Antifeedant activity and high mortality in the pea aphid Acyrthosiphon pisum (Hemiptera: Aphidae) induced by biostable insect kinin analogs

Smagghe, Guy; Mahdian, Kamran; Zubrzak, Paweł; Nachman, Ronald J.

doi:10.1016/j.peptides.2009.07.001

Cited by 58 publications

(60 citation statements)

References 47 publications

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“…In addition, these analogous compounds also seemed to have aphicidal properties, although their mode of action could so far not be demonstrated (Smagghe et al 2010). In agreement with anti-feedant activities upon kinin analog administration in aphids, fruit flies mutant in either kinin or the kinin receptor consume larger meals, although at lower frequency than wild type flies.…”

Section: Insect Kininsmentioning

confidence: 95%

“…A detailed localization study in R. prolixus showed kinin-like immunostaining in neurons innervating the hindgut and lower posterior midgut, as well as in endocrine midgut cells (Te Brugge et al 2001). Although only one kinin has been identified in D. melanogaster (Terhzaz et al 1999;Vanden Broeck 2001), B. mori (Roller et al 2008), L. migratoria (Schoofs et al 1992) and A. pisum (Smagghe et al 2010), other species, such as L. maderae, A. aegypti, the house cricket (Acheta domesticus L., 1758), the mosquito Culex salinarius Coquillett, 1904, H. zea, P. americana (reviewed by Torfs et al 1999), and R. prolixus (Te Brugge et al 2011b), appear to contain multiple isoforms of this peptide. These different isoforms appear to be encoded by one precursor (Veenstra et al 1997;Te Brugge et al 2011b).…”

Section: Insect Kininsmentioning

confidence: 99%

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Peptidergic control of food intake and digestion in insects¹This review is part of a virtual symposium on recent advances in understanding a variety of complex regulatory processes in insect physiology and endocrinology, including development, metabolism, cold hardiness, food intake and digestion, and diuresis, through the use of omics technologies in the postgenomic era.

et al. 2012

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Like all heterotrophic organisms, insects require a strict control of food intake and efficient digestion of food into nutrients to maintain homeostasis and to fulfill physiological tasks. Feeding and digestion are steered by both external and internal signals that are transduced by a multitude of regulatory factors, delivered either by neurons innervating the gut or mouthparts, or by midgut endocrine cells. The present review gives an overview of peptide regulators known to control feeding and digestion in insects. We describe the discovery and functional role in these processes for insect allatoregulatory peptides, diuretic hormones, FMRFamide-related peptides, (short) neuropeptide F, proctolin, saliva production stimulating peptides, kinins, and tachykinins. These peptides control either gut myoactivity, food intake, and (or) release of digestive enzymes. Some peptides exert their action at multiple levels, possibly having a biological function that depends on their site of delivery. Many regulatory peptides have been physically extracted from different insect species. However, multiple peptidomics, proteomics, transcriptomics, and genome sequencing projects have led to increased discovery and prediction of peptide (precursor) and receptor sequences. In combination with physiological experiments, these large-scale projects have already led to important steps forward in unraveling the physiology of feeding and digestion in insects.Key words: insect, midgut, digestion, neuropeptides, stomatogastric nervous system. Résumé : Comme tous les organismes hétérotrophes, les insectes requièrent un contrôle strict de leur ingestion de nourriture et la digestion de leur nourriture en nutriments afin de maintenir leur homéostasie et de compléter leurs tâches physiologiques. L'alimentation et la digestion sont gouvernées par des signaux tant externes qu'internes qui sont transmis par un multitude de facteurs régulateurs, livrés ou bien par les neurones qui innervent le tube digestif ou les pièces buccales ou alors par les cellules endocrines du tube digestif moyen. Notre revue fournit une synthèse des régulateurs peptidiques connus pour contrôler l'alimentation et la digestion chez les insectes. Nous décrivons la découverte et le rôle fonctionnel de ces processus dans le cas des peptides allatorégulateurs, des hormones diurétiques, des peptides apparentés aux amides FMRF, du neuropeptide F (court), de la proctoline, des peptides stimulateurs de la production de salive, des kinines et des tachykinines des insectes. Ces peptides contrôlent la myoactivité du tube digestif, l'ingestion de nourriture et(ou) la libération des enzymes digestives. Certains peptides agissent à de multiples niveaux, possédant une fonction biologique qui dépend de leur site d'action. Plusieurs peptides régulateurs ont été extraits physiquement de différentes espèces d'insectes. Cependant, plusieurs projets de peptidomique, de protéomique, de transcriptomique et de génomique ont mené à de nombreuses découvertes supplémentaires et des prédict...

