Antidotes for acute cardenolide (cardiac glycoside) poisoning

A Novel Cardenolide Glycoside Isolated from Xysmalobium undulatum Reduces Levels of the Alzheimer’s Disease-Associated β-Amyloid Peptides Aβ42 In Vitro

“…However, of concern regarding cardenolides is their well-described cardiac toxicity [ 18 ]. This potentially could retard their development into clinically approved drugs.…”

A Novel Cardenolide Glycoside Isolated from Xysmalobium undulatum Reduces Levels of the Alzheimer’s Disease-Associated β-Amyloid Peptides Aβ42 In Vitro

“…However, of concern regarding cardenolides is their well-described cardiac toxicity [ 18 ]. This potentially could retard their development into clinically approved drugs.…”

A Novel Phytochemical, Digoxigenin‐3‐O‐Rutin in the Amelioration of Isoproterenol‐Induced Myocardial Infarction in Rat: A Comparison with Digoxin

“…TDR was also found to be more antiperoxidative than that of DIG as %inhibition in LPO and %increase in the status of antioxidants were more pronounced in the former group. Because of the fact that most of the cardiac glycosides available so far are known to be cardio-toxic [39,40], the presently isolated compound appears to be a novel cardenolide that is protective to heart as well as safe. This may be emphasized that earlier another active component of TFG seeds, 4-hydroxyisoleucine, was reported to regulate the hyperlipidemia [9].…”

Poisonous plants

“…Although expensive, such intervention might be warranted in animal intoxications depending on its economic value or the emotional attachment of the owner. Other potential antidotes such as atropine, isoproterenol, fructose-1,6-diphosphate, sodium bicarbonate, magnesium and phenytoin do not appear to be efficacious [50].…”

A Novel Cardenolide Glycoside Isolated from Xysmalobium undulatum Reduces Levels of the Alzheimer’s Disease-Associated β-Amyloid Peptides Aβ42 In Vitro

“…However, of concern regarding cardenolides is their well-described cardiac toxicity [ 18 ]. This potentially could retard their development into clinically approved drugs.…”

A Novel Phytochemical, Digoxigenin‐3‐O‐Rutin in the Amelioration of Isoproterenol‐Induced Myocardial Infarction in Rat: A Comparison with Digoxin

“…TDR was also found to be more antiperoxidative than that of DIG as %inhibition in LPO and %increase in the status of antioxidants were more pronounced in the former group. Because of the fact that most of the cardiac glycosides available so far are known to be cardio-toxic [39,40], the presently isolated compound appears to be a novel cardenolide that is protective to heart as well as safe. This may be emphasized that earlier another active component of TFG seeds, 4-hydroxyisoleucine, was reported to regulate the hyperlipidemia [9].…”

Poisonous plants

“…Although expensive, such intervention might be warranted in animal intoxications depending on its economic value or the emotional attachment of the owner. Other potential antidotes such as atropine, isoproterenol, fructose-1,6-diphosphate, sodium bicarbonate, magnesium and phenytoin do not appear to be efficacious [50].…”

A Novel Cardenolide Glycoside Isolated from Xysmalobium undulatum Reduces Levels of the Alzheimer’s Disease-Associated β-Amyloid Peptides Aβ42 In Vitro

“…However, of concern regarding cardenolides is their well-described cardiac toxicity [ 18 ]. This potentially could retard their development into clinically approved drugs.…”

A Novel Phytochemical, Digoxigenin‐3‐O‐Rutin in the Amelioration of Isoproterenol‐Induced Myocardial Infarction in Rat: A Comparison with Digoxin

“…TDR was also found to be more antiperoxidative than that of DIG as %inhibition in LPO and %increase in the status of antioxidants were more pronounced in the former group. Because of the fact that most of the cardiac glycosides available so far are known to be cardio-toxic [39,40], the presently isolated compound appears to be a novel cardenolide that is protective to heart as well as safe. This may be emphasized that earlier another active component of TFG seeds, 4-hydroxyisoleucine, was reported to regulate the hyperlipidemia [9].…”

Poisonous plants

“…Although expensive, such intervention might be warranted in animal intoxications depending on its economic value or the emotional attachment of the owner. Other potential antidotes such as atropine, isoproterenol, fructose-1,6-diphosphate, sodium bicarbonate, magnesium and phenytoin do not appear to be efficacious [50].…”