Antifungal activity of five species of Polygala

Johann, Susana; Mendes, Beatriz Garcia; Missau, Fabiana Cristina; Resende, Maria Aparecida de; Pizzolatti, Moacir Geraldo

doi:10.1590/s1517-83822011000300027

Cited by 41 publications

(23 citation statements)

References 14 publications

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“…activity through tests of broth microdilution in standard strains isolated from humans and felines (Verástegui et al, 1996;Johann et al, 2007;Luqman et al, 2007;Cleff et al, 2008;Fatima et al, 2009;Johann et al, 2011;Joshi et al, 2011;Stopiglia et al, 2011). This method is based on the proportion of microbial growth in liquid medium challenged with the concentration of the measured substance using a 96-well microplate (CLSI, 2002;Pinto et al, 2003).…”

Section: Broth Microdilution Methodsmentioning

confidence: 99%

“…From the plants used in traditional medicine in Brazil, Johann et al (2011) exhibited that ethanolic and ethyl acetate extracts of Rubus urticaefolius (Rosaceae) inhibited the fungal growth at the concentration of 125 μg mL -1 , while Rumex acetosa (Polygonaceae) demonstrated activity at 1000 μg mL -1 . The same activity was observed in the essential oil of Lobelia pyramidalis (Campanulaceae), which inhibited the fungal growth at MIC of 6.25 mg mL -1 (Joshi et al, 2011).…”

Section: Broth Microdilution Methodsmentioning

confidence: 99%

“…The authors isolated the compounds "prenyloxycoumarin" and "1,2,3,4,5,6-hexanehexol" from P. sabulosa and these showed activity in the MIC value of 125 μg mL -1 and 250 μg mL -1 , respectively (Johann et al, 2011). Stopiglia et al (2011) demonstrated in vitro efficacy of plants from the Pterocaulon genus (Asteraceae family) against 24 strains of S. schenckii, and the methanolic extract at 10% of P. polystachyum, P. lorentzii, P. lanatum, P. cordobense and P. balansae had inhibitory and fungicidal activity.…”

Section: Broth Microdilution Methodsmentioning

confidence: 99%

“…In the studies reviewed, the methodology utilized for research on plants were agar diffusion (Apisariyakul et al, 1995;Saikia et al, 2001;Rojas et al, 2003;Luqman et al, 2007;Damián-Badillo et al, 2008;Verástegui et al, 2008;Fatima et al, 2009;Márquez, 2010;Joshi et al, 2011), broth microdilution technique (Sinha, Gulati, 1990;Verástegui et al, 1996;Johann et al, 2007;Luqman et al, 2007;Cleff et al, 2008;Fatima et al, 2009;Johann et al, 2009Johann et al, , 2011Joshi et al, 2011), bioautographic assay (Betina, 1973;Johann et al, 2007;, serial microdilution at 24 and 48 hours (Masoko, Picard, Eloff, 2005;2007;Suleiman et al, 2009) and agar cup method (Salomão et al, 2008).…”

Section: In Vitro Susceptibility Testsmentioning

confidence: 99%

“…of certain medicinal plants (Rojas et al, 2003;Masoko, Picard, Eloff, 2007;Cleff et al, 2008;Suleiman et al, 2009;Johann et al, 2011;Joshi et al, 2011;Stopiglia et al, 2011). However, there is a lack of standardization of tests with medicinal plants and this makes the comparison of antifungal activity of the plants difficult.…”

Section: Introductionmentioning

confidence: 99%

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Anti- Sporothrix spp. activity of medicinal plants

Waller

Madrid

Faria

et al. 2016

Braz. J. Pharm. Sci.

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Cases of sporotrichosis in humans and animals without satisfactory clinical response have increased, a warning sign of strains resistant to conventional antifungal agents. The urgent search for alternative therapies was an incentive for research on medicinal plants with anti-Sporothrix spp. properties. A bibliographic survey was performed based on scientific papers about in vitro and in vivo antifungal activity of essential oils and extracts of plants in differents solvents against the fungal of the Sporothrix schenckii complex. The study methodology consisted of a literature review in Google Scholar, Science Direct, Pubmed, Bireme and Springer link with papers from 1986 to 2015. We found 141 species of plants that were investigated, of which 100 species were concentrated in 39 botanical families that had confirmed anti-Sporothrix activity. Combretaceae, Asteraceae and Lamiaceae represented the botanical families with the greatest number of plants species with antifungal potential, using different methodologies. However, there are few studies with medicinal plants in experimental infection in animals that prove their activity in the treatment of sporotrichosis. It reinforces the need for further research related to standardization of in vitro methodologies and in vivo studies related to safety and to toxicity potential of these plants with anti-Sporothrix spp. activity.Uniterms: Sporothrix schenckii complex. Antifungals. Combretaceae/pharmacognosy. Asteraceae/ pharmacognosy. Lamiaceae/pharmacognosy. Medicinal plants/antifungal activity.Casos de esporotricose em humanos e animais sem resposta clínica satisfatória têm aumentado, sinal de alarme para o surgimento de cepas resistentes aos antifúngicos convencionais. A urgente busca por alternativas terapêuticas tem incentivado as pesquisas em plantas medicinais com atividade anti-Sporothrix spp. Um levantamento bibliográfico foi realizado com base em artigos científicos sobre a atividade antifúngica in vitro e in vivo de óleos essenciais e extratos de plantas preparados em diferentes solventes contra o complexo Sporothrix schenckii. A metodologia do estudo consistiu em uma revisão bibliográfica em Google Scholar, Science Direct, Pubmed, Bireme e Springer link com artigos desde 1986 até 2015. Foram encontradas 141 espécies de plantas já investigadas, das quais 100 espécies concentradas em 39 famílias botânicas apresentaram atividade anti-Sporothrix spp. confirmada. Combretaceae, Asteraceae e Lamiaceae representaram as famílias botânicas com maior número de espécies vegetais com potencial antifúngico, empregando diferentes metodologias. Entretanto, há poucos estudos com plantas medicinais em infecção experimental animal comprovando sua atividade no tratamento da esporotricose. Reforça-se a necessidade de mais pesquisas relacionadas à padronização de metodologias in vitro e a estudos in vivo relacionados à segurança e potencial tóxico dessas plantas com atividade anti-Sporothrix spp.Unitermos: Sporothrix schenckii. Antifúngicos. Combretaceae/farmacognosia. Asteraceae/f...

