Antifungal and anti-inflammatory potential of Lavandula stoechas and Thymus herba-barona essential oils

Zuzarte, Mónica; Gonçalves, María José; Cavaleiro, Carlos; Cruz, Maria Teresa; Benzarti, Anissa; Marongiu, Bruno; Maxia, Andrea; Piras, Alessandra; Salgueiro, Lı́gia

doi:10.1016/j.indcrop.2012.11.002

Cited by 92 publications

(77 citation statements)

References 25 publications

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“…This antifungal activity is comparable to that reported by [22, 24]. The stronger activity of the essential oil of C. nardus and C. citriodora against fungal species may also be because of the antifungal properties of citronellal.…”

Section: Resultssupporting

confidence: 87%

Fumigant Antifungal Activity ofCorymbia citriodoraandCymbopogon nardusEssential Oils and Citronellal against Three Fungal Species

Aguiar

Ootani

Ascêncio

et al. 2014

The Scientific World Journal

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Corymbia citriodora and Cymbopogon nardus essential oils samples were analyzed by GC and GC-MS and their qualitative and quantitative compositions established. The main component of essential oils of C. citriodora and C. nardus was citronellal, at 61.78% and 36.6%, respectively. The essential oils and citronellal were tested for their fumigant antifungal activity against Pyricularia (Magnaporthe) grisea, Aspergillus spp., and Colletotrichum musae. The minimum inhibitory concentration (MIC) ranged from 100 to 200 ppm for the essential oils and 25 to 50 mg·mL−1 for citronellal. The contact assay using the essential oils and citronellal showed growth inhibition of the three fungal species. However, a concentration of 1.47 mg·mL−1 only reduced the inhibition of Aspergillus growth to 90% at 14 days of exposure. For the fumigant assay, 0.05, 0.11, and 0.23 mg·mL−1 of essential oils and citronellal drastically affected growth of P. grisea, Aspergillus spp., and C. musae. Harmful effects on the sporulation and germination of the three fungi were seen, and there was complete inhibition at 0.15 mg·mL−1 with both oils and citronellal. This showed that the crude component of essential oils of C. citriodora and C. nardus markedly suppressed spore production, germination, and growth inhibition of P. grisea, Aspergillus spp., and Colletotrichum musae.

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Section: Resultssupporting

confidence: 87%

Fumigant Antifungal Activity ofCorymbia citriodoraandCymbopogon nardusEssential Oils and Citronellal against Three Fungal Species

Aguiar

Ootani

Ascêncio

et al. 2014

The Scientific World Journal

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“…This may be due to an increasing in photosynthetic activity which induces a high rate of biosynthesis of volatile compounds (mainly the phenolic compounds) at full flowering stage [4]. Some monoterpenes constituents (cymene, γ-terpinene, carvacrol and p-cimene-7-ol) were absent (or present at very low concentrations) in the different EOs when the plants were harvested before flowering (Table 5) [28]. Additionally, in their study on the antioxidant capacity of some Lamiaceae species, Khled Khoudja et al [29] confirmed that T. algeriensis containing high phenolic compounds showed a strong ability to act as an antioxidant agent.…”

Section: Effect Of Growth Stage On the Chemical Composition Of Thymusmentioning

confidence: 99%

Phytochemical Characterization of the Essential Oils Obtained from Mediterranean Thymus spp. (Lamiacea) Harvested at Different Stages of Growth

