Antifungal activity of chalcones: A mechanistic study using various yeast strains

Lahtchev, Kantcho; Batovska, Daniela; Parushev, St.; Ubiyvovk, Vira M.; Sibirny, Andriy А.

doi:10.1016/j.ejmech.2007.12.027

Cited by 309 publications

(165 citation statements)

References 22 publications

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“…Chalcones have been recently the subject of great interest due to their interesting pharmacological activities, including antioxidant [1,2], antibacterial [3], antileishmanial [4], anticancer [5], antiangiogenic [6], anti-infective, anti-inflammatory [7], antifungal [8], anti-malarial [9], anti-tumor [10], anti-protozoal [11] and cytotoxic properties [12]. Many pyrazole derivatives are reported to have a broad spectrum of biological activities, such as anti-inflammatory [13], antifungal [14], antiviral [15], cytotoxic [12], A3 adenosine receptor antagonists [16], antioxidant [13], antihypertensive [17], tranquilizing, muscle relaxant, psychoanaleptic, hypnotic, ulcerogenic, antidepressant, antibacterial and analgesic effects [18].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Antibacterial and Antifungal Activity of Some New Pyrazoline and Pyrazole Derivatives

Hassan

2013

Molecules

136

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A series of 2-pyrazolines 5-9 have been synthesized from α,β-unsaturated ketones 2-4. New 2-pyrazoline derivatives 13-15 bearing benzenesulfonamide moieties were then synthesized by condensing the appropriate chalcones 2-4 with 4-hydrazinyl benzenesulfonamide hydrochloride. Ethyl [1,2,4] Condensation of 6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carbaldehyde (1') with compound 24 or 25 afforded the corresponding Schiff's bases 36 and 37, respectively. Reaction of the Schiff's base 37 with benzoyl hydrazine or acetic anhydride afforded benzohydrazide derivative 39 and the cyclized compound 40, respectively. Furthermore, the pyrazole derivatives 42-44 were synthesized by cyclization of hydrazine derivative 25 with the prepared chalcones 2-4. All the newly synthesized compounds have been characterized on the basis of IR and 1 H-NMR spectral data as well as physical data.Antimicrobial activity against the organisms E. coli ATCC8739 and P. aeruginosa ATCC 9027 as examples of Gram-negative bacteria, S. aureus ATCC 6583P as an example of Gram-positive bacteria and C. albicans ATCC 2091 as an example of a yeast-like fungus have been studied using the Nutrient Agar (NA) and Sabouraud Dextrose Agar (SDA) diffusion methods. The best performance was found for the compounds 16, 17, 19 and 20.

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Section: Introductionmentioning

confidence: 99%

Synthesis, Antibacterial and Antifungal Activity of Some New Pyrazoline and Pyrazole Derivatives

Hassan

2013

Molecules

136

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“…Chalcones possess a wide range of biological activities such as antibacterial 32 , antifungal 32 , antiviral 33 , antifeedant 3,29 , anticancer 34 , antimalarial 35 , antituberclosis 28 , antiAIDS 36 and antioxidant 37 activities. These multipronged activities present in different chalcones are examined against respective microbes-bacteria's and fungi.…”

Section: Microbial Activitiesmentioning

confidence: 99%

Preheated Fly-Ash Catalyzed Aldol Condensation: Efficient Synthesis of Chalcones and Antimicrobial Activities of Some 3-Thienyl Chalcones

Arulkumaran¹,

Vijayakumar²,

Sakthinathan³

et al. 2013

J. Chil. Chem. Soc.

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“…Chalcones and its derivatives have attracted increasing attention due to numerous pharmacological applications. They have displayed a broad spectrum of pharmacological activities, among which antimalarial [1][2][3][4] , antifungal 5,6 , antimicrobial 7 , larvicidal 8 , anticonvulsant 9 , antioxidant [10][11][12] activities. The IR spectrum supported the data showing the characteristic band for C=O at 1645 to 1655 and C=C at around 1570 to 1600 cm -1 and aromatic CH band between 3000 to 3100 cm -1 and aliphatic CH band stretching between 2900 to 3000 cm -1 and band for the C-S group is in the range of 600 to 800 cm -1 .…”

Section: Research Articlementioning

confidence: 99%

Comparative Study of Synthesis and Spectral Studies of Thiophenyl Carboxylate Derivatives by Microwave Irradiation and Conventional Method

2015

Chem Sci Trans

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A simple and novel synthesis of series carboxylates derivatives were synthesized by reacting different substituted thiophene-2yl-1-arylprop-3-ene-1-one (chalcones) with ethylacetoacetate in the presence of acid medium. The synthesis was carried out by conventional methods. The synthesized compounds have been monitored by TLC and characterized by elemental analysis, IR, 1 H NMR, 13 C NMR spectroscopy. The synthesised compounds were checked by their drug ability. The drug ability of the compounds was confirmed by Lipinski's Rule (Rule 5).

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Antifungal activity of chalcones: A mechanistic study using various yeast strains

Cited by 309 publications

References 22 publications

Synthesis, Antibacterial and Antifungal Activity of Some New Pyrazoline and Pyrazole Derivatives

Synthesis, Antibacterial and Antifungal Activity of Some New Pyrazoline and Pyrazole Derivatives

Preheated Fly-Ash Catalyzed Aldol Condensation: Efficient Synthesis of Chalcones and Antimicrobial Activities of Some 3-Thienyl Chalcones

Comparative Study of Synthesis and Spectral Studies of Thiophenyl Carboxylate Derivatives by Microwave Irradiation and Conventional Method

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