Antihypercholesterolaemic effect of ginger rhizome (Zingiber officinale) in rats

ElRokh, El-Sayed M.; Yassin, Nemat A.; El‐Shenawy, Siham M.; Ibrahim, Bassant M. M.

doi:10.1007/s10787-010-0053-5

Cited by 62 publications

(47 citation statements)

References 23 publications

(24 reference statements)

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“…33 Mozaffari et al observed that daily intake of three grams of ginger for eight weeks in diabetic patient leads to a reduction in serum LDL-C level, but does not affect the levels of total cholesterol, TG and HDL-C. 24 The finding of the present study on the effect of ginger on serum cholesterol concentration is consistent with the results of many animal studies. 28,34 The reduction of cholesterol by ginger can be explained as follows: Ginger can induce cholesterol conversion to bile acids by increasing activity the cholesterol-7 -α-hydroxylase enzyme and ultimately lead to, decline serum cholesterol level. 33 Also, it has been reported that ginger compounds suppress the synthesis of cholesterol in the mice liver cells.…”

Section: Discussionmentioning

confidence: 99%

<p>Effect of Ginger Powder Supplementation in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial</p>

Rafie¹,

Hosseini²,

Hajiani³

et al. 2020

CEG

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Background: Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver disorders. The main causes of NAFLD are associated with insulin resistance, severe lipid metabolism disorders, oxidative stress and inflammation. Previous studies have reported that ginger has positive metabolic results. Aim: The aim of this study was to determine the effect of ginger powder supplement on lipid profiles, insulin resistance, liver enzymes, inflammatory cytokines and antioxidant status in patients with NAFLD. Methods: In this randomized clinical trial, 46 people with NAFLD were parted into two groups and subjected to the ginger or placebo capsules (3 capsules daily, each containing 500 mg of ginger or wheat flour) over 12 weeks. All patients received a diet with balanced energy and physical activity during the intervention period. Liver ultrasonography, anthropometric indices and biochemical parameters were measured before and after intervention. Results: No significant difference was found between the two groups in the baseline variables at the beginning of the study. At the end of the study, serum levels of alanine aminotransferase (ALT), total cholesterol, low-density lipoprotein (LDL-C), fasting blood glucose, and insulin resistance index (HOMA), C-reactive protein (hs-CRP), and fetuin-A in the group receiving a ginger supplement significantly decreased compared to placebo. However, there was no significant difference between the two groups in body weight, fasting insulin, HDL-C, triglyceride, adiponectin, alpha-tumor necrosis factor (TNF-α), total antioxidant capacity (TAC), gamma-glutamyl transferase (GGT), aspartate aminotransferase (AST), fatty liver index (FLI), fatty liver grade and blood pressure. Conclusion: The ginger supplement may be used as a complementary therapy along with existing therapies to reduce insulin resistance, liver enzymes and inflammation in patients with non-alcoholic fatty liver.

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Section: Discussionmentioning

confidence: 99%

<p>Effect of Ginger Powder Supplementation in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial</p>

Rafie¹,

Hosseini²,

Hajiani³

et al. 2020

CEG

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“…Gujral et al 1978 Ginger (aqueous extract) Decreased LDL-cholesterol, serum total cholesterol, and triacylglycerol. El-Rokh et al 2010 Ginger (gingerol) Prevented high fat diet-induced hyper-lipidemia by cholesterol metabolism. Naidu et al 2016 Coriander (seed oil) Had hypocholesterolemic activities in rats fed a cholesterol-rich diet.…”

Section: Gingermentioning

confidence: 99%

Bioactives in spices, and spice oleoresins: Phytochemicals and their beneficial effects in food preservation and health promotion

Shahidi¹,

Hossain²

2018

JFB

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Spices have broadly been used as food flavoring and folk medicine since ancient times. Numerous phytochemicals have been identified in spices, namely thymol (ajowan and thyme), anethole (aniseed), piperine (black pepper), capsaicin (capsicum), cinnamaldehyde (cinnamon), eugenol (clove), linalool (coriander), sabinene (curry leaf), limonene (dill seed), estragole (fennel seed), allicin (garlic), gingerol (ginger), safranal (saffron), and curcumin (turmeric), among others. The antioxidants in spices are very effective and also render anti-mutagenic, cardioprotective, anti-inflammatory, and anti-cancer properties. Apart from their antioxidant efficacy, spices, particularly their essential oils possess strong antimicrobial activity against bacteria, fungi, yeasts, and microbial toxins synthesis. In this contribution, a summary of the most relevant and recent findings on phytochemical composition and antioxidant properties of spices has been compiled and discussed. The content of phenolic acids, flavonoids, tannins, glycosides, steroids, and terpenoids in different spices are summarized. In addition, the beneficial effects of spices in food preservation and in health promotion and disease risk reduction are briefly described.

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“…Many other medicinal plants showed hypocholesterolemic activity, such as leaf extracts of lupeol and lupeol linoleate [119], Averrhoa bilimbi fruit [120], Cistanche tubulosa extract [121], spirulina [122], peanuts [123], Cnidoscolus chayamansa [124], aqueous ginger (Zingiber officinale) [125], Citrus bergamia Risso and Poiteau juice [126], Momordica charantia fruit [127], cocoa products [128], garlic [129], aç a ı (Euterpe oleracea Mart.) [130], citrus peel [131], Lycium ruthenicum anthocyanins [132], arti choke leaf extract [133], Ficus microcarpa (L.) [134], grape juice [135], Ficus racemosa [136], and Hibiscus sabadariffa extract [137].…”

Section: Miscellaneous Medicinal Plantsmentioning

confidence: 99%

Cholesterol overload impairing cerebellar function: The promise of natural products

El‐Sayyad

2015

Nutrition

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Antihypercholesterolaemic effect of ginger rhizome (Zingiber officinale) in rats

Abstract: The results revealed that the hypercholesterolaemic rats treated with aqueous ginger infusion in the three doses used after 2 and 4 weeks of treatment induce significant decrease in all lipid profile parameters which were measured and improved the risk ratio.

Cited by 62 publications

References 23 publications

<p>Effect of Ginger Powder Supplementation in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial</p>

<p>Effect of Ginger Powder Supplementation in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial</p>

Bioactives in spices, and spice oleoresins: Phytochemicals and their beneficial effects in food preservation and health promotion

Cholesterol overload impairing cerebellar function: The promise of natural products

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