethiopia: a review of ethnomedicine, anti-malarial and toxicity studies

Nigussie

Wale

2022

Malar J

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Background Malaria is extremely common in Ethiopia, and it is one of the country's most serious public health and economic problems. Traditional medicines have long been utilized in Ethiopia by people of various ethnic groups. As a result, the goal of this study is to record the use of Ethiopian medicinal herbs that have been used to treat malaria. Also, a critical review of the literature on the therapeutic properties of these and other Ethiopian medicinal plants that have been tested against Plasmodium spp. parasites was conducted with the goal of highlighting neglected studies and fostering further research in this area. Methods A comprehensive literature search was performed in Scopus, Web of Science Core Collection, PubMed, Science Direct, Google Scholar, and Scientific Electronic Library Online (SciELO) from August 2021 to October 2021. The study databases included original articles published in peer reviewed journals covering anti-malarial plants, dated until October 2021. Results The review looked at 51 plant species (28 families) that have been used to treat malaria in Ethiopia. The most often used ethnobotanical plant species for the treatment of malaria were Allium sativum, Croton macrostachyus, Carica papaya, and Lepidium sativum. Leaves were used more frequently as a therapeutic preparation than other parts. Plant extracts were found to have very good, good, and moderate anti-malarial activity in mice with rodent Plasmodium species. The most active species were Ajuga remota and Capsicum frufescens, which suppressed parasitaemia by 77.34% and 72.65%, respectively, at an oral dose of 100 mg/kg and an LD50 of above 2000 mg/kg. The compound Aloinoside reported from Aloe macrocarpa leave latex was the most potent; it suppressed parasitaemia by 100% at 400 mg/kg oral dose of Plasmodium berghei infected mice, and its LD50 was above 2000 mg/kg. Toxicity was shown to be safe in 84% of the plant extracts. Conclusion In Ethiopia, medicinal plants have a significant part in reducing the severity of malaria due to their widespread use. As a result, more studies are needed to identify and develop effective novel drugs that could be employed in broader malaria eradication efforts.

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Antimalarial Anthrone and Chromone from the Leaf Latex of <i>Aloe debrana</i> Chrstian

Cited by 12 publications

References 14 publications

Evaluation of in vitro and in vivo Antiplasmodial Activity of the Leaf Latex of Aloe Weloensis (Aloaceae)

Evaluation of in vitro and in vivo Antiplasmodial Activity of the Leaf Latex of Aloe Weloensis (Aloaceae)

Structural elucidation of some antimicrobial constituents from the leaf latex of Aloe trigonantha L.C. Leach

Medicinal plants used in traditional treatment of malaria in Ethiopia: a review of ethnomedicine, anti-malarial and toxicity studies

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