Antihemophilic Globulin Deficiency

Spontaneous Haemophilia in a Genotypically Normal Female

“…Out of the 24 cases of true haemophilia reported in human females, only 4 cases of true sporadic haemophilia have been described in apparently normal females not verified by chromosomal studies [1,10]. The remaining 20 cases belong to two main groups: the first group consists of 7 cases who are truly homozygous for the classic sex-linked recessive haemophilia gene, and are the product of bleeder-conductor marriage, and the second group includes 13 cases who are assumed to be heterozygous for the ab normal gene which is inherited from the mother.…”

Spontaneous Haemophilia in a Genotypically Normal Female

“…Out of the 24 cases of true haemophilia reported in human females, only 4 cases of true sporadic haemophilia have been described in apparently normal females not verified by chromosomal studies [1,10]. The remaining 20 cases belong to two main groups: the first group consists of 7 cases who are truly homozygous for the classic sex-linked recessive haemophilia gene, and are the product of bleeder-conductor marriage, and the second group includes 13 cases who are assumed to be heterozygous for the ab normal gene which is inherited from the mother.…”

Spontaneous Haemophilia in a Genotypically Normal Female

“…Out of the 24 cases of true haemophilia reported in human females, only 4 cases of true sporadic haemophilia have been described in apparently normal females not verified by chromosomal studies [1,10]. The remaining 20 cases belong to two main groups: the first group consists of 7 cases who are truly homozygous for the classic sex-linked recessive haemophilia gene, and are the product of bleeder-conductor marriage, and the second group includes 13 cases who are assumed to be heterozygous for the ab normal gene which is inherited from the mother.…”

Spontaneous Haemophilia in a Genotypically Normal Female

“…Out of the 24 cases of true haemophilia reported in human females, only 4 cases of true sporadic haemophilia have been described in apparently normal females not verified by chromosomal studies [1,10]. The remaining 20 cases belong to two main groups: the first group consists of 7 cases who are truly homozygous for the classic sex-linked recessive haemophilia gene, and are the product of bleeder-conductor marriage, and the second group includes 13 cases who are assumed to be heterozygous for the ab normal gene which is inherited from the mother.…”