DOI: 10.1084/jem.164.5.1773
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Abstract: The isolation and characterization of structural proteins and genes that encode the a and ,0 chains of the T cell antigen receptor have rapidly advanced our understanding of the molecular biology of these important molecules (1) . However, the central issue of T cell receptor function, how T cells are constrained to recognize antigen only in conjunction with self MHC determinants remains unresolved (2) .A novel approach to this question was suggested by our recent observation (3) that direct (cognate) interact… Show more

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