Antihyperalgesic activity of chlorogenic acid in experimental neuropathic pain

Abstract

Chlorogenic acid (CGA) is a natural organic phenolic compound that is found in many plants, fruits and vegetables. CGA has beneficial bioactivities and strong therapeutic effects in inflammatory processes. CGA-rich fractions have analgesic activity but CGA has not been tested previously in neuropathic pain, which results from tissue damage, inflammation or injury of the nervous system. Chronic constrictive nerve injury (CCI) is a peripheral neuropathic pain model which initiates an inflammatory cascade. We aimed to determine possible antihyperalgesic effects of CGA in neuropathic pain. Our study showed for the first time that CGA [50, 100 and 200 mg/kg; intraperitoneally (i.p.)] produced significant dose- and time-dependent antihyperalgesic activity in CCI-induced neuropathic pain. In addition, chronic administration of CGA (100 mg/kg/day; i.p. for 14 days) prevented the development of mechanical hyperalgesia and attenuated CCI-induced histopathological changes. On the other hand, CGA (200 mg/kg) did not affect falling latencies of rats in the rota rod test. Hence, CGA might represent a novel potential therapeutic option for the management of neuropathic pain.

Effects of Systemic Chlorogenic Acid on Random-Pattern Dorsal Skin Flap Survival in Diabetic Rats

“…16,39) CGA, a natural phenolic compound found in human diet, has been reported to exhibit potent antioxidant and antiinflammatory activities. [18][19][20][21]40) Hypoglycemic effects of CGA has been shown in diabetic rats. 23,41) CGA may have particularly beneficial effects on healing as a result of its properties.…”

“…CGA was administered at a dose of 100 mg/kg, and PBS, which was used as a vehicle to dissolve CGA, was administered to the control groups. The dosage of CGA was selected from the effective dose of our previous study 20) and from preliminary experiments for this study (data not shown). The CGA and PBS treatments were started after operation on the surgery day and continued for postoperative six days.…”

“…CGA has strong anti-inflammatory and antioxidant activities. [18][19][20][21] While the exact mechanisms for VEGF expression process are unclear, these activities may involve in it for flap tissue healing. The mechanisms in the effect of CGA on VEGF expression in different situations need further examinations.…”

“…[19][20][21][22][23][24] Experimentally, CGA has been reported to exhibit free-radical scavenging and antagonistic effects against lipid peroxidation in different organs. 11,22,25,26) The effects of topical CGA treatment on an excisional wound model have been investigated recently.…”

Pharmacologic overview of systemic chlorogenic acid therapy on experimental wound healing

“…The antioxidant, anti-inflammatory, radioprotective, antiulcerogenic, and analgesic effects of CGA have been well described (Bagdas et al 2013;Cinkilic et al 2013;Dos Santos et al 2006;Shimoyama et al 2013;Yun et al 2012). Experimentally, CGA has also been reported to have free radical scavenging and antagonistic effects against lipid peroxidation in different organs (Oboh et al 2013;Shimoyama et al 2013;Yun et al 2012).…”