Antiinflammatory activity of extracts of Biophytum sensitivum in carrageenin‐induced rat paw oedema

Abstract

The antiinflammatory activity of aqueous and methanol extracts of aerial parts, an aqueous extract of roots as well as ultrafiltration fractions of a methanol extract of roots of Biophytum sensitivum were evaluated in the carrageenin induced rat paw oedema model. All the extracts except the methanol extract of aerial parts exhibited antiinflammatory activity, but inhibition of oedema was found to be maximum with aqueous extracts.

Ethnopharmacological survey of six medicinal plants from Mali, West-Africa

“…Methanolic extract has shown effect on COX-2 expression [ 6 ], and different types of polyphenolic compounds, some with effect on the COX-1/-2 system, have been isolated from B. sensitivum [ 7 - 10 ]. Different types of extracts from the plant have shown anti-inflammatory activity on the carrageenan-rat paw endema [ 11 ] and complement fixing polysaccharides from the plant have been reported [ 4 , 5 ]. The results above may explain the traditional use in treatment of malaria as the complement system is a part of the innate immune system and activating of the immune system can accelerate the body's immune response to malaria.…”

Wound Healing Plants in Mali, the Bamako Region. An Ethnobotanical Survey and Complement Fixation of Water Extracts from Selected Plants

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Biophytum sensitivum Chemical Constituents and Medicinal Properties: A Review

“…The methanolic extract of whole plant of B. sensitivum was reported to have significant anti-inflammatory activity at the dose of 100 and 200 mg/kg in the carrageenin-induced, histamine-induced and dextran-induced paw oedema model in the rats (Jachak et al, 1999). Anti-inflammatory activity of aqueous extracts of aerial parts and roots, methanol extract of aerial parts and ultrafiltration fractions of a methanol extract of roots of B. sensitivum were also evaluated in the carrageenin-induced rat paw edema.…”