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Section: Broth Microdilution Methodsmentioning

confidence: 99%

Section: Broth Microdilution Methodsmentioning

confidence: 99%

Section: Broth Microdilution Methodsmentioning

confidence: 99%

Section: In Vitro Susceptibility Testsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Anti- Sporothrix spp. activity of medicinal plants

Waller

Madrid

Faria

et al. 2016

Braz. J. Pharm. Sci.

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Therapeutic benefits of rutin and its nanoformulations

Negahdari

Bohlouli

Sharifi

et al. 2020

Phytotherapy Research

122

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Background Rutin as a natural flavonoid compound has revealed an extensive range of therapeutic potentials. Purpose The current paper is focused on the numerous studies on rutin nanoformulations regarding its broad spectrum of therapeutic potentials. Study and methods A review was conducted in electronic databases (PubMed) to identify relevant published literature in English. No restrictions on publication date were imposed. Results The literature search provided 7,078 results for rutin. Among them, 25 papers were related to the potential biological activities of rutin nanoformulations. Polymeric nanoparticles were the most studied nanoformulations for rutin (14 titles) and lipid nanoparticles (5 titles) were in second place. The reviewed literature showed that rutin has been used as an antimicrobial, antifungal, and anti‐allergic agent. Improving the bioavailability of rutin using novel drug‐delivery methods will help the investigators to use its useful effects in the treatment of various chronic human diseases. Conclusion It can be concluded that the preparation of rutin nanomaterials for the various therapeutic objects confirmed the enhanced aqueous solubility as well as enhanced efficacy compared to conventional delivery of rutin. However, more investigations should be conducted to confirm the improved bioavailability of the rutin nanoformulations.

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Pharmacology of α‐spinasterol, a phytosterol with nutraceutical values: A review

Majeed¹,

Ahmad

Mundkur³

et al. 2022

Phytotherapy Research

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α‐Spinasterol is a phytosterol found in various edible and non‐edible plant sources. The edible plant materials containing α‐spinasterol include spinach leaves, cucumber fruits, seeds of pumpkin and watermelon, argan seed oil, cactus pear seed oil and Amaranthus sp. It is a bioavailable nutraceutical, and it can cross the blood–brain barrier. It possesses several important pharmacological properties such as anti‐diabetes mellitus, antiinflammation, hypolipidemic, antiulcer, neuroprotection, anti‐pain and antitumour activities. For this review, literature search was made focusing on the pharmacological properties of α‐spinasterol using PubMed and Google Scholar data bases. Recent studies show the promising antidiabetic properties of α‐spinasterol. Its anti‐diabetic mechanisms include enhancement of insulin secretion, reduction in insulin resistance, anti‐diabetic nephropathy, increase in glucose uptake in muscle cells and inhibition of glucose absorption from intestine. Besides, it is a safe antiinflammatory agent, and its antiinflammatory mechanisms include inhibition of cyclooxygenases, antagonism of TRPV1 receptor and attenuation of proinflammatory cytokines and mediators. It is a promising and safe nutraceutical molecule for human health care. Food supplements, value‐added products and nutraceutical formulations can be developed with α‐spinasterol for the management of diabetes, chronic inflammatory diseases and improving general health. This review provides all scattered pharmacological studies on α‐spinasterol in one place and highlights its immense value for human health care.

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Antifungal activity of five species of Polygala

Cited by 41 publications

References 14 publications

Anti- Sporothrix spp. activity of medicinal plants

Anti- Sporothrix spp. activity of medicinal plants

Therapeutic benefits of rutin and its nanoformulations

Pharmacology of α‐spinasterol, a phytosterol with nutraceutical values: A review

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