Antidiuretic Hormone Response in Children With Bronchopulmonary Dysplasia During Episodes of Acute Respiratory Distress

Plasma copeptin is increased and associated with smaller kidney volume in young adults born very preterm

“…In our study, we also demonstrated that a more severe neonatal course, as shown by a history of moderate–severe BPD, was associated with a further increase in plasma copeptin levels in early adulthood and with higher ACR than in those born preterm with a less severe neonatal course. These results are in line with several reports that had previously associated increased AVP levels with BPD in neonates [ 21–23 ]. These results are suggestive of long-term dysregulation of AVP levels following very preterm birth, especially in cases of severe neonatal disease, with potentially adverse consequences on kidney function.…”

Dexamethasone does not affect vasopressin release in bronchopulmonary dysplasia

“…As a consequence, the concurrent improvement in lung function, and the reduction in weight gain observed in the present study, is not generated via a change in endogenous vasopressin concentration, and potentially induced by steroid treatment (as observed in animal and adult human studies). These data extend previous observations of Rao et al [1], Hazinski et al [2], and Kojima et al [3], who suggested that critically ill infants in the early or later stages of BPD, and presenting with elevated levels of AVP, may not be in a steady state of water balance.…”

Control of Water Balance in Infants with Bronchopulmonary Dysplasia: Role of Endogenous Vasopressin

“…Moreover, although the number of ventilated infants is small, these high levels cannot be explained by the presence of positive airway pressures, or by mechanical ventilation; these factors may increase vasopressin secretion in newborn infants (1 3-16). These data extend the observations of Rao et al (17) who found elevated vasopressin levels in 12 infants with BPD who were rehospitalized for acute severe respiratory failure. In their study, hyponatremia was rare despite high vasopressin levels, suggesting that these acutely sick infants may have been in a nonsteady state in terms of their water balance.…”