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Section: Insect Kininsmentioning

confidence: 95%

Section: Insect Kininsmentioning

confidence: 99%

Peptidergic control of food intake and digestion in insects¹This review is part of a virtual symposium on recent advances in understanding a variety of complex regulatory processes in insect physiology and endocrinology, including development, metabolism, cold hardiness, food intake and digestion, and diuresis, through the use of omics technologies in the postgenomic era.

et al. 2012

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“…Pymetrozine choicely prevent feeding in aphids which therefore causes starvation (Fluckiger et al, 1992, Kayser et al, 1994. Pymetrozine is presently utilized in aphids IPM program in agricultural crops (Smagghe et al, 2010). The present study aimed to assay the efficacy of biorational insecticides including insecticidal soap, surfactant and antifeeding for using in cucumber greenhouse plantings in connection with their potential to control A. gossypii.…”

Section: Introductionmentioning

confidence: 99%

Bioefficacy of some biorational insecticides for the control of Aphis gossypii Glover, 1877, (Hemiptera: Aphididae) on greenhouse grown cucumber

Emami

2016

AAS

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Aphis gossypii Glover, 1877 is a serious pest of cucumber in greenhouse plantings. Biorational insecticides are an alternative of broad spectrum insecticides for aphid suppression in greenhouse. In this regards, the efficiency of some biorational insecticides including soap based on coconut oil, surfactant based on sodium sulfosuccinate and antifeeding based on potassium nicotinate were assayed on A. gossypii in the cucumber greenhouse. The trials were set up in a randomized complete block design with four replications. Samplings were carried out one day before spraying and 3, 7, 14 and 21 days after spraying. The data were submitted to ANOVA and the means comparison was performed using Duncan’s test. The results indicated that the highest mortality in insecticidal soap, surfactant and antifeeding treatments occurred after 3 days, with 78.47 %, 67.16 % and 60.48 % mortality, respectively. The results of the trials are discussed in terms of improving management of the populations of A. gossypii.

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“…One biostable kinin peptidomimetic containing aminoisobutyric acid, 1728, has potency similar to or higher than the aedeskinins on recombinant receptors (12). Such biostable kinin analogs have potential in the control of insect pests because they reduce feeding in lepidopteran larvae (10,13) and increase aphid mortality (14,15).…”

mentioning

confidence: 99%

Leucokinin mimetic elicits aversive behavior in mosquito Aedes aegypti (L.) and inhibits the sugar taste neuron

Kwon

Agha

Smith

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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Insect kinins (leucokinins) are multifunctional peptides acting as neurohormones and neurotransmitters. In females of the mosquito vector Aedes aegypti (L.), aedeskinins are known to stimulate fluid secretion from the renal organs (Malpighian tubules) and hindgut contractions by activating a G protein-coupled kinin receptor designated "Aedae-KR." We used protease-resistant kinin analogs 1728, 1729, and 1460 to evaluate their effects on sucrose perception and feeding behavior. In no-choice feeding bioassays (capillary feeder and plate assays), the analog 1728, which contains α-amino isobutyric acid, inhibited females from feeding on sucrose. It further induced quick fly-away or walk-away behavior following contact with the tarsi and the mouthparts. Electrophysiological recordings from single long labellar sensilla of the proboscis demonstrated that mixing the analog 1728 at 1 mM with sucrose almost completely inhibited the detection of sucrose. Aedae-KR was immunolocalized in contact chemosensory neurons in prothoracic tarsi and in sensory neurons and accessory cells of long labellar sensilla in the distal labellum. Silencing Aedae-KR by RNAi significantly reduced gene expression and eliminated the feeding-aversion behavior resulting from contact with the analog 1728, thus directly implicating the Aedae-KR in the aversion response. To our knowledge, this is the first report that kinin analogs modulate sucrose perception in any insect. The aversion to feeding elicited by analog 1728 suggests that synthetic molecules targeting the mosquito Aedae-KR in the labellum and tarsi should be investigated for the potential to discover novel feeding deterrents of mosquito vectors.neuropeptide GPCR | sucrose taste | sensory neuron | chemical target validation | feeding deterrent

show abstract

Antifeedant activity and high mortality in the pea aphid Acyrthosiphon pisum (Hemiptera: Aphidae) induced by biostable insect kinin analogs

Cited by 58 publications

References 47 publications

Bioefficacy of some biorational insecticides for the control of Aphis gossypii Glover, 1877, (Hemiptera: Aphididae) on greenhouse grown cucumber

Leucokinin mimetic elicits aversive behavior in mosquito Aedes aegypti (L.) and inhibits the sugar taste neuron

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