2017
DOI: 10.1155/2017/1256142
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Antiglomerular Basement Membrane Disease in a Pediatric Patient: A Case Report and Review of the Literature

Abstract: Goodpasture's syndrome (GPS) remains a very rare disease entity in the pediatric population characterized by the presence of pulmonary hemorrhage and rapidly evolving glomerulonephritis. We hereby describe the case of a 2-year-old girl who presented with renal failure and was diagnosed with GPS. A brief review of the literature in regard to data on demographics, pathogenesis, clinical features, diagnosis, treatment, and prognosis for renal recovery is also provided.

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Cited by 2 publications
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“…Pediatric anti-glomerular basement membrane (anti-GBM) disease is a rare occurrence accounting for 0.5% cases of end-stage renal disease in pediatric population [ 1 ]. Most cases in the pediatric age group tend to occur in teenagers with a male preponderance [ 2 , 3 , 4 , 5 , 6 ] with the youngest patient being 11 months of age [ 7 ]. It results from antibodies directed against NC1 domains of alpha 3 type IV collagen, and in its typical form presents with disruptive GBM necrotizing lesions/crescents in the kidney and pulmonary hemorrhage [ 8 ].…”
Section: Introductionmentioning
confidence: 99%
“…Pediatric anti-glomerular basement membrane (anti-GBM) disease is a rare occurrence accounting for 0.5% cases of end-stage renal disease in pediatric population [ 1 ]. Most cases in the pediatric age group tend to occur in teenagers with a male preponderance [ 2 , 3 , 4 , 5 , 6 ] with the youngest patient being 11 months of age [ 7 ]. It results from antibodies directed against NC1 domains of alpha 3 type IV collagen, and in its typical form presents with disruptive GBM necrotizing lesions/crescents in the kidney and pulmonary hemorrhage [ 8 ].…”
Section: Introductionmentioning
confidence: 99%
“…Wegener’s granulomatosis and anti-glomerular basement membrane disease are two diagnoses that one may think of when adults present with hemoptysis but are much less common in the pediatric population. Vimal et al describe a case of pediatric hemoptysis caused by Goodpasture’s syndrome in a 2-year-old patient [9]. They describe the difficulty in establishing the diagnosis due to its rarity in children.…”
Section: Discussionmentioning
confidence: 99%