Abstract:The antiarrhythmic drug amiodarone was recently demonstrated to have novel broad range fungicidal activity. We provide evidence that amiodarone toxicity is mediated by disruption of Ca 2؉ homeostasis in Saccharomyces cerevisiae. In mutants lacking calcineurin and various Ca 2؉ transporters, including pumps (Pmr1 and Pmc1), channels (Cch1/Mid1 and Yvc1), and exchangers (Vcx1), amiodarone sensitivity correlates with cytoplasmic calcium overload. Measurements of cytosolic Ca
2؉by aequorin luminescence demonstrate… Show more
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