Touhami¹,

Chefrour²,

Khellaf³

et al. 2017

JPP

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Abstract:To prove more information on the chemical composition of the essential oils of Thymus taxa collected in different Algeria areas, and to determine the effect of harvesting periods on the composition of these essential oils: three Thymus species (T. numidicus, T.ciliatus and T. algeriensis) were collected during two periods of development, the EOs (essential oils) obtained by steam distillation of the aerial parts were analyzed by GC/MS (gas chromatography coupled with mass spectrometry). During the pre-flowering stage, the RP% (relative percentage) of Eos varied between 1.00% and 1.34% for all the species. The content of EOs increased during the flowering stage and reached particularly 2.10% and 2.85% for T. numidicus (from Berrahal) and T. numidicus (from Tacha), respectively. GC/MS analysis showed that these oils are very rich in oxygenated monoterpenes group (76.96%~82.11%) when the plants were harvested during the flowering stage of growth. Thymol was the major compound in the EOs contained in T. numidicus (Berrahal) and T. ciliatus with more than 39% and 54%, respectively. Thymus numidicus (Tacha) and T. algeriensis EOs were characterized by high content in p-cimene-7-ol (78.06% and 26.98%, respectively). These two chemotypes (thymol and p-cimene-7-ol) are considered as antioxidant and antimicrobial agents providing the basis for many applications in processed food preservation and pharmaceutical products.

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“…Iranian plants, such as Lavandula stoechas) (known as Ostokhodos), C. cyminum (known as Ziree) and Artemisia sieberi (known as Dermane) have been used for centuries as herbal remedies by local or regional subjects (6,7). Several reports indicated the inhibitory activities of essential oils of the above-mentioned plants against different fungal agents (8)(9)(10). This study evaluated the antifungal activity of L. stoechas, C. cyminum and A. sieberi essential oils against clinical strains of Malassezia from the skin of patients with Malassezia dermatitis.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effect of plant essential oils on Malassezia strains from Iranian dermatitis patients

Naeini¹,

Nazeri²,

Shokri³

2017

J Herbmed Pharmacol

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The essential oils of C. cyminum, L. stoechas and A. sieberi showed promising antifungal effects against Malassezia strains from patients with Malassezia dermatitis as important fungal pathogens. Hence, these essential oils, especially C. cyminum, could be used to develop an effective therapy against skin infections caused by Malassezia strains.Please cite this paper as: Naeini AR, Nazeri M, Shokri H. Inhibitory effect of plant essential oils on Malassezia strains from Iranian dermatitis patients . J Herbmed Pharmacol. 2018;7(1):18-21. doi: 10.15171/jhp.2018.04. Introduction:The genus Malassezia is an important skin resident of human. The present study aimed to analyze in vitro activity of the essential oils of Lavandula stoechas, Cuminum cyminum and Artemisia sieberi against clinical strains of Malassezia species. Methods: A total of 47 Malassezia strains, including Malassezia furfur, Malassezia globosa and Malassezia obtuse, were used in this study. A disk diffusion technique was selected for testing the susceptibility of Malassezia strains to the essential oils. Results: All the essential oils showed in vitro activity against Malassezia strains, with M. furfur and M. obtusa being the highest and lowest susceptible of the strains, respectively. The highest antifungal activity was associated with the essential oil of C. cyminum (mean ± SD: 50.0 ± 0.0 mm), followed by L. stoechas (mean ± SD: 46.8 ± 3.1 mm) and A. sieberi (mean ± SD: 36.9 ± 5.7 mm). The inhibition zone ranges were 12.5 to 15.6 mm (mean ± SD: 14.4 ± 1.6 mm) for ketoconazole and 11.6 to 13.3 mm (mean ± SD: 12.4 ± 0.9 mm) for fluconazole. Although all the antifungal drugs were found to possess good antifungal activities against Malassezia strains, their effects were lower than the activities shown by the essential oils tested (P < 0.05). Conclusion: These results indicated that the essential oils tested, especially the one from C. cyminum, inhibited the growth of clinical strains of Malassezia, implying its potential use in the treatment of Malassezia infections. This indicates that this plant may be useful in preparation of new drugs.

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Antifungal and anti-inflammatory potential of Lavandula stoechas and Thymus herba-barona essential oils

Cited by 92 publications

References 25 publications

Fumigant Antifungal Activity ofCorymbia citriodoraandCymbopogon nardusEssential Oils and Citronellal against Three Fungal Species

Fumigant Antifungal Activity ofCorymbia citriodoraandCymbopogon nardusEssential Oils and Citronellal against Three Fungal Species

Phytochemical Characterization of the Essential Oils Obtained from Mediterranean Thymus spp. (Lamiacea) Harvested at Different Stages of Growth

Inhibitory effect of plant essential oils on Malassezia strains from Iranian dermatitis patients

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