Antihypertensive therapy increases natural immunity response in hypertensive patients

Fonseca, Henrique Andrade Rodrigues da; Fonseca, Francisco A.; Lins, Lívia Campos Amaral; Monteiro, Aílton Rocha; Bianco, Henrique Tria; Brandão, Sérgio Augusto Bueno; Póvoa, Rms; Juliano, Luiz; Neto, A. M. Figueiredo; Boschcov, Paulo; Gidlund, Magnus; Izar, Maria Cristina de Oliveira

doi:10.1016/j.lfs.2015.10.030

Cited by 14 publications

(15 citation statements)

References 30 publications

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“…Antihypertensives may also affect immune cells. Several blood pressure medications have been proposed to stimulate cells of the immune system, including B and T lymphocytes (Fonseca et al., 2015; Petrov, Fagard, & Lijnen, 2001). This would theoretically be beneficial for immunogenic cancers like melanoma, which rely on natural killer cells, dendritic cells, and T lymphocytes for immunosurveillance (Bernstein et al., 2018; Lakshmikanth et al., 2009).…”

Section: Introductionmentioning

confidence: 99%

Antihypertensives and melanoma: An updated review

Williams

Vincent

Rodriguez

et al. 2020

Pigment Cell Melanoma Res

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Antihypertensive medications are commonly prescribed and well-studied. Given the widespread use and potential side effects, various theories have been made about the relationship between antihypertensives and malignancy, including melanoma. This review describes the current understanding of the most commonly prescribed antihypertensives and their associations with melanoma. The literature demonstrates that diuretics, specifically hydrochlorothiazide and indapamide, may increase the risk of melanoma. While there is no evidence that antihypertensives have a role in melanoma prevention, non-selective β-blocker therapy has been associated with a decreased risk of disease progression and recurrence and may also improve outcomes in patients undergoing immunotherapy. In addition, experimental studies reveal that angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and calcium channel blockers have anti-tumor effects, meriting further study.

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Section: Introductionmentioning

confidence: 99%

Antihypertensives and melanoma: An updated review

Williams

Vincent

Rodriguez

et al. 2020

Pigment Cell Melanoma Res

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“…15,16 Este estudo também mostrou que AAC de IgM contra ApoB-D estavam associados à ED, corroborando com estudos anteriores. 6,17 Nossos achados sugerem que há uma eliminação de autoantígenos ApoB por anticorpos naturais, sugerindo que eles possam estar envolvidos em reparos vasculares após um processo de lesão, 18 entretanto, os efeitos da infecção por HIV da DMF podem ser atribuídos a um estágio distinto da doença e às diferentes terapias medicamentosas adotadas. 19 Estudos de coorte e meta-análise demonstraram que a EIMC é mais alta em pacientes infectados com HIV, em comparação com não infectados.…”

Section: Discussionunclassified

“…Estudos anteriores demonstraram que anticorpos contra um peptídeo específico (ApoB-D) podem ser considerados um marcador de ativação inflamatória. [5][6][7] Entretanto, não foi demonstrado que infecções crônicas podem modular os autoanticorpos (AAC) em autoantígenos, especialmente na condição de deficiência do sistema imune.…”

Section: Introductionunclassified

Pacientes Naïve Infectados por HIV Apresentam Disfunção Concomitante com Diminuição de Anticorpos Naturais contra Autoantígenos Derivados da Apolipoproteína B Definidos

Fonseca¹,

Gidlund²,

Sant’Anna³

et al. 2021

Arquivos Brasileiros De Cardiologia

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“…Our study is not without limitations. Given the timespan over which included studies were conducted, it was not reasonable to analyze patient-level data nor were we successful in obtaining study data (except for 1 article 73 ) where papers indicated a measure of glucose without necessary details (authors were either not contactable or no longer had data of interest). The design of included studies also did not enable an analysis of confounding by co-intervention, outside of those which were assigned at randomization.…”

Section: Discussionmentioning

confidence: 99%

Thiazide Diuretic–Induced Change in Fasting Plasma Glucose: a Meta-analysis of Randomized Clinical Trials

et al. 2020

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BACKGROUND: Prior meta-analyses measuring thiazideinduced glycemic change have demonstrated an increased risk of incident diabetes; however, this measure's definition has changed over time. AIM: To determine the magnitude of change in fasting plasma glucose (FPG) for thiazide diuretics. DATA SOURCES: A research librarian designed and conducted searches in Medline®, EMBASE, and EBM Reviews-Cochrane Central Register of Controlled Trials (inception through July 2018) and International Pharmaceutical Abstracts (inception to December 2014). STUDY SELECTION: Randomized, controlled trials comparing a thiazide or thiazide-like diuretic to any comparator reporting FPG were identified. Trials enrolling < 50 participants, those with a follow-up period of < 4 weeks, and conference abstracts were excluded. DATA EXTRACTION: Independent duplicate screening of citations and full-text articles, data extraction, and assessment of risk of bias was conducted. DATA SYNTHESIS: Ninety-five studies were included (N = 76,608 participants), with thiazides compared with placebo, beta-blockers, calcium channel blockers, reninangiotensin-aldosterone-system inhibitors, potassiumsparing diuretic, and others alone or in combination. Thiazide diuretics marginally increased FPG (weighted mean difference 0.20 mmol/L (95% CI 0.15-0.25); I 2 = 84%) (1 mmol/L = 18 mg/dL). Results did not change substantially when considering dose or duration, comparing thiazides with placebo or an active comparator, or using thiazides as monotherapy or combination therapy, even when combined with a potassium-correcting agent. CONCLUSION: Thiazide diuretics have a small and clinically unimportant impact on FPG.

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Antihypertensive therapy increases natural immunity response in hypertensive patients

Cited by 14 publications

References 30 publications

Antihypertensives and melanoma: An updated review

Antihypertensives and melanoma: An updated review

Pacientes Naïve Infectados por HIV Apresentam Disfunção Concomitante com Diminuição de Anticorpos Naturais contra Autoantígenos Derivados da Apolipoproteína B Definidos

Thiazide Diuretic–Induced Change in Fasting Plasma Glucose: a Meta-analysis of Randomized Clinical Trials

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