Antigen‐Inorganic Hybrid Flowers‐Based Vaccines with Enhanced Room Temperature Stability and Effective Anticancer Immunity

Liu, Yijia; Zhu, Xianghui; Lü, Yan; Wang, Xiaoli; Zhang, Chuangnian; Sun, Hongfan; Ma, Guilei

doi:10.1002/adhm.201900660

Cited by 11 publications

(3 citation statements)

References 40 publications

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“…R837-aOVA-ApoE3-HNP, a bionic nano vaccine, one of its components is a membrane phospholipid loaded with antigen ovalbumin (OVA), and it can use macropinocytosis to facilitate antigen presentation of DCs (171). OVA-Cu-HVs, a hybrid vaccine composed of antigen ovalbumin (OVA) and copper (II) sulfate (Cu), was manufactured to serve as a new vector related to macropinocytosis (172). DBMs, drug-loaded anthracyclineloaded bacterial magnetosomes with enhanced anticancer efficiency, can be internalized into HepG2 cells through caveolaemediated macropinocytosis and endocytosis (173).…”

Section: Proteinsmentioning

confidence: 99%

The Dual Role of Macropinocytosis in Cancers: Promoting Growth and Inducing Methuosis to Participate in Anticancer Therapies as Targets

et al. 2021

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Macropinocytosis is an important mechanism of internalizing extracellular materials and dissolved molecules in eukaryotic cells. Macropinocytosis has a dual effect on cancer cells. On the one hand, cells expressing RAS genes (such as K-RAS, H-RAS) under the stress of nutrient deficiency can spontaneously produce constitutive macropinocytosis to promote the growth of cancer cells by internalization of extracellular nutrients (like proteins), receptors, and extracellular vesicles(EVs). On the other hand, abnormal expression of RAS genes and drug treatment (such as MOMIPP) can induce a novel cell death associated with hyperactivated macropinocytosis: methuosis. Based on the dual effect, there is immense potential for designing anticancer therapies that target macropinocytosis in cancer cells. In view of the fact that there has been little review of the dual effect of macropinocytosis in cancer cells, herein, we systematically review the general process of macropinocytosis, its specific manifestation in cancer cells, and its application in cancer treatment, including anticancer drug delivery and destruction of macropinocytosis. This review aims to serve as a reference for studying macropinocytosis in cancers and designing macropinocytosis-targeting anticancer drugs in the future.

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Section: Proteinsmentioning

confidence: 99%

The Dual Role of Macropinocytosis in Cancers: Promoting Growth and Inducing Methuosis to Participate in Anticancer Therapies as Targets

et al. 2021

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“…Laccase@Co 3 (PO 4 ) 2 •HNFs retained 50% of their activity after incubation at pH 9.5 for 3 h, where the free laccase almost lost all of its activity. It should be noted that the stability of laccase@Co 3 (PO 4 ) 2 •HNFs was lower than the free enzyme in acidic pH values due to the solubility of cobalt phosphate in acidic pH 25 . No data is available for comparison.…”

Section: Resultsmentioning

confidence: 97%

“…HNFs-based biocatalysts have been incorporated for the removal of organic contaminations such as phenolic compounds and industrial dyes 23 . Also, due to the pH-responsive release of the immobilized biomolecule, HNFs have been incorporated as a drug delivery platform 25 . It has been reported that after incorporating enzymes into HNFs, their activity, stability, and reusability have notably increased, owing to low mass transfer limitations arising from their high surface-to-volume ratio and cooperative effects between enzymes and metal ions 26 .…”

Section: Introductionmentioning

confidence: 99%

Instantaneous synthesis and full characterization of organic–inorganic laccase-cobalt phosphate hybrid nanoflowers

Vojdanitalab

Jafari-Nodoushan

Mojtabavi

et al. 2022

Sci Rep

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A novel approach termed the "concentrated method" was developed for the instant fabrication of laccase@Co3(PO4)2•hybrid nanoflowers (HNFs). The constructed HNFs were obtained by optimizing the concentration of cobalt chloride and phosphate buffer to reach the highest activity recovery. The incorporation of 30 mM CoCl2 and 160 mM phosphate buffer (pH 7.4) resulted in a fast anisotropic growth of the nanomaterials. The purposed method did not involve harsh conditions and prolonged incubation of precursors, as the most reported approaches for the synthesis of HNFs. The catalytic efficiency of the immobilized and free laccase was 460 and 400 M−1S−1, respectively. Also, the enzymatic activity of the prepared biocatalyst was 113% of the free enzyme (0.5 U mL−1). The stability of the synthesized HNFs was enhanced by 400% at pH 6.5–9.5 and the elevated temperatures. The activity of laccase@Co3(PO4)2•HNFs declined to 50% of the initial value after 10 reusability cycles, indicating successful immobilization of the enzyme. Structural studies revealed a 32% increase in the α-helix content after hybridization with cobalt phosphate, which improved the activity and stability of the immobilized laccase. Furthermore, the fabricated HNFs exhibited a considerable ability to remove moxifloxacin as an emerging pollutant. The antibiotic (10 mg L−1) was removed by 24% and 75% after 24 h through adsorption and biodegradation, respectively. This study introduces a new method for synthesizing HNFs, which could be used for the fabrication of efficient biocatalysts, biosensors, and adsorbents for industrial, biomedical, and environmental applications.

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Bioinspired Multiscale Mineralization: From Fundamentals to Potential Applications

Zuo,

Yang,

Zhang

et al. 2023

Macromolecular Bioscience

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The wondrous and imaginative designs of nature have always been an inexhaustible treasure trove for material scientists. Throughout the long evolutionary process, biominerals with hierarchical structures possess some specific advantages such as outstanding mechanical properties, biological functions, and sensing performances, the formation of which (biomineralization) is delicately regulated by organic component. Provoked by the subtle structures and profound principles of nature, bioinspired functional minerals can be designed with the participation of organic molecules. Because of the designable morphology and functions, multiscale mineralization has attracted more and more attention in the areas of medicine, chemistry, biology, and material science. This review provides a summary of current advancements in this extending topic. The mechanisms underlying mineralization is first concisely elucidated. Next, several types of minerals are categorized according to their structural characteristic, as well as the different potential applications of these materials. At last, a comprehensive overview of future developments for bioinspired multiscale mineralization is given. Concentrating on the mechanism of fabrication and broad application prospects of multiscale mineralization, the hope is to provide inspirations for the design of other functional materials.

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Antigen‐Inorganic Hybrid Flowers‐Based Vaccines with Enhanced Room Temperature Stability and Effective Anticancer Immunity

Cited by 11 publications

References 40 publications

The Dual Role of Macropinocytosis in Cancers: Promoting Growth and Inducing Methuosis to Participate in Anticancer Therapies as Targets

The Dual Role of Macropinocytosis in Cancers: Promoting Growth and Inducing Methuosis to Participate in Anticancer Therapies as Targets

Instantaneous synthesis and full characterization of organic–inorganic laccase-cobalt phosphate hybrid nanoflowers

Bioinspired Multiscale Mineralization: From Fundamentals to Potential Applications

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