Antifungal efficacy of ursolic acid in control of Alternaria alternata causing black spot rot on apple fruit and possible mechanisms involved

Shu, Chang; Zhao, Hua; Jiao, Wenxiao; Liu, Bangdi; Cao, Jiankang

doi:10.1016/j.scienta.2019.108636

Cited by 62 publications

(31 citation statements)

References 38 publications

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“…Cytoplasmic leakage is considered to be the result of the increase in cytoplasmic membrane permeability. The mode of action to cell membrane may be the insertion of lipophilic group of cinnamaldehyde into the hydrophobic end of plasmalemma, leading the damage of membrane protein which is the main undertaker of biofilm function (Shu et al, 2019). Zhou et al (2018) also found that carvacrol and eugenol could cause the extensive loss of cytoplasm by interfering with the channel proteins on the phospholipid bilayer to destroy the integrity and permeability of cell membrane, which was coincident with our paper.…”

Section: Discussionmentioning

confidence: 99%

The major component of cinnamon oil as a natural substitute against Fusarium solani on Astragalus membranaceus

Wang

Zhang

et al. 2022

Journal of Applied Microbiology

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Aims: Root rot caused by Fusarium solani is an important disease seriously affecting the yield and quality of Astragalus membranaceus. Therefore, this study was performed to elucidate the antifungal activities and mechanisms of cinnamaldehyde treatment against F. solani and its control effect for A. membranaceus root rot. Methods and Results: Cinnamaldehyde significantly inhibited mycelial growth and spore germination of F. solani in dose-dependent, and the median effective concentration was 178.68 μl l −1 . Furthermore, scanning electron microscopy, propidium iodide staining, cell leakage experiments and ergosterol quantitation illuminated that cinnamaldehyde could alter the mycelial morphology, damage the plasma membrane and hinder the biosynthesis of ergosterol. Besides, cinnamaldehyde induced the generation of reactive oxygen species by synergistically upregulating the genes encoded subunits for NADPH oxidase. The disease suppression efficacy of 600 μl l −1 cinnamaldehyde against A. membranaceus root rot was 92.98 ± 6.08% (p < 0.05) under greenhouse conditions. Conclusions: This study proved that cinnamaldehyde could markedly inhibit the growth of F. solani in vitro and effectively suppress the occurrence of A. membranaceus root rot, perhaps by inducing oxidative damage, which results in the distortion of F. solani, and the destruction of cell membrane integrity and permeability. Significance and Impact of the Study: This study first explores the antifungal mechanisms of cinnamaldehyde against F. solani in vivo and vitro, thereby providing a promising candidate for disease biocontrol.

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Section: Discussionmentioning

confidence: 99%

The major component of cinnamon oil as a natural substitute against Fusarium solani on Astragalus membranaceus

Wang

Zhang

et al. 2022

Journal of Applied Microbiology

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“…The main contents of the present review provide an update on reported UA derivatives with potential anticancer activities reported over the last five years (2015-2020). 3 Antifungal [111][112][113][114][115][116][117] 4…”

Section: An Overview Of Pharmacokinetics Of Ua and Its Derivativesmentioning

confidence: 99%

Ursolic Acid-Based Derivatives as Potential Anti-Cancer Agents: An Update

Khwaza

Oyedeji

Aderibigbe

2020

IJMS

115

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Ursolic acid is a pharmacologically active pentacyclic triterpenoid derived from medicinal plants, fruit, and vegetables. The pharmacological activities of ursolic acid have been extensively studied over the past few years and various reports have revealed that ursolic acid has multiple biological activities, which include anti-inflammatory, antioxidant, anti-cancer, etc. In terms of cancer treatment, ursolic acid interacts with a number of molecular targets that play an essential role in many cell signaling pathways. It suppresses transformation, inhibits proliferation, and induces apoptosis of tumor cells. Although ursolic acid has many benefits, its therapeutic applications in clinical medicine are limited by its poor bioavailability and absorption. To overcome such disadvantages, researchers around the globe have designed and developed synthetic ursolic acid derivatives with enhanced therapeutic effects by structurally modifying the parent skeleton of ursolic acid. These structurally modified compounds display enhanced therapeutic effects when compared to ursolic acid. This present review summarizes various synthesized derivatives of ursolic acid with anti-cancer activity which were reported from 2015 to date.

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“…With respect to the physiological function of pentacyclic triterpenoids these compounds are considered as part of a defense system which defends plant against environmental stress, wound and injuries repair mechanism and enhanced the resistance against plant pathogens [12,13]. A variety of infectious organisms were reported inhibited by triterpenoids compounds, including fungi, viruses, bacteria, protozoa and parasites [14].…”

Section: Sift Deskmentioning

confidence: 99%

“…A variety of infectious organisms were reported inhibited by triterpenoids compounds, including fungi, viruses, bacteria, protozoa and parasites [14]. So, in these senses it has been shown as UA is an efficient antifungal against the infection of apple by Alternaria alternata that could be a useful alternative for this disease management [13]. Also, OA and BA exert an inhibitory activity against influenza virus and hepatitis C virus infection binding to viral fusion proteins and disrupting viral entry into the host cells [14].…”

Section: Sift Deskmentioning

confidence: 99%

TIME COURSE PROFILE OF PENTACYCLIC TRITERPENES FROM STEM AND ROOT OF CV. PICUAL OLIVE TREE (Olea europaea, L.) ALONG RIPENING

Peragón¹,

HERNÁNDEZ-YERA²

2020

SDRP-JPS

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Background: Pentacyclic triterpenes are plant secondary metabolites that have many applications for health of the people. Methods: In this work, we determine by a HPLC-UV/Vis and HPLC-MS what pentacyclic triterpenes are found in stem and root of cv. Picual olive tree, a variety typically grown in the area of Jaén (Spain). Moreover, the concentration of these compounds along fruit ripening also has been determined in both organs. Results: Maslinic acid (MA), oleanolic acid (OA), erythrodiol (EO), and uvaol (UO) have been found in stem. OA is the compound that shown the highest concentration in this organ. MA, betulinic acid (BA), OA and ursolic acid have been found in root. In general, BA has the highest concentration in this organ. BA had not been detected in other olive tree organs. Conclusion: The evolution showed by the concentrations of these compounds during ripening suggests the existence of two different phases: the first related with the increment in weight of fruit and the second related with the ripening following. The evolution found in stem is different to the found in root and we believe that are related with the functions of these compounds in each organ.

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Antifungal efficacy of ursolic acid in control of Alternaria alternata causing black spot rot on apple fruit and possible mechanisms involved

Cited by 62 publications

References 38 publications

The major component of cinnamon oil as a natural substitute against Fusarium solani on Astragalus membranaceus

The major component of cinnamon oil as a natural substitute against Fusarium solani on Astragalus membranaceus

Ursolic Acid-Based Derivatives as Potential Anti-Cancer Agents: An Update

TIME COURSE PROFILE OF PENTACYCLIC TRITERPENES FROM STEM AND ROOT OF CV. PICUAL OLIVE TREE (Olea europaea, L.) ALONG RIPENING

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