Antiinflammatory and analgesic activities of Zizyphus lotus root barks

Borgi, Wahida; Ghédira, Kamel; Chouchane, Nabil

doi:10.1016/j.fitote.2006.09.010

Cited by 83 publications

(53 citation statements)

References 6 publications

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“…Previous studies reported that, plants are rich in alkaloids triterpenoids, flavanoids and saponins which showed present antiinflammatory activity (Haihua Shu et al, 2006;Theophile et al, 2006;Borgi et al, 2007) Preliminary phytochemical analysis performed in this study shows the present of triterpenoids, saponins, polyphenols, steroids, tannins and flavanoids in the seed extract of E. agallocha. The anti-inflammatory activity action of triterpenoids has been reported by many researchers (Vazquez et al, 1996;Suh et al, 1998';Huss et al, 2002).…”

Section: Discussionsupporting

confidence: 51%

Evaluation of anti-inflammatory and analgesic effects on the extracts of different parts of Excoecaria agallocha L.

Babuselvam¹

2012

J. App. Pharm. Sci.

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Scientific evaluated that, anti-inflammatory and analgesic activity of ethanol with water in the ratio of 3:1 extracts were obtained from different parts viz., leaves, seeds and latex of Excoecaria agallocha. The latex was sequentially soxhlated with petroleum ether and methanol dried latex in anti-inflammatory processes and analgesic activity in two concentrations (250 mg/kg and 500 mg/kg). Preliminary phytochemical analysis showed that, presence of alkaloids, flavanoids, saponins were found maximum in the seed extract. Acute inflammatory studies showed that, latex, leaves and seed extracts of both concentration of chosen plant produced significant inhibition of carrageenin induced rat paw edema at 3 rd hour (p<0.005) as compared to the control causing 63.15%, 62.15% and 69.69% respectively. In addition that, the seed extract at the concentration of 500 mg/kg showed maximum inhibition at 57.03% as compared to control in cotton pellet induced granuloma test. The analgesic activity of seed extract at the dose of 500 mg/kg. caused significant inhibitions in the acetic acid induced writhing. Moreover, the tail immersion model, seed extract at the concentration of 500 mg/kg. possess an maximum activity (80.29%) as compared to control.

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Section: Discussionsupporting

confidence: 51%

Evaluation of anti-inflammatory and analgesic effects on the extracts of different parts of Excoecaria agallocha L.

Babuselvam¹

2012

J. App. Pharm. Sci.

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“…Carrageenan is used as a noxious agent inducing a severe inflammatory reaction (Borgi et al 2007). The crude extract and its fractions F1 and F2 produced reduction of the oedema throughout the entire period of observation in a dose-related manner with a maximum at 3 h with, respectively, 52.11%, 50.72 % and 56.06% at the dose of 50 mg/kg and with 55.35%, 52.18% and 62.86%, respectively, at 100 mg/kg.…”

Section: Carrageenan Paw Oedema Testmentioning

confidence: 99%

In vitroimmunomodulatory activity andin vivoanti-inflammatory and analgesic potential with gastroprotective effect of the Mediterranean red algaLaurencia obtusa

Lajili

Deghrigue

Amor

et al. 2016

Pharmaceutical Biology

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Context: Red algae have been recognized as a rich natural source of compounds possessing interesting biological and pharmacological activities. Objective: This work investigates anti-inflammatory, analgesic and gastroprotective activities of MeOH/ CH 2 Cl 2 crude extract and its fractions F1 (50% MeOH) and F2 (80% MeOH) from the whole alga plant Laurencia obtusa Hudson (Rhodomelaceae). Materials and methods: Anti-inflammatory activity was evaluated in vitro using cytometric bead array (CBA) technology to follow up the secretion of tumour necrosis factor alpha (TNF-a) in lipopolysaccharide activated THP-1 monocytic cells at doses of 10-250 lg/mL and in vivo using carrageenan-induced paw oedema in Wistar rats at doses of 25, 50, 100 and 200 mg/kg. Crude extract and fractions were tested at the doses of 25, 50, 100 and 200 mg/kg for peripheral and central analgesic activity by acetic acid-induced writhing test and hot-plate method, respectively, in Swiss albino mice. Gastroprotective activity was evaluated using HCl/ethanol-induced gastric ulcer test in rats at doses of 25, 50, 100 and 200 mg/kg. Results: Crude extract, F1 and F2 showed an interesting inhibition of TNF-a secretion with IC 50 values of 25, 52 and 24 lg/mL, respectively, and a significant anti-inflammatory activity in vivo (p < 0.01), 3 h after carrageenan injection, the oedema inhibition was 55.37%, 52.18% and 62.86%, respectively, at the dose of 100 mg/kg. Furthermore, they showed a significant peripheral analgesic activity with 53.79%, 55.92% and 57.37% (p < 0.01) of writhing inhibition, respectively. However, no significant activity was found in the hotplate test. An interesting gastroprotective effect was observed with crude extract and its fractions F1 and F2 with a gastric ulcer inhibition of 65.48%, 77.42% and 81.29%, respectively, at the dose of 50 mg/kg. Discussion and conclusion: These results suggest that L. obtusa might be used as a potential source of natural anti-inflammatory and analgesic agents with gastroprotective effect. ARTICLE HISTORY

