Antiinflammatory effects of l-carnitine supplementation (1000 mg/d) in coronary artery disease patients

Lee, Bor‐Jen; Lin, Jun-Shuo; Lin, Yi-Chin; Lin, Ping-Ting

doi:10.1016/j.nut.2014.10.001

Cited by 75 publications

(60 citation statements)

References 36 publications

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“…In a similar study by Lee et al on 20 CAD patients with high CRP, showed significant decrease in CRP after LC treatment. 7 They also demonstrated decrease in other inflammatory markers like IL-6, TNF-α also with LC treatment.…”

Section: Resultsmentioning

confidence: 84%

Effect of L-carnitine supplementation on inflammatory marker of coronary artery disease

2017

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Background: L-carnitine (LC) might have the potential to control inflammation by reduction of major inflammatory cytokines, including CRP. Therefore, this study was planned to investigate the effect of LC supplementation on CRP levels in CAD patients.Methods: 50 subjects comprised placebo group who received standard line of treatment for coronary artery disease while other 50 subjects comprised LC group who received 1000 mg of LC daily apart from standard treatment for 12 weeks. CRP levels were measured at baseline and again after 12 weeks of treatment in all subjects.Results: The participants in the LC group had significantly lower levels of CRP after 12 weeks of supplementation with LC, than at baseline (p<0.01).Conclusions: We suggest that LC supplementation, due to its antioxidant effects, have potential utility to reduce inflammation in CAD.

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Section: Resultsmentioning

confidence: 84%

Effect of L-carnitine supplementation on inflammatory marker of coronary artery disease

2017

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“…In contrast, some studies disclosed a 14% decrease in IL-6 levels after supplementation with Q10 150 mg/d, and no significant change in hs-CRP levels (22). Previous studies also showed that IL-6 and CRP levels decreased significantly after LC supplementation (1000 mg/d) in patients with coronary artery disease (21). These results can possibly be explained by the synergistic effect of supplementation with Q10 plus LC on decreasing the inflammatory markers.…”

Section: The Effect Of Q10 Plus Lc Supplementationmentioning

confidence: 94%

“…The participants in the supplement group (group B) received two supplements: LC 1200 mg (produced by Karen Company, Iran) and Q10 150 mg (produced by LYNAE Company, U.S.). It is noteworthy that the appropriate doses of supplements were derived from a previous study (21,25). The participants in the TLC diet and supplement group (group C) received TLC diet and two supplements, namely LC 1200 mg and Q10 150 mg.…”

Section: Interventionmentioning

confidence: 99%

“…There are conflicting research results about the effects of Q10 and LC on inflammatory markers (21)(22)(23), lipid profiles (24,25), and LVEF (26,27). Although coenzyme Q10 supplementation has been found to affect inflammatory markers in healthy subjects, few clinical studies have investigated the relation between coenzyme Q10 and inflammation in patients with MI.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Therapeutic Lifestyle Change Diet and Q10 Plus L-Carnitine Supplementation on Inflammatory Biomarkers of In-Stent Restenosis, Lipid Profile, and Left Ventricular Ejection Fraction in Myocardial Infarction: A Randomized Clinical Trial

Sharifi

Eftekhari

Ostovan

et al. 2017

Iran Red Crescent Med J

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Background: Following Myocardial Infarction (MI) and percutaneous coronary intervention (PCI), the modification of cardiovascular risk factors and inflammation can improve MI progression and PCI outcomes. Up to now, no certain conclusions have been drawn regarding the effect of therapeutic lifestyle change (TLC) diet and a combination of Q10 plus L-carnitine (LC) supplementation on inflammatory biomarkers of In-Stent Restenosis (ISR), lipid profile, and Left ventricular ejection fraction (LVEF).Objectives: This study aimed to evaluate the effects of TLC diet and Q10 plus LC supplementation on inflammatory biomarkers of ISR, lipid profile, and LVEF following MI and PCI.Methods: This single-blind randomized controlled trial was conducted on 128 subjects. After randomization for treatment allocation, the subjects were divided into the study groups through block randomization. The MI patients were admitted to 2 hospitals, namely Al-Zahra and Kowsar (Shiraz, Iran), between April 2015 and May 2016. The patients were divided into 4 groups receiving TLC diet (A), oral Q10 150 mg/d and LC 1200 mg/d (B), a combination of LC plus Q10 and TLC diet (C), and the routine care (D). This study evaluated Interleukin-6 (IL-6) and high sensitive C-reactive protein (hs-CRP) as inflammatory biomarkers of ISR, lipid profile, and LVEF in 128 patients with MI undergoing PCI before and 3 months after the intervention. Results:The results showed a significant decrease in hs-CRP in groups B (11.8 ± 4.3 to 2.0 ± 1 mg/L) and C (11.7±3.9 to 1.3±1.1 mg/L) (P < 0.0001 and P < 0.0001, respectively), but not in group A. Also, a significant reduction was found in IL-6 in groups A (38.0 ± 15 to 9.4 ± 2 pg/mL), B (34.6 ± 12 to 5.1 ± 2.4 pg/mL), and C (33.7 ± 12 to 4.8 ± 2.1 pg/mL) (P < 0.0001, P < 0.0001, and P < 0.0001, respectively). Additionally, LDL and total cholesterol, but not TG, levels significantly decreased in groups A (150 ± 17 to 80 ± 13 mg/dL), B (148 ± 15 to 77.2 ± 14 mg/dL), and C (142 ± 11 to 64.8 ± 10 mg/dL) (P < 0.0001, P < 0.001, and P < 0.0001, respectively). Nevertheless, only group C showed a significant improvement in LVEF (45.1 ± 8 to 53.6 ± 8) (P < 0.027).Conclusions: An adjuvant therapy with TLC diet and supplementation with Q10 and LC seems to be required for secondary prevention following MI and PCI. TLC diet and Q10 plus LC appeared to be effective in inflammatory biomarkers of ISR as well as LDL reduction.

