Antiinflammatory Activity of Some Extracts from Plants used in the Traditional Medicine of North-African Countries

Abstract

Aqueous, ethanol and chloroform extracts from five plants were administered either topically (oedema induced by arachidonic acid in mouse ear) or i.p. (subplantar oedema induced by carrageenan in rats). Our results show that Anacyclus pyrethrum, Armeria alliacea, Asphodelus ramosus, Capparis spinosa and Rhaponticum acaule possess antiinflammatory activity, since at least one extract of each plant was active in one of the experimental models. The three extracts from Anacyclus pyrethrum showed significant activity in both experimental models, but the highest antiinflammatory activity was exhibited by the polar extracts of Armeria alliacea. The ethanol extract of the latter produced 100% inhibition of the inflammation induced by carrageenan and this inhibition was highly significant (p<0.001) with reference to values found in both active (indomethacin 3 mg/kg) and vehicle administered control groups.

Anti-inflammatory, Antinociceptive, and Antioxidant Activities of Methanol and Aqueous Extracts of Anacyclus pyrethrum Roots

“…COX catalyzes the conversion of arachidonic acid to prostaglandin ( Williams et al, 1999 ), leading to the activation and sensitization of peripheral nociceptors. Since the vast majority of studies of alkamides shows their peripheral antinociception effects ( de la Rosa-Lugo et al, 2017 ), on the basis of the Rimbau et al (1999) study and our current findings, we suggest that the peripheral anti-nociception activity of AEAPR and MEAPR may be due to their alkamides.…”

Quantitative transdermal behavior of pellitorine from Anacyclus pyrethrum extract

“…This anti-inflammatory effect was confirmed in vitro with different AP extracts (Rimbau et al, 1996). In addition, pellitorine was demonstrated in vivo to have a strong tingling and saliva stimulating effect (Sharma et al, 2010).…”

A Comprehensive Review on the Medicinal Plants from the Genus Asphodelus

“…Root extracts of A. ramosus showed positive in vivo anti-inflammatory activity, confirming the traditional uses of the plant in inflammatory disorders [23]. …”

“…In particular, A. aestivus , A. fistulosus and A. microcarpus were reported to be used in dermatomucosal infections in various countries including Cyprus, Egypt, Libya, Palestine, and Spain [16,17,18,19,20]. A. microcarpus , A. ramosus and A. tenuifolius were generally indicted as anti-inflammatory agents specifically for the treatment of psoriasis, eczema, and rheumatism [21,22,23,24,25,26,27,28]. A. aestivus and A. tenuifolius are also used for ulcer treatment in Turkey, India, and Pakistan [26,27,28,29].…”