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“…Cyclopeptides alkaloids [9][10][11] , dammarane saponins [12,13] , and a new flavonol glycoside [14] have been isolated from this plant. In addition, the anti -inflammatory, the analgesic, anti -ulcerogenic and the anti -spasmodic activities of this plant were demonstrated in rodents [15][16][17][18] . In the view of the traditional use and the chemical composition of Z. lotus, the present study was carried out to examine the possible antioxidant activity in -vitro of some secondary metabolites: polyphenols, flavonoids and tannins of Z. lotus roots.…”

Section: Introductionmentioning

confidence: 99%

Study on the antioxidant activities of root extracts of Zizyphus lotus from the western region of Algeria

Ghalem¹,

Merghache²,

Belarbi³

2014

Phcog J.

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Objective: To find a new natural source of antioxidant, the phenolic contents and antioxidant activities of some secondary metabolites extracted from roots of Ziziphus lotus were evaluated. Methods: The total polyphenol contents were determined spectrophotometrically. Pyrrocatechol, catechin and cyanidin equivalents were used for these parameters. The antioxidant activities of the extracts were determined by several in vitro systems of assays, namely DPPH radical scavenging activity method, b-Carotene Bleaching assay (BCB), Ferric Reducing Antioxidant Power assay (FRAP) and Total Antioxidant capacity test (TAC). Results: The quantitative estimation showed that the roots of Z. lotus were rich in polyphenols (20.09 mg PE/g DW) and proanthocyannidins (1.56%) and they contained a small amount of flavonoids (0.02 mg CE/g DW). The most fractions exhibited high antioxidant activities, and some even showed higher potency than the standard synthetic antioxidants in some instances. In DPPH assay, all extracts had shown significant inhibition (58.535 -94.730% at 1 mg/mL). In addition, the IC 50 values ranged from 0.211 to 0.816 mg/mL, compared to 0.110, 0.214, 0.214 and 0.413 mg/mL for gallic acid, tannic acid, butylated-hydroxyanisol and ascorbic acid respectively. In (BCB) assay, the extracts showed strong inhibition (55.55 -100.00% at 1 mg/mL) and the IC 50 values ranging from 0.123 to 0.850 mg/mL compared to 0.433 mg/mL for gallic acid. A dose dependant curve was obtained for all extracts in the FRAP assay. However, the antioxidant potencies of ascorbic acid and extracts were comparable at low concentrations. The majority of extracts showed the highest value of antioxidant activity, based on TAC test (0.073 -0.398 mg ascorbic acid / mg extract). Conclusion: The results indicate that Z. lotus roots could be an important sources of natural antioxidants.

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Antiinflammatory and analgesic activities of Zizyphus lotus root barks

Cited by 83 publications

References 6 publications

Evaluation of anti-inflammatory and analgesic effects on the extracts of different parts of Excoecaria agallocha L.

Evaluation of anti-inflammatory and analgesic effects on the extracts of different parts of Excoecaria agallocha L.

In vitroimmunomodulatory activity andin vivoanti-inflammatory and analgesic potential with gastroprotective effect of the Mediterranean red algaLaurencia obtusa

Study on the antioxidant activities of root extracts of Zizyphus lotus from the western region of Algeria

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