Antimalaria activity of ethanolic extract of Tetrapleura tetraptera fruit

Okokon, Jude E.; Udokpoh, Aniekan E.; Antia, Bassey S.

doi:10.1016/j.jep.2006.12.030

Cited by 25 publications

(13 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…People also use this plant around food crops to protect them against pests. The selective antiplasmodial activity of Tetrapleura tetraptera bark observed here is consistent with the reported antiplasmodial activity of Tetrapleura tetraptera fruit in experimental mice [26]. These fruits contain many compounds with antiplasmodial activity, including triterpeniods and flavonoids [27,28].…”

Section: Resultssupporting

confidence: 90%

In vitro antiplasmodial activity of crude extracts of Tetrapleura tetraptera and Copaifera religiosa

et al. 2011

View full text Add to dashboard Cite

BackgroundMalaria remains a major public health problem, especially in tropical and subtropical regions because of the emergence and widespread of antimalarial drug resistance. Traditional medicine represents one potential source of new treatments. Here, we investigated the in vitro antiplasmodial activity of bark extracts from two Fabaceae species (Tetrapleura tertaptera and Copaifera religiosa) traditionally used to treat malaria symptoms in Haut-Ogooué province, Gabon.FindingsThe antiplasmodial activity of dichloromethane and methanolic extracts was tested on P. falciparum strains FCB (chloroquine-resistant) and 3D7 (chloroquine-sensitive) and on fresh clinical isolates, using the DELI method. Host cell toxicity was analyzed on MRC-5 human diploid embryonic lung cells using the MTT test.The dichloromethane extracts of the two plants had interesting activity (IC50 between 8.5 ± 4.7 and 13.4 ± 3.6 μg/ml). The methanolic extract of Tetrapleura tetraptera was less active (IC50 around 30 μg/ml) and the methanolic extract of Copaifera religiosa was inactive. The selectivity index (toxicity/antiplasmodial activity) of the dichloromethane extract of Tetrapleura tetraptera was high (around 7), while the dichloromethane extract of Copaifera religiosa had the lowest selectivity (0.6). The mean IC50 values for field isolates were less than 1.5 μg/ml for dichloromethane extracts of both plants, while methanolic extracts of Tetrapleura tetraptera showed interesting activity (IC50 = 13.1 μg/ml). The methanolic extract of Copaifera religiosa was also inactive on field isolates.ConclusionsDichloromethane extracts of Tetrapleura tetraptera and Copaifera religiosa, two plants used to treat malaria in Gabon, had interesting antiplasmodial activity in vitro. These data provide a scientific rationale for the traditional use of these plants against malaria symptoms. Bioactivity-guided phytochemical analyses are underway to identify the active compounds.

show abstract

Section: Resultssupporting

confidence: 90%

In vitro antiplasmodial activity of crude extracts of Tetrapleura tetraptera and Copaifera religiosa

et al. 2011

View full text Add to dashboard Cite

show abstract

“…The aqueous extract Tetrapleura tetraptera fruit also demonstrated interesting activity against Trypanosoma b. brucei and Trypanosoma cruzi with IC 50 values in the range of 6-9 g/ml with appreciable selectivity. Although this extract was found to be inactive in the present study against Plasmodium falciparum, a 70% ethanol extract from the same plant part was reported to produce 76.3% reduction in parasitaemia in mice infected with Plasmodium berghei at a high oral dose of 900 mg/kg bodyweight (Okokon et al, 2007). The stem bark extracts of Musanga cecropioides and Scorodophloeus zenkeri showed activity against Trypanosoma b. brucei and Leishmania infantum with IC 50 values in the range of 6-10 g/ml and with appreciable selectivity.…”

Section: Resultscontrasting

confidence: 50%

In vitro antiprotozoal and cytotoxic activity of 33 ethonopharmacologically selected medicinal plants from Democratic Republic of Congo

Muganza

Fruth

Lami

et al. 2012

Journal of Ethnopharmacology

View full text Add to dashboard Cite

“…They are: Cylicodiscus gabunensis (Okokon et al, 2006b), Uvaria chamae and Hippocratea africana (Okokon et al, 2006a), Enantia chlorantha and Cymbopogon giganteus (Agbaje and Onabanjo, 1991;Kimbi and Fagbenro-Beyioku, 1996), Cymbopogon citratus and Ocimum gratissimum (Tchoumbougnang et al, 2005), Cassia singueana (Adzu et al, 2003), Stachytarpheta cayennensis (Okokon et al, 2008), Striga hermonthica and Tapinanthus sessilifolius (Okpako and Ajaiyeoba, 2004), Tetrapleura tetraptera (Okokon et al, 2007b), Setaria megaphylla (Okokon et al, 2007c), Phyllanthus amarus (Dapper et al, 2007), Homalium letestui (Okokon et al, 2006c) and the plant formula 'Agbo-Iba' shown to protect mice against Plasmodium yoelii nigeriensis infection; the herbs used in this formula were decocted for 3 h and then administered to mice orally to evaluate the prophylactic and curative activities. Although the 'Agbo-Iba' formula was prophylactic and had no apparent significant side effects in mice, the formula had no curative activity against established infection (Nwabuisi, 2002).…”

Section: Scientific Authentication Of Antimalarial Activities Of Nigementioning

confidence: 99%

Potential antimalarials from Nigerian plants: A review

Adebayo

Krettli

2011

Journal of Ethnopharmacology

223

162

View full text Add to dashboard Cite

Malaria, caused by parasites of the genus Plasmodium, is one of the leading infectious diseases in many tropical regions, including Nigeria, a West African country where transmission occurs all year round. Many of the inhabitants use plants as remedies against fever and other symptoms of acute malaria, as reported herein. Some of these plants have their antimalarial efficacies scientifically demonstrated and the active compounds isolated with their probable mechanisms of action studied. Medicinal plants are used to treat diseases also where the biodiversity of plants occur in parallel with endemic transmission of malaria. This review focuses on medicinal plants which are used to treat malaria in Nigeria, and on antimalarial testing of extracts and purified compounds from plants. Some show intense activity against malaria parasites in vitro and in experimentally infected mice. The search for new drugs based on plants is important due to the emergence and widespread of chloroquine-resistant and multiple drug-resistant malaria parasites, which require the development of new antimalarials. An acquaintance with antimalarial plants may be a springboard for new phytotherapies that could be affordable to treat malaria, especially among the less privileged native people living in endemic areas of the tropics, mostly at risk of this devastating disease.

show abstract

Antimalaria activity of ethanolic extract of Tetrapleura tetraptera fruit

Cited by 25 publications

References 16 publications

In vitro antiplasmodial activity of crude extracts of Tetrapleura tetraptera and Copaifera religiosa

In vitro antiplasmodial activity of crude extracts of Tetrapleura tetraptera and Copaifera religiosa

In vitro antiprotozoal and cytotoxic activity of 33 ethonopharmacologically selected medicinal plants from Democratic Republic of Congo

Potential antimalarials from Nigerian plants: A review

Contact Info

Product

Resources

About