Antifungal activity of Uncaria tomentosa (Willd.) D.C. against resistant non-albicans Candida isolates

Significance and Impact of the Study: The failure to respond to antifungal therapy is complex and is associated with microbiological resistance and increased expression of virulence in fungal pathogens. Thus, this review offers an overview of current challenges in the treatment of fungal infections associated with increased antifungal drug resistance and the formation of biofilms in these opportunistic pathogens. Furthermore, the most recent and potential strategies to combat fungal pathogens are explored here, focusing on new agents as well as innovative approaches, such as combination therapy between antifungal drugs or with natural compounds. AbstractUndeniably, new antifungal treatments are necessary against pathogenic fungi. Fungal infections have significantly increased in recent decades, being highlighted as important causes of morbidity and mortality, particularly in immunocompromised patients. Five main antifungal classes are used: (i) azoles, (ii) echinocandins, (iii) polyenes, (iv) allylamines and (v) pyrimidine analogues. Moreover, the treatment of mycoses has several limitations, such as undesirable side effects, narrow activity spectrum, a small number of targets and fungal resistance, which are still of major concern in clinical practice. The discovery of new antifungals is mostly achieved by the screening of natural or synthetic/semisynthetic chemical compounds. The most recent discoveries in drug resistance mechanism and their avoidance were explored in a review, focusing on different antifungal targets, as well as new agents or strategies, such as combination therapy, that could improve antifungal therapy.

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“…albicans and potentiating its action (Moraes et al . ). Studies have shown that Brazilian Red Propolis (Pippi et al .…”

Section: Combination Of Antifungals With Natural Compoundsmentioning

confidence: 97%

“…); (vi) water‐insoluble fraction of Uncaria tomentosa Willd (Moraes et al . ) (vii) Artemisia sieberi Besser (Mahboubi and Kazempour ). All presented antifungal activity against yeast and filamentous fungi.…”

Section: Strategies To Combat Fungal Resistancementioning

confidence: 99%

Antifungals discovery: an insight into new strategies to combat antifungal resistance

Fuentefría

Pippi

Lana

et al. 2018

Letters in Applied Microbiology

129

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“…They are currently researched for anti-inflammatory [58], anti-oxidant [58], denture stomatitis [59], haemorrhagic cystitis [60] and anti-fungal activity [61]. It has also claimed to have a leucocytopenic activity, especially the elevation of monocytes.…”

Section: Leucocytopeniamentioning

confidence: 99%

Herbal approach in the treatment of pancytopenia

Bagwe

Kale

Bhatt

et al. 2017

Journal of Complementary and Integrative Medicine

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Abstract:Pancytopenia is a health condition in which there is a reduction in the amount of leucocytes, erythrocytes and thrombocytes. If more than one of the blood cells is low then the condition is called as bicytopenia. The pancytopenic condition is observed in treatment of diseased conditions like thalassemia and hepatitis C. Iatrogenically pancytopenia is caused by some antibiotics and anti-HCV drugs. Medical conditions like aplastic anaemia, lymphoma, copper deficiency, and so forth can also cause pancytopenia. Pancytopenia can in turn decrease the immunity of the person and thereby can be fatal. Current therapies for pancytopenia include bone marrow stimulant drugs, blood transfusion and bone marrow transplant. The current therapies are very excruciating and have long-term side-effects. Therefore, treating these condition using herbal drugs is very important. Herbs like wheatgrass, papaya leaves and garlic are effective in treating single lineage cytopenias. The present review is focused on the potential effects of natural herbs for the treatment of pancytopenia.

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“…The previous study documented the antimicrobial effect of U. tomentosa bark extracts against several morphological forms of Borrelia burgdorferi and respiratory pathogens namely Enterococcus faecalis, Pseudomonas aeruginosa and Staphylococcus aureus and this activity were attributed to the presence of proanthocyanidins, including dimers and oligomers up to undecamers [43]. U. tomentosa showed remarkable antifungal efficacy against various anidulafungin, terbinafine and fluconazole-resistant non-albicans species [44]. The antiprotozoal activity has been recently documented by Batiha et al [45] against Babesia and Theileria parasites and this efficacy was attributed to its ability to digest harmful microorganisms.…”

Section: Antimicrobial Antiprotozoal and Antiviral Activitiesmentioning

confidence: 96%

Uncaria tomentosa (Willd. ex Schult.) DC.: A Review on Chemical Constituents and Biological Activities

et al. 2020

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Uncaria tomentosa (Willd. ex Schult.) DC. (Family: Rubiaceae), commonly known as cat’s claw, is a tropical medicinal vine originating at the Amazon rainforest and other areas of South and Central America. It has been traditionally used to treat asthma, abscesses, fever, urinary tract infections, viral infections, and wounds and found to be effective as an immune system rejuvenator, antioxidant, antimicrobial, and anti-inflammatory agent. U. tomentosa is rich in many phytoconstituents such as oxindole and indole alkaloids, glycosides, organic acids, proanthocyanidins, sterols, and triterpenes. Biological activities of U. tomentosa have been examined against various microorganisms and parasites, including pathogenic bacteria, viruses, and Plasmodium, Babesia and Theileria parasites. Several formulations of cat’s claw (e.g., tinctures, decoctions, capsules, extracts, and teas) are recently available in the market. The current review covers the chemical constituents, biological activities, pharmacokinetics, and toxic properties of U. tomentosa extracts.

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Antifungal activity of Uncaria tomentosa (Willd.) D.C. against resistant non-albicans Candida isolates

Cited by 18 publications

References 43 publications

Antifungals discovery: an insight into new strategies to combat antifungal resistance

Antifungals discovery: an insight into new strategies to combat antifungal resistance

Herbal approach in the treatment of pancytopenia

Uncaria tomentosa (Willd. ex Schult.) DC.: A Review on Chemical Constituents and Biological Activities

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