Antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy

Min, Yuanzeng; Roche, Kyle C.; Tian, Shaomin; Eblan, Michael J.; McKinnon, Karen P.; Caster, Joseph M.; Chai, Shengjie; Herring, Laura E.; Zhang, Longzhen; Zhang, Tian; DeSimone, Joseph M.; Tepper, Joel E.; Vincent, Benjamin G.; Serody, Jonathan S.; Wang, Andrew Z.

doi:10.1038/nnano.2017.113

Cited by 585 publications

(511 citation statements)

References 37 publications

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“…Studies have shown that during radiotherapy, additional administration of nanoparticles that can specifically absorb neoantigens can enhance the efficacy of antigen‐presenting cells (APCs) in antigen presentation, which further strengthens the abscopal effect and increases the growth inhibition of distal tumors 15. Similar to photodynamic therapy, which can enhance the outcome of checkpoint blockage therapy, a combination of photothermal therapy (PTT, another photo‐induced therapeutic manner) with immune stimulation mediated by carbon nanotubes can enhance the immune response with the subsequent administration of anti‐CTLA‐4 16, 17, 18, 19.…”

Section: Introductionmentioning

confidence: 99%

Photosensitizer Micelles Together with IDO Inhibitor Enhance Cancer Photothermal Therapy and Immunotherapy

et al. 2018

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The therapeutic outcome of photothermal therapy (PTT) remains impeded by the transparent depth of light. Combining PTT with immunotherapy provides strategies to solve this problem. Regulating metabolism‐related enzymes is a promising strategy to stimulate immune response. Here, a nanosystem (NLG919/IR780 micelles) with the properties of photothermal conversion and regulation of the tryptophan metabolic pathway is used to suppress the growth of the tumor margin beyond effective PTT and promote tumor PTT and immunotherapy. It is revealed that mild heat treatment promotes the growth of the tumor margin beyond effective PTT for the upregulation of heat shock protein (HSP), indoleamine 2,3‐dioxygenase (IDO), and programmed death‐ligand 1 (PD‐L1). The NLG919/IR780 micelles can effectively inhibit the activity of IDO but do not affect the level of IDO expression. NLG919/IR780 micelles can effectively accumulate in the tumor and can migrate to lymph nodes and the lymphatic system. In vivo antitumor studies reveal that NLG919/IR780 micelles effectively suppress the growth of tumor margin following PTT in primary tumors. NLG919/IR780 micelle‐mediated PTT and IDO inhibition further stimulate the activation of T lymphocytes, inhibiting the growth of distal tumors (abscopal effect). The results demonstrate that the NLG919/IR780 micelles combine PTT and immunotherapy and suppress the tumor margin as well as distal tumor growth post photothermal therapy.

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Section: Introductionmentioning

confidence: 99%

Photosensitizer Micelles Together with IDO Inhibitor Enhance Cancer Photothermal Therapy and Immunotherapy

et al. 2018

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“…By optimizing the surface properties, they showed that these AC-NPs could deliver the released antigen to APCs and significantly improve the efficacy of anti-PD-1 treatment (Fig. 6) [148]. Currently, confirmed ICD chemo-inducers include oxaliplatin, doxorubicin, mitoxantrone, bortezomib, and cyclophosphamide [149].…”

Section: Application Of Nanomaterials For Cancer Vaccine Designmentioning

confidence: 99%

Nanomaterials for cancer immunotherapy

2017

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Cancer immunotherapy is quickly growing to be the fourth most important cancer therapy, after surgery, radiation therapy, and chemotherapy. Immunotherapy is the most promising cancer management strategy because it orchestrates the body’s own immune system to target and eradicate cancer cells, which may result in durable antitumor responses and reduce metastasis and recurrence more than traditional treatments. Nanomaterials hold great promise in further improving the efficiency of cancer immunotherapy - in many cases, they are even necessary for effective delivery. In this review, we briefly summarize the basic principles of cancer immunotherapy and explain why and where to apply nanomaterials in cancer immunotherapy, with special emphasis on cancer vaccines and tumor microenvironment modulation.

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“…Recent examples are NP that enhance the function of antigen presenting cells leading to strong anti-tumour T cell cytotoxicity [112,113]. A number of biotechnology/pharmaceutical companies are pursuing NP-based vaccines [114].…”

Section: Nanotechnologies For Tissue Engineering and Wearables For Hementioning

confidence: 99%

Deployment and exploitation of nanotechnology nanomaterials and nanomedicine

Matteucci¹,

Giannantonio²,

Calabi³

et al. 2018

AIP Conference Proceedings

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Abstract. Since around 50 years ago, the academic world is developing knowledge and technology to understand and to control matter at the nanoscale in order to exploit the peculiar mechanical, electrical, optical and magnetic properties emerging when a discrete number of atoms is assembled in structures which must be described according to the weird rules of quantum mechanics. This huge know how, commonly named Nanotechnology, was nucleated according to deployment strategies mainly defined and funded worldwide by governmental institutions in order to create the base for their further industrial exploitation and to provide an expectedly large socioeconomic impact. In the following, we will give a brief overview of the main applications of nanomaterials and an estimate of their value, based on the forecasts provided by some market research companies. In particular, we will briefly disclose the application of nanomaterials in the fields of Electronics & ICT, Energy and Environment, and, in particular, in the highly rewarding field of Nanomedicine. Further, we will highlight some key aspects of the deployment policies undertaken around the world which still are a key prerequisite for a full exploitation of the potential of Nanotechnology.

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Antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy

Cited by 585 publications

References 37 publications

Photosensitizer Micelles Together with IDO Inhibitor Enhance Cancer Photothermal Therapy and Immunotherapy

Photosensitizer Micelles Together with IDO Inhibitor Enhance Cancer Photothermal Therapy and Immunotherapy

Nanomaterials for cancer immunotherapy

Deployment and exploitation of nanotechnology nanomaterials and nanomedicine

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