Antimalarial activity of &lt;i&gt;Mammea Africana&lt;/i&gt;

Okokon, Jude E.; Udokpoh, Aniekan E.; Essiet, Grace Akanimo

doi:10.4314/ajtcam.v3i4.31176

Cited by 10 publications

(5 citation statements)

References 12 publications

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“…All animals belonging to groups 2-5 were immunosuppresed with an intraperitoneal stat dose of 100 mg/kg cyclophosphamide[ 11 ], followed by a booster dose of 50 mg/kg on day 8. Malaria parasite was inoculated into the rats by intraperitoneal injection of approximately 1×10 6 parasites[ 12 ] on day 12. Animals that were treated with lamivudine received 20 mg/kg daily for 21 days while those that received artesunate were treated with 10 mg/kg of artesunate starting from day 15 of the study.…”

Section: Methodsmentioning

confidence: 99%

Histopathological effects of sub-chronic lamivudine-artesunate co-administration on the liver of diseased adult Wistar rats

Olurishe¹,

Kwanashie²,

Anuka³

et al. 2011

North Am J Med Sci

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Background:Lamivudine and artesunate are sometimes co administered in HIV-malaria co morbidity. Both drugs are used concurrently in presumptive malaria treatment and simultaneous HIV post exposure prophylaxis.Aim:The aim of this study was to investigate the effect of lamivudine-artesunate co administration on the histology of the liver of diseased adult Wistar rats.Materials and Methods:Five groups of rats of both sexes were used for the study and placed on feed and water ad libitum. Disease state consisted of immunosuppression with cyclophosphamide, and infection with Plasmodium berghei. Group 1 animals served as vehicle control, while group 2 were the diseased controls. Group 3 animals received 20 mg/kg lamivudine for three weeks, while group 4 similarly received 20 mg/kg Lamivudine but also received 10 mg/kg artesunate from day 12. Animals in group 5 received 10 mg/kg artesunate from day 12. All drugs were administered intraperitoneally. The animals were treated for twenty-one days, at the end of which they were sacrificed and their livers fixed in 10% formalin for histological studies.Result:Results from the study show the presence of regions of focal necrosis and perivascular cuffing with animals that received artesunate. Hemosiderosis was a common feature in all the parasitized groups, while fatty degeneration was observed in the group that received artesunate alone.Conclusion:Concurrent lamivudine-artesunate administration resulted in some histopathological changes in the liver. This study suggests there may be considerable histological changes with repeated occurrence of malaria and immunosuppression that may warrant intermittent lamivudine-artesunate administration, and may require evaluation as well as monitoring of liver function during such therapeutic interventions.

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Section: Methodsmentioning

confidence: 99%

Histopathological effects of sub-chronic lamivudine-artesunate co-administration on the liver of diseased adult Wistar rats

Olurishe¹,

Kwanashie²,

Anuka³

et al. 2011

North Am J Med Sci

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“…Ouahouo et al (2004) reported cytotoxic coumarins with anti-microbial activity against Staphylococcus aureus from the plant stembark. The stembark has been reported to have anti-plasmodial (Okokon et al 2006), cardioprotective (Okokon and Antia,2007), anti-diabetic, hypolipidaemic , vasorelaxant (Dongmo et al 2007), antihypertensive (Nguelefack-Mbuyo et al 2008), antiinflammatory, analgesic (Okokon et al 2009), antioxidant (Nguelefack-Mbuyo et al 2010), antidiarrheal, anti-ulcer (Okokon et al 2010, immunomodulatory, anti-lesihmanial (Okokon et al 2012), depressant and anti-convulsant (Okokon and Davis, 2014) as well as nephroprotective (Okokon and Bawo, 2014) and hepatoprotective (Okokon et al 2016) activities. The stembark has been reported to have 5,-7dihydroxy-8-(12-methyl-butryl)-4-N-pentylcoumarins (Carpenter et al 1970(Carpenter et al , 1971Crichton and Waterman, 1978), 4-phenyl and 4-alkylcoumarins (Games, 1972), mesuxanthone B (Carpenter et al 1971).…”

Section: Mammeamentioning

confidence: 99%

Inhibitory Effect of Mammea africana on Alpha-Amylase and Alpha-Glucosidase Enzymes of Rats

Ebong¹,

Okokon

Idakwoji³

2022

BIOMEDNATPROCH

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Mammea africana Sabine (Guttiferae), a medicinal plant used traditionally in the treatment of diseases including diabetes was evaluated for effect on alpha-amylase and alpha-glucosidase enzymes in vivo. The stembark extract (30, 60 and 90 mg/kg) of M. africana were investigated in vivo for inhibitory effect on alpha-amylase and alpha-glucosidase enzymes using starch, sucrose and maltose as substrates. Acarbose was used as reference drug. The stembark extract caused significant (p<0.05) reduction in blood glucose levels of treated rats with the various substrates used. The results suggest that the stembark extract of M. africana have the potentials to inhibit alpha-amylase and alpha-glucosidase in rats.

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“…Ouahouo et al, [6] reported "cytotoxic coumarins with anti-microbial activity against Staphylococcus aureus from the plant stembark". Additionally, anti-plasmodial [7], cardioprotective [8], anti-diabetic, hypolipidaemic [9,10], vasorelaxant [11] (Dongmo et al,2007), anti-hypertensive [12], anti inflammatory, analgesic [13], antioxidant [14], anti-diarrheal, anti-ulcer [15], immunomodulatory, antilesihmanial [5], depressant and anti-convulsant [16] as well as nephroprotective [17] and hepatoprotective [18],in vivo alpha amylase and alpha glucosidase inhibitory [19] activities. The stembark has been reported to have 5,-7dihydroxy-8-(12-methyl-butryl) -4 -Npentylcoumarins and mesuxanthone B [20][21][22], 4-phenyl and 4-alkylcoumarins [23].…”

Section: Introductionmentioning

confidence: 99%

Genotoxicity and Cytotoxicity Activities of Stembark Extract of Mammea africana

Okokon,

Edet,

Iyanyi

et al. 2024

AJBGMB

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Mammea africana, a medicinal plant, used in ethnomedicine for the treatment of malaria, diabetes, poisoning and inflammatory diseases was investigated for cytotoxic and genotoxic effects on the root meristem cells of Allium cepa. Onion bulbs were exposed to 2.5 mg/mL, 5mg/mL, and 10 mg/mL concentrations of the stembark extract for macroscopic and microscopic analysis. Tap water was used as a negative control and Methotrexate (0.1 mg/mL) as a positive control. There was statistically significant (p< 0.05) inhibition of root growth depending on concentration by the extract when compared with the negative control group. All the tested concentrations of the extract were observed to have cytotoxic effect on cell division in A. cepa. When compared to the control group, the extract-induced chromosomal abnormalities and micronuclei (MNC) forms in A. cepa root tip cells were substantial (p<0.05). Further inducing cell death, ghost cells, membrane damage, and binucleated cells was the extract treatment. These findings imply that the phytochemical components of Mammea africana root extract exert their cytotoxic and genotoxic actions on A. cepa.

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Antimalarial activity of <i>Mammea Africana</i>

Cited by 10 publications

References 12 publications

Histopathological effects of sub-chronic lamivudine-artesunate co-administration on the liver of diseased adult Wistar rats

Histopathological effects of sub-chronic lamivudine-artesunate co-administration on the liver of diseased adult Wistar rats

Inhibitory Effect of Mammea africana on Alpha-Amylase and Alpha-Glucosidase Enzymes of Rats

Genotoxicity and Cytotoxicity Activities of Stembark Extract of Mammea africana

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