Antifungal activity in vitro of some imidazo[1,2-a]pyrimidine derivatives

A rapid and efficient method for synthesis of pyrimido[1,2‐a]‐benzimidazole derivatives under microwave irradiation

“…Imidazo [1,2-a]pyrimidine structural moieties are important as benzodiazepine receptor agonists [2], antiviral agents [3], antibacterials [4], antifungal agents [5], and calcium channel blockers [6]. Significant effort has been devoted to new synthetic methods and chemical reactivities regarding these ring systems [7,8].…”

Tin(II) Chloride Dihydrate Catalyzed Groebke Condensation: An Efficient Protocol for the Synthesis of 3‐Aminoimidazo[1,2‐a]pyridines

“…Organic compounds containing the imidazo[1,2-a]-pyridine ring system have been shown to possess a broad range of useful pharmacological activities, including antibacterial, 1 antifungal, 2 anthelmintic, 3 antiviral, 4 antiprotozoal, 5 anti-inflammatory, 6 anticonvulsant, 7 anxiolytic (Alpidem), hypnotic (Zolpidem), 8 antiulcer (Zolmidine), 7 and immunomodulatory (Kifunensine) activities. 9 They have also been shown to be selective cyclin dependant kinase inhibitors, 10 GABA and benzodiazepine receptor antagonists, 11 and bradykinin B 2 receptor antagonists.…”

A Facile Construction of 6‐(Arylmethyl)imidazo[1,2‐a]pyrimidin‐7‐ylamines from Allylamines Derived from Baylis–Hillman Adducts

“…[1] From the broad spectrum of pyrimidine-annulated heterocycles, imidazo[1,2-a]pyrimidine has been an attractive target for synthetic chemists, because compounds related to this scaffold are ligands for GABA A receptors, [2] benzodiazepine receptor agonists, [3] COX-2 inhibitors [4] and anticancer, [5] antimicrobial, [6] antibacterial [7] and antifungal [8] agents. Imidazo[1,2-a]pyrimidine also forms the core unit of the drug Divaplon ( Figure 1).…”