Antihistaminic and antiviral activities of steroids ofTurbinaria conoides

Abstract

The steroids 3,6,17-trihydroxy-stigmasta-4,7,24(28)-triene (A) and 14,15,18,20-diepoxyturbinarin (B) were isolated from the cyclohexane extract of brown alga, Turbinaria conoides (J. Agardh) Kutzing, and have been reported for their antimicrobial activity by us. In this study, the isolated compounds were evaluated for comprehensive antihistaminic, antiviral and cytotoxicity screening. The antihistaminic study was performed using in vitro standard animal models. Evaluation of the potency (EC(50)), affinity (pA(2)) and the maximal response (E(max)) of the histamine alone and in the presence of the compounds were determined. Antiviral activity and cytotoxicity were performed in Crandell-Rees feline kidney (CRFK) cells by a colorimetric formazan-based MTS assay. No significant antiviral activity or cytotoxicity were observed for the compounds in the CRFK cells. Compound A inhibited the histamine-induced concentration at 20 µg mL(-1)(p < 0.05). The most significant inhibition (97%) was observed for compound B (p < 0.01) at the same concentration, which was comparable to that of the positive control chlorpheniramine maleate (10 µg mL(-1)). This potentiality suggests that 14,15,18,20-diepoxyturbinarin (B) can be developed as a new lead antihistaminic agent.

Brown Algae (Phaeophyceae) from the Coast of Madagascar: preliminary Bioactivity Studies and Isolation of Natural Products

“…Fucosterol ( 3 ) has been reported to show anti-oxidant and hepatoprotective activities in rats [ 64 ]. In addition, antihistaminic, anticholinergic, and antiviral activities have been described for fucosterol isolated from T. conoides (J. Agardh) Kutzing [ 65 ]. Saringosterol ( 7 ) has been identified as active principle in the extract of Lessonia nigrescens for the inhibition of Mycobacterium tuberculosis [ 56 ].…”

Screening of Endophytic Fungi from Chlorophyta and Phaeophyta for Antibacterial Activity

“…Antibacterial and antiviral activity has also been reported for polyphenolic compounds derived from brown algae (Phaeophyta) such as Sargassum wightii and Turbinaria ornata [7], and fucosterol from Turbinaria sp. [8,9]. It has been shown that antibacterial activity in macroalgae can be caused by the presence of sulphate polysaccharides (SPs) produced by the seaweeds themselves [10].…”

AKTIVITAS ANTIOKSIDAN SENYAWA NON-POLAR DAN POLAR DARI EKSTRAK MAKROALGA Acanthophora muscoides DARI PANTAI KRAKAL YOGYAKARTA

“…Rumput laut sangat bermanfaat misalnya di bidang kesehatan, enzimologi, dan mikrobiologi (La Barre et al, 2010). Selain itu, rumput laut juga berpotensi sebagai antitumor (Fajarningsih et al,2008), antibakteri (Kantida et al, 2012), antifungi (Kumar et al, 2010), antivirus (Kumar et al, 2009), antifouling (Kantida et al, 2012) dan antioksidan Vijayabakar and Shiyamala (2012).…”