2014
DOI: 10.1186/1678-9199-20-50
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Abstract: BackgroundAmong the tropical parasitic diseases, those caused by protozoans are considered a challenge to public health, being represented by leishmaniasis and Chagas disease. In view of the low effectiveness and toxicity of the current therapy, animal venoms such as amphibian secretions have been used as a promising source of new drug prototypes. The present work aimed to achieve bioguided fractionation of metabolites present in a cutaneous secretion of the caecilian Siphonops annulatus (Amphibia: Gymnophiona… Show more

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Cited by 9 publications
(30 citation statements)
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References 23 publications
(30 reference statements)
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“…There are only few reports on bioactive properties of caecilian skin secretion till now. Antileishmanial and antitrypanosomal properties of the skin secretion of S. annulatus have been reported (Pinto, Antoniazzi, Jared, & Tempone, 2014). Schwartz, Schwartz, Sebben, and Mende (1997) studied the hemolytic and cardiotoxic properties of Siphonops paulensis skin secretion.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…There are only few reports on bioactive properties of caecilian skin secretion till now. Antileishmanial and antitrypanosomal properties of the skin secretion of S. annulatus have been reported (Pinto, Antoniazzi, Jared, & Tempone, 2014). Schwartz, Schwartz, Sebben, and Mende (1997) studied the hemolytic and cardiotoxic properties of Siphonops paulensis skin secretion.…”
Section: Discussionmentioning
confidence: 99%
“…A bioactive compound “siphonopsina” occurs in the caecilian S. annulatus from South America (Sawaya, ). Cytotoxic activity of the cutaneous secretion of S. annulatus against mammalian cells is known; antileishmanial and antitrypanosomal activities have also been reported (Pinto et al, ). The cardiotoxic and hemolytic properties of skin secretion of another North American caecilian S. paulensis have also been reported (Schwartz et al, ).…”
Section: Discussionmentioning
confidence: 99%
“…Cell viability was determined by resazurin assay as above described. Same conditions were applied to determine the CC 50 of the standard drug benznidazole, which was tested in a range concentration between 200 and 1.56 μg/mL [ 21 ]. DMSO was used to dissolve the compounds and was included in the microplate at 0.5% (v/v) to avoid toxicity.…”
Section: Methodsmentioning
confidence: 99%
“…The minimal mitochondrial membrane potential was obtained by treatment of trypomastigotes with 10 μM FCCP, a known mitochondrial uncoupler. Trypomastigotes were washed twice with PBS before fluorescence reading at λex = 540 nm and λex = 595 nm [ 21 ].…”
Section: Methodsmentioning
confidence: 99%
“…There are only a few reports on bioactive properties of caecilian skin secretion till now. Bioactive properties of the skin secretion of a caecilian amphibian Siphonops annulatus have been reported ( Pinto et al, 2014 ). Schwartz et al (1997) studied the haemolytic and cardiotoxic properties of the skin secretions of another caecilian – Siphonops paulensis .…”
Section: Discussionmentioning
confidence: 99%