Antigenic features and structural correlates of basement membranes. Relationship to epidermolysis bullosa

Fine, Jo‐David

doi:10.1001/archderm.124.5.713

Cited by 14 publications

(7 citation statements)

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“…Similarly, there is now growing literature to support the concept that the abnormal expression of one or more skin BMZ components may result in altered mechanical stability of a portion of the dermoepidermal junction, thereby presumably contributing to the development of blisters (4,12,76). These findings are summarized in Table 1.…”

Section: Altered Bmz Antigenicity In Acquired and Inherited Blisterinmentioning

confidence: 94%

“…Basement membrane zones (BMZ) separate the epidermis and other skin structures (appendageal; neural; vascular; smooth muscle) from direct contact with the underlying or adjacent connective tissue (1)(2)(3). Based upon extensive studies with polyclonal and monoclonal antibodies, it is now known that specific skin-associated BMZs differ not only in location but also in antigenicity (4), thereby suggesting the possible existence of functional differences for each of these BMZs as well as providing an explanation for the observation that the dermoepidermal junction, but not other skin BMZs, is the usual target of immune attack or mechanical instability in selected bullous diseases. In this concise review, the ultrastructure and antigenicity of BMZs in normal adult and fetal skin will be discussed.…”

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confidence: 99%

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Structure and antigenicity of the skin basement membrane zone

Fine¹

1991

J Cutan Pathol

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The skin basement membrane zone is comprised of two major ultrastructural regions, four associated structures, and at least 17 different antigens. In this brief review, the ultrastructure, antigenicity, and ontogeny of normal human skin will be discussed in detail, as will alterations in expression or immune response to selected basement membrane components in specific mechanobullous and autoimmune diseases.

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Section: Altered Bmz Antigenicity In Acquired and Inherited Blisterinmentioning

confidence: 94%

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confidence: 99%

Structure and antigenicity of the skin basement membrane zone

Fine¹

1991

J Cutan Pathol

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“…Classification at both levels remains a problem and currently relies primarily upon ultrastructural investigation of tissue biopsies and immunofluorescence studies using proven markers (Hashimoto et al, 1976;Tidman and Eady, 1985;Fine, 1986Fine, , 1988Gedde-Dahl and Anton-Lamprecht, 1990;BrucknerTuderman et al, 1992). There are no non-invasive diagnostic JDLent Rcs 75(9) 1996 Enamel Chemi procedures available, which represents a considerable problem given the soft-tissue trauma which inevitably accompanies biopsy sampling.…”

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confidence: 99%

The Chemical Composition of Tooth Enamel in Recessive Dystrophic Epidermolysis Bullosa: Significance with Respect to Dental Caries

et al. 1996

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Previous reports have linked the prevalence of tooth abnormalities with high caries experience in the different types of epidermolysis bullosa (EB). However, it is not known to what extent the apparent susceptibility to enamel caries is due to disease-related altered enamel chemistry in these cases. The aim of this study was to characterize the enamel of teeth from patients suffering from recessive epidermolysis bullosa dystrophica (rEBD) in terms of its mineral content, carbonate content, protein content, and amino acid composition. The results showed that dental enamel from these patients was essentially normal in terms of its chemistry. It is therefore concluded that the high caries experience in recessive dystrophic epidermolysis bullosa patients is probably related to other factors, such as compromised oral hygiene and prolonged oral clearance due to extensive oral soft tissue damage and a cariogenic diet.

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“…Currently, the composition at the BM has not been completely elucidated, but a number of the components have been established such as laminin, bullous pemphigoid (BP) antigen, cicatricial pemphigoid antigen, and GB3 in the lamina lucida; and type IV collagen, type VII collagen, heparan sulfate proteoglycan, chondroitin 6-sulfate proteoglycan, LDA-1, and nidogen in the lamina densa. More debatable as to their location are fibronectin and type V collagen (5).…”

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confidence: 99%

Characterization of the changes in matrix molecules at the dermoepidermal junction in lupus erythematosus

1991

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Electron microscopy has revealed that the deposition of immunoglobulin in the skin of lupus erythematosus (LE) patients occurs on and below the basal lamina of the basement membrane (BM). The composition of the BM is now to some extent known, and antibodies have been developed against several of its individual components. In this study, we attempt to elucidate the status of some matrix molecules in the dermoepidermal junction in LE. Lesional and nonlesional skin from LE patients was examined using immunofluoresence microscopy with monoclonal and polyclonal antibodies against 6 matrix molecules. Immunoelectron microscopy using monoclonal antibodies was used to discern changes in type IV and type VII collagen. By immunofluorescence microscopy, type IV collagen, type VII collagen, and fibronectin were altered in lesional skin. There was a statistically significant correlation between the presence of immunoglobulin and alteration of type IV collagen and type VII collagen in lesional skin. The alterations in type IV and type VII collagens were confirmed on immune‐electron microscopy which showed fragmentation of staining of both antigenic components, particularly type IV collagen.

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Antigenic features and structural correlates of basement membranes. Relationship to epidermolysis bullosa

Cited by 14 publications

References 0 publications

Structure and antigenicity of the skin basement membrane zone

Structure and antigenicity of the skin basement membrane zone

The Chemical Composition of Tooth Enamel in Recessive Dystrophic Epidermolysis Bullosa: Significance with Respect to Dental Caries

Characterization of the changes in matrix molecules at the dermoepidermal junction in lupus erythematosus

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