Antifungal interventions for the primary prevention of cryptococcal disease in adults with HIV.

An audit of the screen-and-treat intervention to reduce cryptococcal meningitis in HIV-positive patients with low CD4 count

“…15 , 24 Whilst a 2005 Cochrane review reported a reduction in the incidence of cryptococcal disease, there was no reduction in mortality associated with CCM from such approach. 26 …”

An audit of the screen-and-treat intervention to reduce cryptococcal meningitis in HIV-positive patients with low CD4 count

“…15 , 24 Whilst a 2005 Cochrane review reported a reduction in the incidence of cryptococcal disease, there was no reduction in mortality associated with CCM from such approach. 26 …”

Cryptococcemia in a Patient with Glioblastoma: Case Report and Literature Review

“…In our literature search, we have come across only one other case report 4 describing cryptococcal meningitis in patients with HGG. Extrapolating from studies done on primary prevention of cryptococcal infections in HIV patients, 5 it may be prudent to start patients with CD4<300 cell/uL on antifungal (fluconazole 400mg/day or itraconzole 200mg twice daily) prophylaxis ; in addition to Bactrim. Another, cost effective, alternative would be to monitor the CD 4 counts together with a weekly FBC and to start prophylaxis when the CD4 < 300.…”

Impact of Routine Cryptococcal Antigen Screening and Targeted Preemptive Fluconazole Therapy in Antiretroviral-naive Human Immunodeficiency Virus–infected Adults With CD4 Cell Counts <100/μL: A Systematic Review and Meta-analysis

“…However, to the best of our knowledge, there is no RCT evaluating the effectiveness of this intervention. A placebo-controlled trial would be unethical because there is enough clinical evidence to suggest that fluconazole therapy may reduce the risk of CM in severely immunosuppressed HIV-infected patients [16]. Consequently, in the present review, the impact of this intervention was evaluated based on observational studies.…”

An audit of the screen-and-treat intervention to reduce cryptococcal meningitis in HIV-positive patients with low CD4 count

“…15 , 24 Whilst a 2005 Cochrane review reported a reduction in the incidence of cryptococcal disease, there was no reduction in mortality associated with CCM from such approach. 26 …”

Cryptococcemia in a Patient with Glioblastoma: Case Report and Literature Review

“…In our literature search, we have come across only one other case report 4 describing cryptococcal meningitis in patients with HGG. Extrapolating from studies done on primary prevention of cryptococcal infections in HIV patients, 5 it may be prudent to start patients with CD4<300 cell/uL on antifungal (fluconazole 400mg/day or itraconzole 200mg twice daily) prophylaxis ; in addition to Bactrim. Another, cost effective, alternative would be to monitor the CD 4 counts together with a weekly FBC and to start prophylaxis when the CD4 < 300.…”

Impact of Routine Cryptococcal Antigen Screening and Targeted Preemptive Fluconazole Therapy in Antiretroviral-naive Human Immunodeficiency Virus–infected Adults With CD4 Cell Counts <100/μL: A Systematic Review and Meta-analysis

“…However, to the best of our knowledge, there is no RCT evaluating the effectiveness of this intervention. A placebo-controlled trial would be unethical because there is enough clinical evidence to suggest that fluconazole therapy may reduce the risk of CM in severely immunosuppressed HIV-infected patients [16]. Consequently, in the present review, the impact of this intervention was evaluated based on observational studies.…”

An audit of the screen-and-treat intervention to reduce cryptococcal meningitis in HIV-positive patients with low CD4 count

“…15 , 24 Whilst a 2005 Cochrane review reported a reduction in the incidence of cryptococcal disease, there was no reduction in mortality associated with CCM from such approach. 26 …”

Cryptococcemia in a Patient with Glioblastoma: Case Report and Literature Review

“…In our literature search, we have come across only one other case report 4 describing cryptococcal meningitis in patients with HGG. Extrapolating from studies done on primary prevention of cryptococcal infections in HIV patients, 5 it may be prudent to start patients with CD4<300 cell/uL on antifungal (fluconazole 400mg/day or itraconzole 200mg twice daily) prophylaxis ; in addition to Bactrim. Another, cost effective, alternative would be to monitor the CD 4 counts together with a weekly FBC and to start prophylaxis when the CD4 < 300.…”

Impact of Routine Cryptococcal Antigen Screening and Targeted Preemptive Fluconazole Therapy in Antiretroviral-naive Human Immunodeficiency Virus–infected Adults With CD4 Cell Counts <100/μL: A Systematic Review and Meta-analysis

“…However, to the best of our knowledge, there is no RCT evaluating the effectiveness of this intervention. A placebo-controlled trial would be unethical because there is enough clinical evidence to suggest that fluconazole therapy may reduce the risk of CM in severely immunosuppressed HIV-infected patients [16]. Consequently, in the present review, the impact of this intervention was evaluated based on observational studies.…”