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“…Karnitin (hidroksi N trimetil aminobütirik asit) hayvansal kaynaklı besinlerin çoğunda bulunmaktadır ancak bitkisel kaynaklı besinlerde sınırlıdır (67). Karnitin ve inflamasyon arasındaki bağlantıya dair mekanizmalar net olmamasına karşın, karnitinin fazla ve toksik olan açil grupların vücuttan uzaklaştırılmasında rol alması ve serbest radikalleri süpürücü etkisinin olması; anti-inflamatuvar aktivitesinin altında yatan mekanizmalar olabileceği düşünülmektedir (68,69).…”

Section: Karnitinunclassified

Kronik Böbrek Hastalığında Renal İnflamasyon ve Bazı Güncel Diyet Bileşenleri İlişkisi

Öztürk¹,

Nergiz-Unal²

2018

Turk Neph Dial Transpl

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ÖZKronik böbrek hastalığı, glomerüler filtrasyonun azalmasıyla böbrekte sıvı-solüt dengesinin düzenlen-mesi ve metabolik-endokrin fonksiyonlarda kronik ve ilerleyici bozulma hali olarak tanımlanabilir. Kronik böbrek hastalığı gelişiminde rol alan inflamasyon, kronik böbrek hastalığının sonucu olarak da ortaya çıkabilmekte ve KBH varlığına bağlı mortalite artışının en önemli nedenlerinden biri olarak kabul edilmektedir. İnflamasyon ve diyet etkileşimi ile ilgili yapılan güncel araştırmalar çoklu doymamış yağ asitleri, D vitamini, E vitamini gibi besin ögeleri ile karnitin, lipoik asit, flavanoidler, probiyotikler ve prebiyotikler gibi diğer diyet bileşenlerinin renal inflamasyon sürecindeki olumlu etkilerine işaret etmektedir. Derlemede, olası anti-inflamatuvar bazı diyet bileşenlerinin kronik böbrek hastalığı ile ilişkili inflamasyon üzerine etkileri incelenmiştir. ANAHTAR SÖZCÜKLER: Kronik böbrek hastalığı, Beslenme, İnflamasyon, Diyet ABSTRACTChronic kidney disease can be defined as chronic and progressive deterioration of the regulation of fluid-solute balance and metabolic-endocrine functions of the kidney due to diminishing glomerular filtration. Inflammation in renal disease can develop as a cause or an outcome, and it has been reported in recent studies that inflammation is among the most important causes of disease-related mortality. Investigations on inflammation and diet interactions have shown that the effects of nutrients such as polyunsaturated fatty acids, vitamin D, vitamin E and other dietary components such as carnitine, lipoic acid, flavanoids, probiotics and prebiotics may have positive effects on the renal inflammation process. In this review, the potential anti-inflammatory effects of some current dietary components in chronic kidney disease were studied.

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Antiinflammatory effects of l-carnitine supplementation (1000 mg/d) in coronary artery disease patients

Cited by 75 publications

References 36 publications

Effect of L-carnitine supplementation on inflammatory marker of coronary artery disease

Effect of L-carnitine supplementation on inflammatory marker of coronary artery disease

Effects of Therapeutic Lifestyle Change Diet and Q10 Plus L-Carnitine Supplementation on Inflammatory Biomarkers of In-Stent Restenosis, Lipid Profile, and Left Ventricular Ejection Fraction in Myocardial Infarction: A Randomized Clinical Trial

Kronik Böbrek Hastalığında Renal İnflamasyon ve Bazı Güncel Diyet Bileşenleri İlişkisi

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