Antihyperglycemic and insulin secretory activity of Costus pictus leaf extract in streptozotocin induced diabetic rats and in in vitro pancreatic islet culture

Exploration of natural enzyme inhibitors with hypoglycemic potentials amongst Eucalyptus Spp. by in vitro assays

“…According to the literature, compounds with highest reducing ability have delocalized chemical bonds [56][57][58][59][60] . Prior research suggested a strong positive correlation (R 2 = 0.99) between phenolic content and antioxidative potential [12,18,58,59] . Polyphenols received wide attention because of their antioxidant properties which refers to their ability to prevent damage from ROS through radical scavenging or prevent the generation of these species by iron chelation [61] .…”

“…have been used in folk medicine for the treatment of ailments such as colds, fever, toothache, diarrhea and snake bites. Uses of Eucalyptus leaf hot decoctions as "herbal tea" have been recorded in Aboriginal, European and British Pharmacopeias for the traditional remedy of type DM [10][11][12][13][14][15][16][17][18][19][20][21] . A rich literature exists, reporting over 500 Eucalyptus species with different pharmacological actions [11][12][13][14][15][16][17][18][19][20][21][22] .…”

“…Uses of Eucalyptus leaf hot decoctions as "herbal tea" have been recorded in Aboriginal, European and British Pharmacopeias for the traditional remedy of type DM [10][11][12][13][14][15][16][17][18][19][20][21] . A rich literature exists, reporting over 500 Eucalyptus species with different pharmacological actions [11][12][13][14][15][16][17][18][19][20][21][22] . Hypoglycemic potentials of Eucalyptuses are documented, but the mechanistic actions need to be explored further [11][12][13][14][15][16][17][18][19][20][21] .…”

“…A rich literature exists, reporting over 500 Eucalyptus species with different pharmacological actions [11][12][13][14][15][16][17][18][19][20][21][22] . Hypoglycemic potentials of Eucalyptuses are documented, but the mechanistic actions need to be explored further [11][12][13][14][15][16][17][18][19][20][21] . Inhibiting the actions of carbohydrate hydrolyzing enzymes like α-amylase and α-glucosidase helps to reduce post-prandial (PP) hyperglycemia.…”

Antidiabetic effect of Merremia emarginata Burm. F. in streptozotocin induced diabetic rats

“…The observed increase in the level of plasma insulin indicates that M. emarginata stimulates insulin secretion from the remnant beta cells or from regenerated beta cells. In this context, a number of other plants have also been reported to exert hypoglycemic activity through insulin release stimulatory effect [33,34] . Decreased body weight observed in diabetic control rats in comparison to normal rats indicates that loss of body weight is a result of excessive breakdown of tissue proteins [35][36][37][38][39][40][41] .…”