Antigiardial effect of <i>Anethum graveolens </i>aqueous extract in children

Abstract

Background:Giardia lamblia is the most common intestinal parasite of humans identified worldwide. In spite of metronidazole (Met) is the most commonly used drug for the treatment of giardiasis in humans, low patient compliance and side-effects, especially in children encourage efforts to look for new and safe agent; many plants used in folk medicine thought to have antigiardial effect, Anethum graveolens (AG) (dill) is an annual herb cultivated in Iraq used both as a medicinal agent and as food spice. The aim of this study was to investigate the effect of aqueous extract (AE) of AG leave in the treatment of giardiasis, compared with that of standard drug Met.Patients and Methods:A prospective randomized clinical trial was carried out on 28 pediatric patients of both sexes with age of <1 year ranging from 3 to 11 months, who attend to outpatient private clinic in Baghdad for a period of 6 months from June 2013 to December 2013,Patients participate in this study were allocated into two groups Group A composed of 14 patients treated with Met 15 mg/kg 3 times a day for 5 days. Group B composed of 14 patients treated with AGAE 1 ml 3 times a day for 5 days. Stool samples were collected at 0 time before administration of treatment, after 5 days and after 14 days from starting the treatments to check the efficacy of treatment.Results:Administration of AGAE results in a significant decrease in incidence of G. lamblia after 5 days of treatment indicating the efficacy of AGAE in the treatment of giardiasis a result that is comparable to that of Met.Conclusion:This study showed that pediatric patients with giardiasis may benefit from 5 days treatment with AGAE administered as 1 ml 3 times daily, the improvement in the symptom with this herbal agent was comparable to the standard pharmacological agent Met; results showed that AG is safe and tolerable over treatment course.

The Effects of Commercially Available Syzygium aromaticum, Anethum graveolens, Lactobacillus acidophilus LB, and Zinc as Alternatives Therapy in Experimental Mice Challenged with Cryptosporidium parvum

“…The study revealed that 5 days’ consummation of the extract and the regular dose of metronidazole improved symptoms earlier than treatment with metronidazole alone. 69 The second study evaluated the protective effects of dill extracts on amoebic liver abscess through in vivo and in vitro studies at multiple concentrations. The study revealed very promising anti-protozoal effects in comparison to metronidazole effects.…”

Systematic review on medicinal plants used for the treatment of Giardia infection

“… Anethum graveolens Apiaceae Leave Aqueous extract Iraq 1 ml 3 times a day for 5 days Trophozoite-cysts This study showed that pediatric patients with giardiasis may benefit from 5 days treatment with AGAE administered as 1 ml 3 times daily, the improvement in the symptom with this herbal agent was comparable to the standard pharmacological agent Met; results showed that AG is safe and tolerable over treatment course. 2014 ( Sahib et al, 2014 ) Mentha crispa Lamiaceae Leave Aqueous extract Brazil 2 g/day for 10 days Cyst Results showed that the cure rate for the Secnidazole group (84.0%) was significantly higher (P = 0.0002) as that verified in the M. crispa group (47.83%). 2011 ( Teles et al, 2011 ) Triticum Vulgare (Wheat) Poaceae Germ Oil Canada 2 g, 3 times a day for 7 days Cyst In asymptomatic and symptomatic subjects, both cyst passage and coproantigen levels were significantly reduced in those taking WG compared with the placebo group (P < 0.01 and P = 0.06, respectively).…”

Dill

“…Infants younger than 1 year infected by Giardia lamblia, which induces a massive diarrhea, were orally dosed with a water extract of dill leaves (3 times/d) for 5 days. 54 Compared with baseline values, for those given dill extract, the prevalence of Giardia trophozoites or cysts in stools and the frequency of bowel movements Abbreviations: APGAR, score for standard assessment of infant health after delivery (Appearance, Pulse, Grimace, Activity, and Respiration); bw, body weight; C-section, cesarean delivery procedure; F/R ratio, duration of time for a contraction to return to baseline from its peak (fall) divided by the duration of its rise time to its peak (rise); GI, gastrointestinal; HR, heart rate; IV, intravenous; NE, no statistically significant effect. symptoms of infection, which were similar to the outcomes for subjects administered the antifungal agent clotrimazole.…”