Antihistamine Photosensitivity

Delayed hypersensitivity reaction to the non‐ionic contrast medium iopromid

“…Diphenhydramine (Benadryl 11 \ also used in topical medicaments, is one of the most effective non-sedating antihistamines. Nevertheless, it may induce contact sensitization ( 4-6, 8, 10), photodermatitis (3,9) and eczematous eruptions from oral intake (7). In a computerized surveillance of adverse reactions to drugs in hospital patients, diphenhydramine was one of the most frequent causes (1).…”

Adverse Cutaneous Reactions of Systemic Antihistamines

“…Other reported cutaneous adverse reactions due to diphenhydramine are photosensitivity (< 1%), urticaria, angioedema (< 1%), hyperhidrosis, edema (< 1%), exanthems, fixed eruption, livedo reticularis, pruritus, purpura, rash (< 1%), vasculitis [26], and toxic epidermal necrolysis [5,17]. Photodermatitis due to the systemic administration of ethanolamines such as diphenhydramine and carbinoxamine and to topical ethanolamines are rare [27]. In one report of photoallergy induced by topical diphenydramine therapy, the diagnosis was confirmed by patch testing [28].…”