Antihypertensive effects of food-intake restriction in aortic coarctation hypertension

Jm, VanNess; Rm, Casto; Jm, Overton

doi:10.1097/00004872-199715110-00009

Cited by 21 publications

(7 citation statements)

References 37 publications

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“…In contrast, after metoprolol injection, these parameters were not affected (Loss et al, 2007 ). In accordance to another models of malnutrition studies (Herlihy et al, 1992 ; VanNess et al, 1997 ; de Belchior et al, 2012 ), these data indicate that low-protein diet disrupts cardiovascular regulation driven by baroreflex loops.…”

Section: The Influence Of Post-weaning Low-protein Diet On Cardiovascsupporting

confidence: 88%

The implication of protein malnutrition on cardiovascular control systems in rats

2015

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The malnutrition in early life is associated with metabolic changes and cardiovascular impairment in adulthood. Deficient protein intake-mediated hypertension has been observed in clinical and experimental studies. In rats, protein malnutrition also increases the blood pressure and enhances heart rate and sympathetic activity. In this review, we discuss the effects of post-weaning protein malnutrition on the resting mean arterial pressure and heart rate and their variabilities, cardiovascular reflexes sensitivity, cardiac autonomic balance, sympathetic and renin-angiotensin activities and neural plasticity during adult life. These insights reveal an interesting prospect on the autonomic modulation underlying the cardiovascular imbalance and provide relevant information on preventing cardiovascular diseases.

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Section: The Influence Of Post-weaning Low-protein Diet On Cardiovascsupporting

confidence: 88%

The implication of protein malnutrition on cardiovascular control systems in rats

2015

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“…Thus increased activation of NPYergic activity in the hypothalamus could contribute to sympathoinhibitory and hypotensive effects of reduced caloric intake. In fact, the central administration of a NPY antagonist D-NPY (27)(28)(29)(30)(31)(32)(33)(34)(35)(36) blunts the fall in blood pressure associated with CR (27).…”

Section: Discussionmentioning

confidence: 99%

“…hypertension; blood pressure; food restriction; ␤-myosin heavy chain A RELATIONSHIP BETWEEN DIET and blood pressure has been recognized for many years (15). Prolonged caloric restriction (CR) significantly lowers blood pressure in hypertensive humans, normotensive rats, and in many models of hypertension in rats (8,14,25,27,30). The autonomic nervous system appears to mediate this hypotensive effect and bradycardia of CR.…”

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confidence: 99%

Altered leptin signaling is sufficient, but not required, for hypotension associated with caloric restriction

Swoap

2001

American Journal of Physiology-Heart and Circulatory Physiology

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Caloric restriction of mammals leads to decreases in blood pressure and heart rate. Although relevant clinically, the mechanisms involved, in terms of hormones and signaling pathways invoked, are currently not known. Circumstantial evidence suggests that leptin signaling may be involved with the bradycardia and hypotension associated with caloric restriction. This hypothesis was specifically tested using leptin-deficient mice (ob/ob) or leptin-receptor rats (Koletsky). Ob/ob mice were hypertensive during the light cycle relative to littermate controls (108 +/- 2 vs. 100 +/- 2 mmHg, respectively). Both ob/ob mice and wild-type mice exhibited hypotension and bradycardia on initiation of a 50% caloric restriction regime, suggesting that the loss of leptin during caloric restriction is not required to explain the cardiovascular effects. Blood pressure in Koletsky rats did not drop in response to caloric restriction during the light cycle, whereas blood pressure in littermate control rats significantly dropped. These data suggest that at least two pathways are involved with cardiovascular effects of caloric restriction: one dependent on leptin signaling and the other independent of the leptin axis.

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“…Restriction of caloric intake has been known for many years to be an effective tool for lowering blood pressure in hypertensive humans, hypertensive rats, and even normotensive mice (8,18,27,35,40,39,42). Both leptin signaling and insulin signaling have been suggested as mediators of the hypotensive effect of caloric restriction (12,19).…”

mentioning

confidence: 99%

Dbh(-/-) mice are hypotensive, have altered circadian rhythms, and have abnormal responses to dieting and stress

Swoap¹,

Weinshenker²,

Palmiter³

et al. 2004

American Journal of Physiology-Regulatory, Integrative and Comp

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[Dbh(ϩ/Ϫ)] to examine the role of epinephrine (Epi) and norepinephrine (NE) in the maintenance of cardiovascular parameters during 7 days of caloric restriction and acute exposure to environmental stress. Cardiovascular parameters of the mice were monitored using blood pressure radiotelemeters at an ambient temperature of 29°C. Under normal conditions, Dbh(Ϫ/Ϫ) mice had a low heart rate, were severely hypotensive, and displayed an attenuated circadian blood pressure rhythm. Upon 50% caloric restriction, Dbh(ϩ/Ϫ) mice exhibited decreases in heart rate and mean blood pressure. However, the blood pressures of Dbh(Ϫ/Ϫ) mice did not fall significantly in response to caloric restriction, and the bradycardia associated with caloric restriction was attenuated in these mice. In response to an open-field test, the blood pressure and heart rate of Dbh(ϩ/Ϫ) mice increased substantially and rapidly, whereas Dbh(Ϫ/Ϫ) mice had blunted changes in blood pressures and no change in heart rate. These data suggest a primary role of Epi and NE in mediating the hypotension induced by dieting. Furthermore, Epi and NE play a smaller, but still significant, role in the bradycardia induced by caloric restriction. In contrast, Epi and NE are required for the tachycardia in an open field but are not required for the increase in blood pressure.hypertension; blood pressure; food restriction; sympathetic nervous system; radiotelemetry; dopamine ␤-hydroxylase-deficient mice

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Antihypertensive effects of food-intake restriction in aortic coarctation hypertension

Abstract: Food-intake restriction attenuates the rise in MAP which occurs after aortic coarctation significantly. The antihypertensive effect of food-intake restriction may be mediated via a reduction in sympathetic tone.

Cited by 21 publications

References 37 publications

The implication of protein malnutrition on cardiovascular control systems in rats

The implication of protein malnutrition on cardiovascular control systems in rats

Altered leptin signaling is sufficient, but not required, for hypotension associated with caloric restriction

Dbh(-/-) mice are hypotensive, have altered circadian rhythms, and have abnormal responses to dieting and stress

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