Antigenic Relatedness of Selected Flaviviruses: Study With Homologous and Heterologous Immune Mouse Ascitic Fluids

Abstract

The antigenic relationship of 9 flaviviruses, Yellow fever (YF), Wesselsbron (WSL), Uganda S (UGS), Potiskum (POT), West Nile (WN), Banzi (BAN), Zika (ZK), Dengue type 1 (DEN-1) and Dengue type 2 (DEN-2), was assessed by cross-haemagglutination-inhibition (Cross-HI) and cross-complement fixation (Cross-CF) reactions between each of the viruses and their homologous immune mouse ascitic fluids. Titre ratios were calculated using the heterologous and homologous titres. Cross-CF reactions revealed wider antigenic variations among viruses than Cross-HI reactions. There was no significant antigenic variation between WSL, POT and YF viruses using either of those methods. However, definite differences in antigenicity were observed between them and UGS, BAN and ZK viruses. There were no significant differences between UGS, BAN and ZK or between DEN-1 and DEN-2. The serological relationship among flaviviruses is important in establishing diagnosis and epidemiology of these infections in Africa.

Zika Virus

“…However, differences were observed comparing Zika, Banzi, and Uganda S viruses vs. yellow fever, Wesselsbron, and Potiskum viruses in these studies [ 57 ].…”

Antigenic Relatedness Among Newcastle Disease Virus Isolates From Nigerian Feral Birds and the La Śota Strain

“…Generally, a range of R-values ≤ 0.5 or ≥ 2 is an indication that there is a significant antigenic difference between two strains (Baba et al, 1998). In this report, 48.71% of heterologous reactions fall within this range.…”

Hepatitis C virus infection in blood donors from the state of Puebla, Mexico

“…However, of the 96 recovered donors, only 37 (38.5%) were positive to HCV genome detection, and more than 60% of the anti-HCV positive individuals had no viremia. The presence of specific antibodies against HCV and absence of HCV-RNA is a common finding and may be related with one of the following causes: a) the patient has resolved the infection eliminating the virus, b) the infection is so recent and there is no sufficient viral load to detect the virus and the patient should be continuously monitored, or c) there is a cross reaction with antibodies different from anti-HCV [17-21]. …”