2014
DOI: 10.1590/1807-3107bor-2014.vol28.0049
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Antifungal effect of electrospun nanofibers containing cetylpyridinium chloride against Candida albicans

Abstract: It is known that cetylpyridinium chloride (CPC) has in vitro and in vivo antifungal action against Candida albicans, with advantages over other common antiseptics. A CPC delivery-controlled system, transported in polymer nanofibers (PVP/PMMA), was developed to increase the bioavailability of the drug in contact with the oral mucosa. The objectives of this study were to determine if CPC in nanofiber has antifungal action against C. albicans, and in what concentration it must be incorporated, so that the fractio… Show more

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Cited by 13 publications
(3 citation statements)
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“…Cetylpyridinium chloride (CPC) is a quaternary ammonium compound used in mouth-rinses and topical formulations, presenting antifungal activity [ 8 , 9 , 10 ]. Its effects have been shown to be superior to miconazole [ 9 ], also presenting high efficacy in reducing C. albicans adhesion to the oral mucosa [ 11 ].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Cetylpyridinium chloride (CPC) is a quaternary ammonium compound used in mouth-rinses and topical formulations, presenting antifungal activity [ 8 , 9 , 10 ]. Its effects have been shown to be superior to miconazole [ 9 ], also presenting high efficacy in reducing C. albicans adhesion to the oral mucosa [ 11 ].…”
Section: Introductionmentioning
confidence: 99%
“…Cetylpyridinium chloride (CPC) is a quaternary ammonium compound used in mouth-rinses and topical formulations, presenting antifungal activity [ 8 , 9 , 10 ]. Its effects have been shown to be superior to miconazole [ 9 ], also presenting high efficacy in reducing C. albicans adhesion to the oral mucosa [ 11 ]. However, the low substantivity of CPC [ 12 ] can be considered as a drawback of therapies involving this agent due to the need for frequent exposure, which may result in antimicrobial resistance by some Candida strains [ 13 , 14 ].…”
Section: Introductionmentioning
confidence: 99%
“…12 Cetylpyridinium chloride is an antiplaque and toxinneutralizing for maximum antimicroorganism protection. 14,15 Its high advantage is the low coloration and staining degree compared to CHX. 15 The reinforcement of CHX with CPC helps neutralize the toxins released by microorganisms in the mouth.…”
Section: Introductionmentioning
confidence: 99%