Antifungal Activity of Senna alata – A Review

Ashfaq, Muhammad Hamza; Yousaf, Muhammad Hassan

doi:10.52711/2231-5691.2022.00050

Cited by 4 publications

(3 citation statements)

References 24 publications

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“…According to Alonso-Castro et al, 2021 in this review, diarrhoea is a common side effect of many natural products used for self-medication, and it can be caused by a variety of factors. Some herbs, such as aloe vera and senna, have laxative effects that can cause diarrhoea (Ashfaq & Yousaf, 2022). Alotiby et al, 2021 identi ed Stomach pain in this review as a major side effect of herbal medicine use, particularly if the herbs are taken on an empty stomach or in large amounts, a nding corroborated by Tripathi & Bahuguna (2022).…”

Section: Discussionmentioning

confidence: 64%

Critical Assessment of the Implications of Self-medication With Natural Products During Disease Outbreaks Among People in Developing Countries

Adebiyi¹

2023

Preprint

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Background: Self-medication with natural products during disease outbreaks is a major public health challenge in developing countries. Unlike self-medication with Over the counter (OTC) medication which receives significant attention in published literature, natural products have significant health implications, especially during times of disease outbreaks which are yet to be fully explored. Not backed by scientific evidence, the act can lead to a false sense of security among people, leading to a further spread of the disease amongst other implications. People need to be informed about self-medication risks and the professionally prescribed benefits of natural products and to seek appropriate medical care when necessary. Objectives: The purpose of this dissertation is to assess the implications of self-medication with natural products during disease outbreaks among people in developing countries. It tries to answer the following questions: (1) what is the state and quality of evidence in current literature (2) what are the gaps in literature (3) what are the determinants and contributing factors to self-medication with natural products during disease outbreaks among people in developing countries (4) what are the implications and (5) what are the possible solutions? Method: This dissertation was conducted using a modified systematic literature review methodology. The search protocol utilised for the search and selection of relevant materials from literature used in synthesising the findings of the study was documented using the PRISMA. The database search result was selected for review after the application of limiters, duplicate removals, exclusion and inclusion criteria, full-text review, and screening. The final selected articles were assessed for quality and bias using the 20 points system in AXIS critical evaluation tool. Data were extracted into themes using a Microsoft word table from which findings were synthesised. Findings: The initial database search yielded 1,683 reports from which 20 articles were selected for the review. Overall, 71.4% of the 14 articles assessed for quality and bias accrued 15 or more points on the 20 points system in AXIS critical evaluation tool, indicating that they were relatively of good quality. While all twenty (20) articles mentioned at least three or more factors or determinants of self-medication with natural products during disease outbreaks, only six (6) articles mentioned one or more implications, therefore demonstrating that there is a dearth in literature in this regard, which needs more exploration. The findings indicate that women are more likely to self-medicate with natural products than men, acquisition and ideological factors had the most influence on self-medication while the most common side effects were Diarrhoea, Stomach pain, Sweating, Headache, and Nausea/vomiting. Findings indicate that steam inhalation and herbal baths increased the risk of COVID-19 infection and people who self-medicate with natural products are more withdrawn and had less communication with their physicians. These people may suffer side effects not reported to their doctor and this might account for the paucity of reports on the implications of natural products used during disease outbreaks. Conclusion and implication of key finding:The use of natural products for self-medication during disease outbreak is a rampant practice in developing countries. While natural products may be more readily available, accessible, and affordable, there are potential risks and implications of natural products' use for self-medication. People need to be informed about this, encouraged to speak about their predicaments and seek appropriate medical care and support when necessary.

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Section: Discussionmentioning

confidence: 64%

Critical Assessment of the Implications of Self-medication With Natural Products During Disease Outbreaks Among People in Developing Countries

Adebiyi¹

2023

Preprint

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“…Traditional remedies have few negative side effects and do not lead to resistance. C. alata leaves can be used to treat pinworms and fungal infections on the skin, such as tinea versicolor, ringworm, eczema, thrush, and itching [4]. Based on our initial research, the activity of ethanol extracts of C.alata leaves against C. albicans fungi shows that ethanol extracts of C.alata leaves at a concentration of 1.25% produce an inhibition zone of 18.0 ± 0 mm, where the value is greater than the 2% ketoconazole inhibition zone, which is 11.0 ± 0 mm.…”

Section: Introductionmentioning

confidence: 99%

Effect of pH variation on chemical components and antifungal activity of ketepeng cina (Cassia alata L.) leaves extract

Masyita,

Barokah,

Anggraeni

et al. 2024

IOP Conf. Ser.: Earth Environ. Sci.

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Ketepeng cina (Cassia alata, L.) has been widely used as a traditional medicine, one of which is as an antifungal. Previous research showed problems with the storage of ketepeng cina leaves extract, which reported changes in pH and color over time. This study explored the effect on concentration of chemical components and antifungal activity under varying pH. Antifungal activity against Candida albicans was tested using microdilution and well diffusion methods. HPTLC technique was measured the chemical components of the extract represented by aloe-emodin and kaempferol concentration. The extract with pH 4.5 had the highest aloeemodin content and antifungal activity. The result of our research were the pH variation significant influence on anti fungal activity against C.albicans, where the best results are at pH 5.5 (p<0.05). The level of active components in the extract is influenced by the pH conditions (p<0.05). Specifically, the levels of kaempferol and aloe-emodin are maximum at a pH of 5.5. It can be concluded that pH can affect the levels of chemical components and antifungal activity in ethanol extracts of ketepeng cina (Cassia alata, L.) leaves.

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“…Many studies have been carried out on the efforts of seed germination in various plants of various species, including medicinal plants. Several studies have been reported on the propagation of S. alata [2,8,9].…”

Section: Introductionmentioning

confidence: 99%

A study on seed germination of Senna alata (L.) (ketepeng)

Garvita¹,

Ismaini²,

Damayanti³

et al. 2023

IOP Conf. Ser.: Earth Environ. Sci.

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Senna alata (L.) Roxb., locally known as “Ketepeng China” from the family of Fabaceae, is a shrub or small tree that is used as an ornamental flowering shrub and for medicinal purposes in tropical and subtropical countries. Various parts of S. alata plant (leaves, flowers, roots, or stem) are used in traditional medicines to treat typhoid, diabetes, malaria, asthma, ringworms, scabies, and eczema. The present study was designed to investigate plant conservation by establishing an efficient seed germination method. The seeds of S. alata responded differently in growth to each location and medium. The best result-produced seedlings are grown in pots filled with sand, both at Bogor and Cibodas. The percentage of seed germination on sand was higher (around 96.7%) than on husk media (about 10%) for 10 planting days.

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Antifungal Activity of Senna alata – A Review

Cited by 4 publications

References 24 publications

Critical Assessment of the Implications of Self-medication With Natural Products During Disease Outbreaks Among People in Developing Countries

Critical Assessment of the Implications of Self-medication With Natural Products During Disease Outbreaks Among People in Developing Countries

Effect of pH variation on chemical components and antifungal activity of ketepeng cina (Cassia alata L.) leaves extract

A study on seed germination of Senna alata (L.) (ketepeng)

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